Patents by Inventor Adam Dempsey
Adam Dempsey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11236711Abstract: A combustion system for an internal combustion engine includes a cylinder wall; a cylinder head disposed at an end of the cylinder wall, an internal surface of the cylinder wall and the cylinder head defining a combustion chamber; a fuel injector having a discharge nozzle disposed within the combustion chamber and configured to discharge a fuel jet along a fuel jet axis; and a bluff body disposed within the combustion chamber, the fuel jet axis intersecting an exterior surface of the bluff body. The exterior surface defines a first aperture and a second aperture therethrough, and an interior surface of the bluff body defines a first flow passage extending from the first aperture to the second aperture. The first aperture faces away from the fuel jet axis and the second aperture faces away from the fuel injector along the fuel jet axis.Type: GrantFiled: September 13, 2020Date of Patent: February 1, 2022Assignee: Caterpillar Inc.Inventors: Adam Dempsey, Kenth I. Svensson
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Publication number: 20200408175Abstract: A combustion system for an internal combustion engine includes a cylinder wall; a cylinder head disposed at an end of the cylinder wall, an internal surface of the cylinder wall and the cylinder head defining a combustion chamber; a fuel injector having a discharge nozzle disposed within the combustion chamber and configured to discharge a fuel jet along a fuel jet axis; and a bluff body disposed within the combustion chamber, the fuel jet axis intersecting an exterior surface of the bluff body. The exterior surface defines a first aperture and a second aperture therethrough, and an interior surface of the bluff body defines a first flow passage extending from the first aperture to the second aperture. The first aperture faces away from the fuel jet axis and the second aperture faces away from the fuel injector along the fuel jet axis.Type: ApplicationFiled: September 13, 2020Publication date: December 31, 2020Applicant: Caterpillar Inc.Inventors: Adam Dempsey, Kenth I. Svensson
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Patent number: 10876464Abstract: A piston for an internal combustion engine includes a crown portion having a bowl that includes a plurality of protrusions. Each of the plurality of protrusions includes a first side surface and a second side surface. Other features including at least one ledge formed between protrusions in segments, and a generally flat, inward facing surface on the protrusions may also be used.Type: GrantFiled: September 25, 2018Date of Patent: December 29, 2020Assignee: Caterpillar Inc.Inventors: Kenth I. Svensson, Jonathan W. Anders, Adam Dempsey
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Publication number: 20200095920Abstract: A piston for an internal combustion engine includes a crown portion having a bowl that includes a plurality of protrusions. Each of the plurality of protrusions includes a first side surface and a second side surface. Other features including at least one ledge formed between protrusions in segments, and a generally flat, inward facing surface on the protrusions may also be used.Type: ApplicationFiled: September 25, 2018Publication date: March 26, 2020Applicant: Caterpillar Inc.Inventors: Kenth I. Svensson, Jonathan W. Anders, Adam Dempsey
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Publication number: 20190301408Abstract: A combustion system for an internal combustion engine includes combustion chamber that is defined between a cylinder head and a top surface of a piston. The combustion system also includes a fuel injector having an injector tip. The injector tip defines a nozzle disposed in fluid communication with the combustion chamber for dispensing a fuel jet into the combustion chamber. A bluff body is positioned within the combustion chamber such that an axis of the dispensed fuel jet is incident on an anterior portion of the bluff body proximal to the injector tip. The anterior portion has a contour that is adapted to split the dispensed fuel jet into at least two turbulent fuel streams and facilitate mixing of each fuel stream with an oxidant present in the combustion chamber.Type: ApplicationFiled: April 2, 2018Publication date: October 3, 2019Applicant: Caterpillar Inc.Inventors: Adam Dempsey, Kenth I. Svensson
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Publication number: 20140057258Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.Type: ApplicationFiled: July 8, 2013Publication date: February 27, 2014Applicant: GeneNews, CorporationInventors: Choong-Chin Liew, Hongwei Zhang, Adam Dempsey, Thomas Yager, Samuel Chao
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Patent number: 8483968Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.Type: GrantFiled: May 10, 2010Date of Patent: July 9, 2013Assignee: GeneNews CorporationInventors: Choong-Chin Liew, Hongwei Zhang, Adam Dempsey, Thomas Yager, Samuel Chao
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Publication number: 20130165336Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in blood and useful in diagnosing schizophrenia and/or bipolar disorder as well as monitoring therapeutic efficacy of treatment for schizophrenia or bipolar disorder. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention can be used to diagnose schizophrenia and/or bipolar disorder. Measurement of the expression level of products of biomarkers of the invention using polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are compositions and kits containing said polynucleotides and proteins. Further encompassed by the invention is the use of the polynucleotides and proteins to monitor the efficacy of therapeutic regimens.Type: ApplicationFiled: September 4, 2012Publication date: June 27, 2013Inventors: Choong-Chin Liew, Thomas Yager, Adam Dempsey, Samuel Chao
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Publication number: 20130017965Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of OA. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers are within the scope of the invention as are kits containing said polynucleotides and proteins and the use of said polynucleotides and proteins.Type: ApplicationFiled: January 18, 2012Publication date: January 17, 2013Applicant: GENENEWS, INC.Inventors: CHOONG-CHIN LIEW, THOMAS YAGER, ADAM DEMPSEY, SAMUEL CHAO, HONGWEI ZHANG, WAYNE MARSHALL
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Patent number: 8258284Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in blood and useful in diagnosing schizophrenia and/or bipolar disorder as well as monitoring therapeutic efficacy of treatment for schizophrenia or bipolar disorder. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention can be used to diagnose schizophrenia and/or bipolar disorder. Measurement of the expression level of products of biomarkers of the invention using polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are compositions and kits containing said polynucleotides and proteins. Further encompassed by the invention is the use of the polynucleotides and proteins to monitor the efficacy of therapeutic regimens.Type: GrantFiled: May 10, 2010Date of Patent: September 4, 2012Assignee: GeneNews, Inc.Inventors: Choong-Chin Liew, Thomas Yager, Adam Dempsey, Samuel Chao
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Patent number: 8142998Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of OA. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers are within the scope of the invention as are kits containing the polynucleotides and proteins and the use of the polynucleotides and proteins.Type: GrantFiled: September 4, 2009Date of Patent: March 27, 2012Assignee: GeneNews, Inc.Inventors: Choong-Chin Liew, Thomas Yager, Adam Dempsey, Samuel Chao, Hongwei Zhang, Wayne Marshall
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Patent number: 7991557Abstract: The present invention provides systems and method for constructing classifiers that distinguish between trait subgroups using molecular marker data from blood samples. The invention further encompasses the use of the classifiers and combinations of molecular markers identified by the classifiers in a wide variety of applications including: diagnosis; prognosis; prediction of disease, stage of disease or disease risk; monitoring disease progression and/or regression; monitoring disease reoccurrence and identifying risk of disease reoccurrence; determining and/or predicting response to treatment and/or treatment outcomes; monitoring and/or predicting treatment compliance or non compliance and the like. The invention further provides a variety of selected molecular markers and a means to identify combinations of the selected molecular markers useful for diagnosing particular traits of interest.Type: GrantFiled: June 20, 2005Date of Patent: August 2, 2011Assignee: Genenews CorporationInventors: Choong-Chin Liew, Thomas Yager, Adam Dempsey, Samuel Chao
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Publication number: 20110020808Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in blood and useful in diagnosing schizophrenia and/or bipolar disorder as well as monitoring therapeutic efficacy of treatment for schizophrenia or bipolar disorder. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention can be used to diagnose schizophrenia and/or bipolar disorder. Measurement of the expression level of products of biomarkers of the invention using polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are compositions and kits containing said polynucleotides and proteins. Further encompassed by the invention is the use of the polynucleotides and proteins to monitor the efficacy of therapeutic regimens.Type: ApplicationFiled: May 10, 2010Publication date: January 27, 2011Inventors: Choong-Chin Liew, Thomas Yager, Adam Dempsey, Samuel Chao
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Publication number: 20110020809Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.Type: ApplicationFiled: May 10, 2010Publication date: January 27, 2011Inventors: Choong-Chin Liew, Hongwei Zhang, Adam Dempsey, Thomas Yager, Samuel Chao
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Publication number: 20100143916Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in osteoarthritis and/or in a particular stage of osteoarthritis, as well as a means of selecting the novel biomarker combinations. The measurement of expression of the products of the biomarkers and combinations of biomarkers of the invention demonstrates particular advantage in one or more of the following: (a) diagnosing individuals as having arthritis, (b) differentiating between two stages of osteoarthritis (OA) and (c) diagnosing individuals as having a particular stage of osteoarthritis (OA).Type: ApplicationFiled: September 4, 2009Publication date: June 10, 2010Inventors: Choong-Chin Liew, Thomas Yager, Adam Dempsey, Samuel Chao, Hongwei Zhang, Wayne Marshall
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Patent number: 7713702Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in blood and useful in diagnosing schizophrenia and/or bipolar disorder as well as monitoring therapeutic efficacy of treatment for schizophrenia or bipolar disorder. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention can be used to diagnose schizophrenia and/or bipolar disorder. Measurement of the expression level of products of biomarkers of the invention using polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are compositions and kits containing said polynucleotides and proteins. Further encompassed by the invention is the use of the polynucleotides and proteins to monitor the efficacy of therapeutic regimens.Type: GrantFiled: October 10, 2008Date of Patent: May 11, 2010Assignee: GeneNews CorporationInventors: Choong-Chin Liew, Thomas Yager, Adam Dempsey, Samuel Chao
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Patent number: 7713695Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.Type: GrantFiled: February 6, 2006Date of Patent: May 11, 2010Assignee: GeneNews, Inc.Inventors: Choong-Chin Liew, Hongwei Zhang, Adam Dempsey, Thomas Yager, Samuel Chao
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Publication number: 20090098564Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in blood and useful in diagnosing schizophrenia and/or bipolar disorder as well as monitoring therapeutic efficacy of treatment for schizophrenia or bipolar disorder. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention can be used to diagnose schizophrenia and/or bipolar disorder. Measurement of the expression level of products of biomarkers of the invention using polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are compositions and kits containing said polynucleotides and proteins. Further encompassed by the invention is the use of the polynucleotides and proteins to monitor the efficacy of therapeutic regimens.Type: ApplicationFiled: October 10, 2008Publication date: April 16, 2009Inventors: Choong-Chin Liew, Thomas Yager, Adam Dempsey, Samuel Chao
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Publication number: 20070269804Abstract: The present invention provides systems and method for constructing classifiers that distinguish between trait subgroups using molecular marker data from blood samples. The invention further encompasses the use of the classifiers and combinations of molecular markers identified by the classifiers in a wide variety of applications including: diagnosis; prognosis; prediction of disease, stage of disease or disease risk; monitoring disease progression and/or regression; monitoring disease reoccurrence and identifying risk of disease reoccurrence; determining and/or predicting response to treatment and/or treatment outcomes; monitoring and/or predicting treatment compliance or non compliance and the like. The invention further provides a variety of selected molecular markers and a means to identify combinations of the selected molecular markers useful for diagnosing particular traits of interest.Type: ApplicationFiled: June 20, 2005Publication date: November 22, 2007Applicant: CHONDROGENE, INC.Inventors: Choong-Chin Liew, Thomas Yager, Adam Dempsey, Samuel Chao
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Publication number: 20060263797Abstract: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with mild osteoarthritis as compared with individuals without osteoarthritis. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers of the invention are also encompassed within the scope of the invention as are kits containing said polynucleotides and proteins for use in diagnosing mild osteoarthritis. Further encompassed by the invention is the use of the polynucleotides and proteins which specifically and/or selectively hybridize to the product of the biomarkers of the invention to monitor disease regression in an individual and to monitor the efficacy of therapeutic regimens. The invention also provides for methods of using the products of the biomarkers of the invention in the identification of novel therapeutic targets for osteoarthritis.Type: ApplicationFiled: February 6, 2006Publication date: November 23, 2006Inventors: Choong-Chin Liew, Hongwei Zhang, Adam Dempsey, Thomas Yager, Samuel Chao