Abstract: The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with mutations in otoferlin (OTOF), by way of OTOF gene therapy. The disclosure provides a variety of compositions that include a first nucleic acid vector that contains a polynucleotide encoding an N-terminal portion of an OTOF protein and a second nucleic acid vector that contains a polynucleotide encoding a C-terminal portion of an OTOF protein. These vectors can be used to increase the expression of OTOF in a subject, such as a human subject suffering from sensorineural hearing loss.

Abstract: The disclosure relates to products and methods for improving the performance of cereal manufactured with silk solutions and powders containing silk fibroin obtained from silk inputs. The coatings, or otherwise incorporated silk fibroin, can be used to improve the shelf life of cereals, reduce the glycemic index of cereals, and to improve the performance of those cereals in areas valued by consumers.

Abstract: The disclosure relates to products and methods for improving the performance of cereal manufactured with silk solutions and powders containing silk fibroin obtained from silk inputs. The coatings, or otherwise incorporated silk fibroin, can be used to improve the shelf life of cereals, reduce the glycemic index of cereals, and to improve the performance of those cereals in areas valued by consumers.

Abstract: The present technology relates to artificial reality systems. Such systems provide projections a user can create to specify object interactions. For example, when a user wishes to interact with an object outside her immediate reach, she can use a projection to select, move, or otherwise interact with the distant object. The present technology also includes object selection techniques for identifying and disambiguating between objects, allowing a user to select objects both near and distant from the user. Yet further aspects of the present technology include techniques for interpreting various bimanual (two-handed) gestures for interacting with objects. The present technology further includes a model for differentiating between global and local modes for, e.g., providing different input modalities or interpretations of user gestures.

Abstract: The disclosure relates to products and methods for improving the performance of cereal manufactured with silk solutions and powders containing silk fibroin obtained from silk inputs. The coatings, or otherwise incorporated silk fibroin, can be used to improve the shelf life of cereals, reduce the glycemic index of cereals, and to improve the performance of those cereals in areas valued by consumers.

Abstract: A radiation source assembly (100) for an apparatus (110) for layer-by-layer formation of a three-dimensional object by the consolidation of particulate material, the radiation source assembly (100) comprising: a plurality of radiation sources (21), each radiation source (21) being operable to emit a respective beam of radiation (26) towards a build bed surface (12) of the apparatus (110); and one or more collimators (22) arranged to collimate the beams of radiation (26) to produce one or more collimated beams of radiation (27) and to direct said collimated beams (27) of radiation towards the particulate material on the build bed surface (12).

Abstract: Apparatus (1) for manufacturing a three-dimensional object from a powder, the apparatus comprising: a work surface (170); a build bed (201) having a build area (190), the build area (190) being comprised within the work surface (170), wherein successive layers of said three-dimensional object are formed in the build bed (201); a first powder supply module (2) fixedly arranged on a first side of the work surface (170), outward from a first side of the build bed (201); a second powder supply module (3) fixedly arranged on a second side of the work surface (170), outward from a second side of the build bed (201); a first powder distribution sled (300) operable to distribute powder dosed to the work surface (170) from the first powder supply module (2) while moving in a first direction from the first side of the work surface (170) towards the second side of the work surface (170), and from the second powder supply module (3) while moving in a second direction from the second side of the work surface (170) towards

Abstract: A method for the manufacture of three-dimensional objects is disclosed, utilising an independently operable printing sled (350) for sintering fusible powder and an independently operable powder distribution sled (300) for depositing a layer of fusible powder on the sintered layer. Since the printing sled and the powder distribution sled are independently operable, the time between sintering and deposition can be altered, dependent on the printing conditions and materials, resulting in an enhanced bond between the layers of the three-dimensional object.

Abstract: A hinge assembly is provided for pivotally mounting a door on a refrigerator cabinet. The refrigerator cabinet includes a top wall, a bottom wall, a pair of opposed side walls extending between the bottom and top wall, and a face that is normal to the top wall, bottom wall, and opposed side walls. The hinge assembly includes a hinge bracket, hinge pin, and door stop member. The hinge bracket is attachable to the cabinet and includes a threaded aperture having a first end and a second end. The hinge pin defines an axis about which the door can rotate and is threadably insertable into either end of the threaded aperture. The door stop member is configured to rotate about the axis and prohibit rotation of the door beyond a certain position.

Abstract: A drawer assembly is provided for a refrigeration appliance. The drawer assembly comprises a unitary storage bin configured to move relative to the cooled compartment. The storage bin is defined by a front wall, a rear wall and opposed sidewalls that are arranged substantially parallel to the first and second interior walls of the cooled compartment. An uppermost portion of each of the opposed sidewalls comprises a projecting edge. The rear wall comprises a reinforced edge that inhibits deflection. A pair of linear motion elements is installed to enable movement of the storage bin in and out of the cooled compartment. A pair of support brackets couples the pair of linear motion elements.

Abstract: A storage system for storing food items in a temperature-controlled environment includes a rail attached to a liner panel. The rail includes at least one mounting structure that passes through an aperture in the liner panel. A bin has an arm extending from a rear surface of the bin. The bin is placed in a storage position. The arm is placed between the rail and the liner panel when the bin is placed in the storage position. Another example of the storage system and refrigeration appliance includes a foot extending from a rear surface of the bin. Yet another example includes interaction between a bin tab and a plurality of bumps on the rail to prevent side to side motion.

Abstract: Provided is a refrigeration appliance including a refrigerated compartment, and a plurality of doors that, when closed, cooperate with each other to collectively enclose an entrance into the refrigerated compartment. A mullion is pivotally coupled to a distal side of a first door included in the plurality of doors, and is pivotal between an open orientation when the first door is open and a closed orientation in which a seal is established between the mullion and a second door when the doors are closed. A roller is provided adjacent to an end of the mullion, and includes a rubberized material that extends about at least a portion of an exterior periphery of the roller. A receiver with an arcuate surface over which the exterior periphery of the roller with the rubberized material travels to adjust the mullion between the open orientation and the closed orientation is also provided.

Abstract: A drawer assembly is provided for a refrigeration appliance. The drawer assembly comprises a unitary storage bin configured to move relative to the cooled compartment. The storage bin is defined by a front wall, a rear wall and opposed sidewalls that are arranged substantially parallel to the first and second interior walls of the cooled compartment. An uppermost portion of each of the opposed sidewalls comprises a projecting edge. The rear wall comprises a reinforced edge that inhibits deflection. A pair of linear motion elements is installed to enable movement of the storage bin in and out of the cooled compartment. A pair of support brackets couples the pair of linear motion elements.

Abstract: Provided is a storage system and a refrigeration appliance including the storage system for storing food items in a temperature-controlled environment. The storage system includes a rail attached to a liner panel. The rail includes at least one mounting structure configured to pass through an aperture in the liner panel. A bin has an arm extending from a rear surface of the bin. The bin is placed in a storage position. The arm is placed between the rail and the liner panel when the bin is placed in the storage position. Another example of the storage system and refrigeration appliance includes a foot extending from a rear surface of the bin. Yet another example includes interaction between a bin tab and a plurality of bumps on the rail to prevent side to side motion.

Abstract: A door for a refrigerator appliance is pivotally connected by a hinge. The door includes a polygonal shell having corners and defining at least part of a cavity therein and a hinge bearing mounted to the polygonal shell adjacent one of the corners. The hinge bearing extends into the cavity and defines a generally cylindrical passage to receive and journal a hinge pin of the refrigerator appliance. A reinforcement tube is secured to the hinge bearing and extends a distance within the cavity. The reinforcement tube includes a sidewall that defines a hollow interior, and at least one hole extends through the sidewall to provide communication between the cavity and the hollow interior. Insulation is foamed in place that substantially fills the cavity including the corner, and the insulation penetrates into the hollow interior of the reinforcement tube via the at least one hole.

Abstract: A drawer assembly is provided for a refrigeration appliance. The drawer assembly comprises a unitary storage bin configured to move relative to the cooled compartment. The storage bin is defined by a front wall, a rear wall and opposed sidewalls that are arranged substantially parallel to the first and second interior walls of the cooled compartment. An uppermost portion of each of the opposed sidewalls comprises a projecting edge. The rear wall comprises a reinforced edge that inhibits deflection. A pair of linear motion elements is installed to enable movement of the storage bin in and out of the cooled compartment. A pair of support brackets couples the pair of linear motion elements.

Abstract: Provided is a storage system and a refrigeration appliance including the storage system for storing food items in a temperature-controlled environment. The storage system includes a rail attached to a liner panel. The rail includes at least one mounting structure configured to pass through an aperture in the liner panel. A bin has an arm extending from a rear surface of the bin. The bin is placed in a storage position. The arm is placed between the rail and the liner panel when the bin is placed in the storage position. Another example of the storage system and refrigeration appliance includes a foot extending from a rear surface of the bin. Yet another example includes interaction between a bin tab and a plurality of bumps on the rail to prevent side to side motion.

Abstract: A refrigerator assembly includes a cabinet having one or more compartments and a door configured to provide access to the one or more compartments. The refrigerator assembly further includes a mullion portion movably attached with respect the door and a hinge assembly attaching the mullion portion to the door such that the mullion portion is rotatably movable with respect to the door about a rotational axis between a first position and a second position. The refrigerator assembly further includes a leaf spring and a cam structure. The cam structure includes a first recess for receiving the leaf spring when the mullion portion is in the first position. The cam structure further includes a second recess for receiving the leaf spring when the mullion portion is in the second position.

Abstract: A drawer assembly is provided for a refrigeration appliance. The drawer assembly comprises a unitary storage bin configured to move relative to the cooled compartment. The storage bin is defined by a front wall, a rear wall and opposed sidewalls that are arranged substantially parallel to the first and second interior walls of the cooled compartment. An uppermost portion of each of the opposed sidewalls comprises a projecting edge. The rear wall comprises a reinforced edge that inhibits deflection. A pair of linear motion elements is installed to enable movement of the storage bin in and out of the cooled compartment. A pair of support brackets couples the pair of linear motion elements.

Abstract: A refrigerator assembly includes a cabinet having one or more compartments and a door configured to provide access to the one or more compartments. The refrigerator assembly further includes a mullion portion movably attached with respect the door and a hinge assembly attaching the mullion portion to the door such that the mullion portion is rotatably movable with respect to the door about a rotational axis between a first position and a second position. The refrigerator assembly further includes a leaf spring and a cam structure. The cam structure includes a first recess for receiving the leaf spring when the mullion portion is in the first position. The cam structure further includes a second recess for receiving the leaf spring when the mullion portion is in the second position.