Abstract: The present disclosure provides methods of identifying a subject suitable for an immunooncology (I-O) therapy comprising measuring the expression of one or more genes of a pantumor inflammation gene panel. In some aspects, the method further comprises administering an I-O therapy to the subject. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.

Abstract: The present disclosure provides methods of identifying a subject suitable for an immunooncology (I-O) therapy comprising measuring the expression of one or more of STAT1, IFN?, NECTIN2, and CSFIR. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.

Abstract: The present disclosure provides methods of identifying a subject suitable for an immuno-oncology (I-O) therapy comprising measuring the expression of one or more of STAT1, IFN?, NECTIN2, and CSF1R. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.

Abstract: The present invention is directed to a method of making Internet network trafficking easier and more secure while resolving a DNS inquiry in systems having both IPv4 and IPv6 elements in the new world situation of two competing DNS systems. The method utilizes a computing system DNS transfer policy to inquire and then provide a response to DNS inquiries that can include differing Internet Protocols. By including the policy inquiry and allowing the system to encode IPv4 addresses within IPv6 addresses, a more secure and quick response is provided allowing business, government and individual users to safely use the Internet in association with any number of Internet capable devices.

Abstract: A computer-implemented method for dynamically directing mobile device traffic in a computing system programmed to perform the method includes receiving with the computing system, a request for resolution of a domain name associated with a web address from a mobile device, determining in the computing system, whether the domain name is not subject to security policies, determining in the computing system, a publically-accessible IP address associated with the domain name, when the domain name is determined to not be subject to the security policies, the method comprises providing from the computing system, the publically-accessible IP address associated with the domain name to the mobile, and when the domain name is determined to be subject to the security policies, the method comprises providing from the computing system, an IP address associated with the computing system to the mobile.