Abstract: A method and system for automatically analyzing the impact of a treatment of interest is disclosed. Data related to a treatment of interest and a population including a treated group and a non-treated group is received. Propensity scores are estimated for the treated group and the non-treated group. Subgroups of the treated group and the non-treated group are matched based on the propensity scores. An outcome model is generated for each subgroup of the non-treated group, and an impact of the treatment on the treated group is generated for each subgroup of the treated group using the outcome model generated for the matching subgroup of the control group. Outcome models may be generated for the treated group and the non-treated group, and an impact of the treatment on the population may be generated based on the propensity scores and the outcome models for the test group and the non-treated group.