Patents by Inventor Adam E. Cohen

Adam E. Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10828088
    Abstract: The inventive ablation element comprises an elongated cannula having a proximal end and a distal end. The cannula defines an internal lumen within the cannula and a cannula axis. A plurality of conductors contained within the lumen, each of the conductors has a proximal end proximate the proximal end of the cannula, and a distal end proximate the distal end of the cannula. A plurality of ablation stylets each has a proximal end and a distal end, and each coupled at the respective proximal end of the stylet to the distal end of a respective conductor, the stylets comprise a deflectable material, the conductors together with their respective stylets being mounted for axial movement. A trocar point defined proximate the distal end of the cannula.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: November 10, 2020
    Assignee: ACESSA HEALTH INC.
    Inventors: Bruce B. Lee, Gordon E. Epstein, Adam Hagmann, Jeffrey M. Cohen
  • Publication number: 20200088643
    Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
    Type: Application
    Filed: November 19, 2019
    Publication date: March 19, 2020
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyarfas, Jeremy Lackey, Gerard Schmid, Benjamin Cipriany, Jack Jewell, Lawrence C. West, Michael Ferrigno, Paul E. Glenn, Adam Ezra Cohen, Anthony Bellofiore
  • Patent number: 10533945
    Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: January 14, 2020
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyarfas, Jeremy Lackey, Gerard Schmid, Benjamin Cipriany, Jack Jewell, Lawrence C. West, Michael Ferrigno, Paul E. Glenn, Adam Ezra Cohen, Anthony Bellofiore
  • Patent number: 10479895
    Abstract: A surface can be coated with a liquid repellent coating. Materials for making the liquid repellent coating (e.g., a fingerprint resistant coating) can be selected on the basis of surface energy considerations, such as a receding surface energy. The materials can include a polymer and a liquid repelling material, for example, poly(ethyl methacrylate) and a fluorinated silsesquioxane such as fluorodecyl POSS.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: November 19, 2019
    Assignee: United States of America as represented by the Secretary of the Air Force
    Inventors: Adam J. Meuler, Robert E. Cohen, Gareth H. McKinley, Joseph M. Mabry
  • Patent number: 10457715
    Abstract: Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: October 29, 2019
    Assignees: President and Fellows of Harvard College, The Governors of the University of Alberta
    Inventors: Adam E. Cohen, Daniel Hochbaum, Peng Zou, Samouil Leon Farhi, Robert Earl Campbell, Yongxin Zhao, Daniel Jed Harrison
  • Patent number: 10392426
    Abstract: The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: August 27, 2019
    Assignees: Massachusetts Institute of Technology, The Governors of the University of Alberta, President and Fellows of Harvard College
    Inventors: Nathan Klapoetke, Edward Boyden, Yongku Cho, Brian Y. Chow, Gane K. S. Wong, Adam E. Cohen, Daniel R. Hochbaum
  • Patent number: 10294756
    Abstract: This invention relates generally to articles, devices, and methods for gas hydrate mitigation in deep-sea drilling applications. In certain embodiments, hydrate-phobic surfaces are provided that ensure passive enhancement of flow assurance and prevention of catastrophic failures in deep-sea oil and gas operations.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: May 21, 2019
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: J. David Smith, Kripa K. Varanasi, Gareth H. McKinley, Robert E. Cohen, Adam J. Meuler, Harrison L. Bralower
  • Patent number: 10077463
    Abstract: Provided herein are photochemical crosslinkers and photocleavable crosslinkers and their uses in methods for cell selection from cell cultures. The photochemical crosslinkers comprise a fluorescent dye and a radical generator. The photocleavable crosslinkers comprise a photocleavable linker linking two electrophilic groups to each other. Also provided are systems for imaging cells comprising a plurality of cells crosslinked to extracellular matrix proteins using a crosslinker as described, an imaging apparatus, an illuminating apparatus, and software for image processing.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: September 18, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Adam E. Cohen, Miao-Ping Chien
  • Patent number: 10048193
    Abstract: A curved surface is placed tangent to a slide and displaces a sample liquid from the point or line of contact outward. Imaging indicates a region where fluorescence is observed, and the location of the fluorescence indicates the molecular size. The radius of curvature of the lens is known, the distance from the (center) point of contact of the observed fluorescence is measured with a microscope and the distance of the lens surface to the slide's surface can then be calculated. This distance represents the size of the molecule or ensemble of molecules emitting. Similarly, absorbance, etc. could be measured with a light source below the slide.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: August 14, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Adam E. Cohen, Sabrina R. Leslie
  • Patent number: 9863880
    Abstract: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: January 9, 2018
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Ali Kabiri, Jason W. Sickler, Brett J. Gyarfas, Jeremy Lackey, Gerard Schmid, Benjamin Cipriany, Jack Jewell, Lawrence West, Michael Ferrigno, Paul E. Glenn, Adam E. Cohen, Anthony Bellofiore
  • Publication number: 20170313757
    Abstract: Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants.
    Type: Application
    Filed: November 28, 2016
    Publication date: November 2, 2017
    Applicants: President and Fellows of Harvard College, The Governors of the University of Alberta
    Inventors: Adam E. Cohen, Daniel Hochbaum, Peng Zou, Samouil Leon Farhi, Robert Earl Campbell, Yongxin Zhao, Daniel Jed Harrison
  • Patent number: 9791455
    Abstract: The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using electrodes. The methods can be directed to, for example, high-throughput drug screening assays to determine agents that can affect membrane potential of a target cell.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: October 17, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Adam E. Cohen, Joel Kralj, Adam D. Douglass
  • Patent number: 9702874
    Abstract: The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: July 11, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Adam E. Cohen, Joel Kralj, Adam D. Douglass, Daniel Hochbaum
  • Publication number: 20170174730
    Abstract: The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.
    Type: Application
    Filed: March 1, 2017
    Publication date: June 22, 2017
    Applicants: Massachusetts Institute of Technology, The Governors of the University of Alberta, President and Fellows of Harvard College
    Inventors: Nathan Klapoetke, Edward Boyden, Yongku Cho, Brian Y. Chow, Gane K.S. Wong, Adam E. Cohen, Daniel R. Hochbaum
  • Publication number: 20170160188
    Abstract: A curved surface is placed tangent to a slide and displaces a sample liquid from the point or line of contact outward. Imaging indicates a region where fluorescence is observed, and the location of the fluorescence indicates the molecular size, The radius of curvature of the lens is known, the distance from the (center) point of contact of the observed fluorescence is measured with a microscope and the distance of the lens surface to the slide's surface can then be calculated. This distance represents the size of the molecule or ensemble of molecules emitting. Similarly, absorbance, etc. could be measured with a light source below the slide.
    Type: Application
    Filed: August 11, 2016
    Publication date: June 8, 2017
    Inventors: Adam E. COHEN, Sabrina R. LESLIE
  • Patent number: 9518103
    Abstract: Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: December 13, 2016
    Assignees: President and Fellows of Harvard College, The Governors of the University of Alberta
    Inventors: Adam E. Cohen, Daniel Hochbaum, Peng Zou, Samouil Leon Farhi, Robert Earl Campbell, Yongxin Zhao, Daniel Jed Harrison
  • Publication number: 20160208308
    Abstract: Provided herein are photochemical crosslinkers and photocleavable crosslinkers and their uses in methods for cell selection from cell cultures. The photochemical crosslinkers comprise a fluorescent dye and a radical generator. The photocleavable crosslinkers comprise a photocleavable linker linking two electrophilic groups to each other. Also provided are systems for imaging cells comprising a plurality of cells crosslinked to extracellular matrix proteins using a crosslinker as described, an imaging apparatus, an illuminating apparatus, and software for image processing.
    Type: Application
    Filed: January 14, 2016
    Publication date: July 21, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Adam E. Cohen, Miao-Ping Chien
  • Publication number: 20160069876
    Abstract: The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.
    Type: Application
    Filed: November 16, 2015
    Publication date: March 10, 2016
    Applicant: President and Fellows of Harvard College
    Inventors: Adam E. Cohen, Joel Kralj, Adam D. Douglass, Daniel Hochbaum
  • Publication number: 20150369740
    Abstract: Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants.
    Type: Application
    Filed: June 17, 2015
    Publication date: December 24, 2015
    Applicants: President and Fellows of Harvard College, The Governors of the University of Alberta
    Inventors: Adam E. Cohen, Daniel Hochbaum, Peng Zou, Samouil Leon Farhi, Robert Earl Campbell, Yongxin Zhao, Daniel Jed Harrison
  • Patent number: 9207237
    Abstract: The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: December 8, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Adam E. Cohen, Joel Kralj, Adam D. Douglass, Daniel Hochbaum