Abstract: An improved x-ray brachytherapy system and related methods for delivering low dose radiation to a treatment location while minimizing damage to surrounding healthy tissue. Generally, the x-ray brachytherapy system can include a device controller, a device positioner, system imagery, and an x-ray brachytherapy probe having two or more delivery needles. The two or more delivery needles are operably coupled to at least one probe housing such that a tip spacing between the delivery needles is minimized when positioned at the treatment location. By reducing tip spacing at the treatment location, smaller radiation doses can be delivered so as to limit radiation exposure to surrounding healthy tissue.