Patents by Inventor Adam E. Osborne

Adam E. Osborne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of DNA damage and mitochondrial dysfunction using palm fruit juice
    Patent number: 10813972
    Abstract: Methods, compositions and kits for the prevention and treatment of mitochondrial dysfunction, mitochondrial DNA damage and genomic DNA damage are provided. The methods use the administration of palm fruit juice and/or compositions containing phenolic compounds present in palm fruit juice. The methods, compositions, and kits can be used to reduce DNA damage in subjects being treated with nucleoside reverse transcriptase inhibitors, such as patients having HIV or AIDS.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: October 27, 2020
    Assignees: MALAYSIAN PALM OIL BOARD, BRANDEIS UNIVERSITY
    Inventors: Adam E. Osborne, Lawrence J. Wangh, Kenneth C. Hayes, Ravigadevi Sambanthamurthi
  • MISPRIMING PREVENTION REAGENTS
    Publication number: 20200032310
    Abstract: Provided herein are mispriming prevention reagents, compositions and kits comprising such reagents and methods of use thereof.
    Type: Application
    Filed: March 25, 2019
    Publication date: January 30, 2020
    Inventors: Lawrence J. Wangh, Kenneth E. Pierce, Jesus A. Sanchez, John E. Rice, Alexandra I. King Over, Adam E. Osborne
  • Mispriming prevention reagents
    Patent number: 10240178
    Abstract: Provided herein are mispriming prevention reagents, compositions and kits comprising such reagents and methods of use thereof.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: March 26, 2019
    Assignee: Brandeis University
    Inventors: Lawrence J. Wangh, Kenneth E. Pierce, Jesus A. Sanchez, John E. Rice, Alexandra Isabel King Over, Adam E. Osborne
  • Detecting mutations in DNA
    Patent number: 9637790
    Abstract: Provided herein are methods for detecting mutations in nucleic acid, and compositions and kits for performing such methods. In particular, nucleic acid amplification and fluorescence detection methods are provided to detect mutations and assess the mutational load. The methods are based on a set of adjacently binding probes wherein one probe is labelled with a quencher and the other is a self-indicating probe labelled with fluorophore and quencher. The binding of the probes is analyzed by melting curve analysis.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: May 2, 2017
    Assignee: Brandeis University
    Inventors: Adam E. Osborne, Lawrence J. Wangh, John E. Rice
  • Mispriming Prevention Reagents
    Publication number: 20160265014
    Abstract: Provided herein are mispriming prevention reagents, compositions and kits comprising such reagents and methods of use thereof.
    Type: Application
    Filed: December 15, 2015
    Publication date: September 15, 2016
    Inventors: Lawrence J. Wangh, Kenneth E. Pierce, Jesus A. Sanchez, John E. Rice, Alexandra Isabel King Over, Adam E. Osborne
  • TREATMENT OF DNA DAMAGE AND MITOCHONDRIAL DYSFUNCTION USING PALM FRUIT JUICE
    Publication number: 20160000854
    Abstract: Methods, compositions and kits for the prevention and treatment of mitochondrial dysfunction, mitochondrial DNA damage and genomic DNA damage are provided. The methods use the administration of palm fruit juice and/or compositions containing phenolic compounds present in palm fruit juice. The methods, compositions, and kits can be used to reduce DNA damage in subjects being treated with nucleoside reverse transcriptase inhibitors, such as patients having HIV or AIDS.
    Type: Application
    Filed: February 6, 2014
    Publication date: January 7, 2016
    Inventors: Adam E. OSBORNE, Lawrence J. WANGH, Kenneth C. HAYES, Ravigadevi SAMBANTHAMURTHI
  • DETECTING MUTATIONS IN DNA
    Publication number: 20130344484
    Abstract: Provided herein are methods for detecting mutations in nucleic acid, and compositions and kits for performing such methods. In particular, nucleic acid amplification and fluorescence detection methods are provided to detect mutations and assess the mutational load. The methods are based on a set of adjacently binding probes wherein one probe is labelled with a quencher and the other is a self-indicating probe labelled with fluorophore and quencher. The binding of the probes is analysed by melting curve analysis.
    Type: Application
    Filed: December 1, 2011
    Publication date: December 26, 2013
    Applicant: BRANDEIS UNIVERSITY
    Inventors: Adam E. Osborne, Lawrence J. Wangh, John E. Rice