Patents by Inventor Adam De La Zerda
Adam De La Zerda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230384609Abstract: A diffractive optical element includes a substrate including a plurality of unit cells arrayed across the substrate. Each of the unit cells includes M phase elements and each of the M phase elements is characterized by one of a set of N phase values. Each of the set of N phase values is equal to an incremental phase value times an index m, wherein M>1 and m=1 . . . N.Type: ApplicationFiled: August 9, 2023Publication date: November 30, 2023Inventors: Jingjing Zhao, Adam de la Zerda
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Patent number: 11529633Abstract: An apparatus includes a substrate, a first heating element, and a second heating element. The substrate includes a first portion, a second portion, and a third portion that is between the first portion and the second portion. The first portion is characterized by a first thermal conductivity, the second portion is characterized by a second thermal conductivity, and the third portion is characterized by a third thermal conductivity. The third thermal conductivity is less than the first thermal conductivity and the second thermal conductivity. The first heating element is coupled to the first portion of the substrate, and is configured to produce a first thermal output. The second heating element is coupled to the second portion of the substrate, and configured to produce a second thermal output. The second thermal output is different from the first thermal output.Type: GrantFiled: May 25, 2021Date of Patent: December 20, 2022Assignee: Visby Medical, Inc.Inventors: Boris Andreyev, Brian Ciopyk, Victor Briones, Jonathan Hong, David Swenson, Gregory Loney, Adam De La Zerda, Steven Chu
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Publication number: 20220198689Abstract: Alignment of a 2D image to a corresponding 3D image is provided by writing a pattern into a 3D sample. The pattern is at known positions in the 3D image, and provides visible reference features in the 2D image. This permits accurate determination of the plane in the 3D image that corresponds to the 2D image.Type: ApplicationFiled: April 10, 2020Publication date: June 23, 2022Inventors: Yonatan Winetraub, Edwin Yuan, Itamar Terem, Caroline Yu, Adam de la Zerda
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Publication number: 20220186208Abstract: Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).Type: ApplicationFiled: October 22, 2021Publication date: June 16, 2022Inventors: David D. SWENSON, Gregory C. LONEY, Valeria REVILLA, Adrienne C. LAM, Helen HUANG, Colin KELLY, Victor BRIONES, Brian CIOPYK, Boris ANDREYEV, Adam DE LA ZERDA, Keith MORAVICK, Jesus CHING, Jennifer ALBRECHT, Ryan CENA, Edward BIBA, Jonathan HONG
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Patent number: 11273443Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: GrantFiled: October 14, 2020Date of Patent: March 15, 2022Assignee: Visby Medical, Inc.Inventors: Boris Andreyev, Keith E. Moravick, Brian Ciopyk, Victor Briones, Gregory Loney, Adam De La Zerda, Jesus Ching, Steven Chu, David Swenson, Helen Huang, Colin Kelly
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Publication number: 20220055032Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: ApplicationFiled: October 22, 2021Publication date: February 24, 2022Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
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Publication number: 20220042076Abstract: A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.Type: ApplicationFiled: October 22, 2021Publication date: February 10, 2022Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Victor BRIONES, Ryan T. CENA, Adam DE LA ZERDA, Colin KELLY, Gregory LONEY, Gary SCHOOLNIK, David SWENSON
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Patent number: 11193119Abstract: Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).Type: GrantFiled: November 9, 2018Date of Patent: December 7, 2021Assignee: Visby Medical, Inc.Inventors: David D. Swenson, Gregory C. Loney, Valeria Revilla, Adrienne C. Lam, Helen Huang, Colin Kelly, Victor Briones, Brian Ciopyk, Boris Andreyev, Adam De La Zerda, Keith Moravick, Jesus Ching, Jennifer Albrecht, Ryan Cena, Edward Biba, Jonathan Hong
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Publication number: 20210354132Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: ApplicationFiled: October 14, 2020Publication date: November 18, 2021Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
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Publication number: 20210354131Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: ApplicationFiled: September 11, 2020Publication date: November 18, 2021Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
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Patent number: 11168354Abstract: A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.Type: GrantFiled: November 9, 2020Date of Patent: November 9, 2021Assignee: Visby Medical, Inc.Inventors: Boris Andreyev, Victor Briones, Ryan T. Cena, Adam De La Zerda, Colin Kelly, Gregory Loney, Gary Schoolnik, David Swenson
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Patent number: 11167285Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: GrantFiled: August 23, 2018Date of Patent: November 9, 2021Assignee: Visby Medical, Inc.Inventors: Boris Andreyev, Keith E. Moravick, Brian Ciopyk, Victor Briones, Gregory Loney, Adam De La Zerda, Jesus Ching, Steven Chu, David Swenson, Helen Huang, Colin Kelly
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Patent number: 11162130Abstract: A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.Type: GrantFiled: November 9, 2018Date of Patent: November 2, 2021Assignee: Visby Medical, Inc.Inventors: Boris Andreyev, Victor Briones, Ryan T. Cena, Adam De La Zerda, Colin Kelly, Gregory Loney, Gary Schoolnik, David Swenson
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Publication number: 20210331159Abstract: A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.Type: ApplicationFiled: August 23, 2018Publication date: October 28, 2021Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Keith E. MORAVICK, Brian CIOPYK, Victor BRIONES, Gregory LONEY, Adam DE LA ZERDA, Jesus CHING, Steven CHU, David SWENSON, Helen HUANG, Colin KELLY
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Publication number: 20210283616Abstract: An apparatus includes a substrate, a first heating element, and a second heating element. The substrate includes a first portion, a second portion, and a third portion that is between the first portion and the second portion. The first portion is characterized by a first thermal conductivity, the second portion is characterized by a second thermal conductivity, and the third portion is characterized by a third thermal conductivity. The third thermal conductivity is less than the first thermal conductivity and the second thermal conductivity. The first heating element is coupled to the first portion of the substrate, and is configured to produce a first thermal output. The second heating element is coupled to the second portion of the substrate, and configured to produce a second thermal output. The second thermal output is different from the first thermal output.Type: ApplicationFiled: May 25, 2021Publication date: September 16, 2021Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Brian CIOPYK, Victor BRIONES, Jonathan HONG, David SWENSON, Gregory LONEY, Adam DE LA ZERDA, Steven CHU
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Publication number: 20210237090Abstract: An apparatus includes a substrate, a first heating element, and a second heating element. The substrate includes a first portion, a second portion, and a third portion that is between the first portion and the second portion. The first portion is characterized by a first thermal conductivity, the second portion is characterized by a second thermal conductivity, and the third portion is characterized by a third thermal conductivity. The third thermal conductivity is less than the first thermal conductivity and the second thermal conductivity. The first heating element is coupled to the first portion of the substrate, and is configured to produce a first thermal output. The second heating element is coupled to the second portion of the substrate, and configured to produce a second thermal output. The second thermal output is different from the first thermal output.Type: ApplicationFiled: April 19, 2021Publication date: August 5, 2021Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Brian CIOPYK, Victor BRIONES, Jonathan HONG, David SWENSON, Gregory LONEY, Adam DE LA ZERDA, Steven CHU
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Patent number: 10987674Abstract: An apparatus includes a substrate, a first heating element, and a second heating element. The substrate includes a first portion, a second portion, and a third portion that is between the first portion and the second portion. The first portion is characterized by a first thermal conductivity, the second portion is characterized by a second thermal conductivity, and the third portion is characterized by a third thermal conductivity. The third thermal conductivity is less than the first thermal conductivity and the second thermal conductivity. The first heating element is coupled to the first portion of the substrate, and is configured to produce a first thermal output. The second heating element is coupled to the second portion of the substrate, and configured to produce a second thermal output. The second thermal output is different from the first thermal output.Type: GrantFiled: April 21, 2017Date of Patent: April 27, 2021Assignee: Visby Medical, Inc.Inventors: Boris Andreyev, Brian Ciopyk, Victor Briones, Jonathan Hong, David Swenson, Gregory Loney, Adam De La Zerda, Steven Chu
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Patent number: 10960399Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.Type: GrantFiled: December 20, 2018Date of Patent: March 30, 2021Assignee: Visby Medical, Inc.Inventors: Hamilton R. Tang, Adam De La Zerda, Kenneth I. Li, Kevin M. Limtao, Alan D. Baldwin, Gregory C. Loney
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Publication number: 20210069718Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.Type: ApplicationFiled: October 30, 2020Publication date: March 11, 2021Applicant: Visby Medical, Inc.Inventors: Hamilton R. TANG, Adam DE LA ZERDA, Kenneth I. LI, Kevin M. LIMTAO, Alan D. BALDWIN, Gregory C. LONEY
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Publication number: 20210071236Abstract: A method includes coupling a molecular diagnostic test device to a power source. A biological sample is conveyed into a sample preparation module. The device is then actuated by only a single action to cause the device to perform the following functions without further user action. First, the device heats the sample via a heater of the sample preparation module to lyse a portion of the sample. Second, the device conveys the lysed sample to an amplification module and heats the sample within a reaction volume of the amplification module to amplify a nucleic acid thereby producing an output solution containing a target amplicon. The device then reacts, within a detection module, each of (i) the output solution and (ii) a reagent formulated to produce a signal that indicates a presence of the target amplicon within the output solution. A result associated with the signal is then read.Type: ApplicationFiled: November 9, 2020Publication date: March 11, 2021Applicant: Visby Medical, Inc.Inventors: Boris ANDREYEV, Victor BRIONES, Ryan T. CENA, Adam DE LA ZERDA, Colin KELLY, Gregory LONEY, Gary SCHOOLNIK, David SWENSON