Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

Abstract: A method of supporting a pressure bearing wall against a pressure differential applied across the wall can include positioning a support structure proximate the pressure bearing wall, the support structure having a support surface formed thereon, and the support surface contacting the pressure bearing wall and supporting the wall against the pressure differential. A pressure bearing housing assembly can include a pressure bearing wall and a support structure which supports the pressure bearing wall against a pressure differential applied across the wall. A well system can comprise a well tool including a pressure bearing housing assembly exposed to pressure in a wellbore, whereby a pressure differential is applied across a pressure bearing wall of the housing assembly, the pressure bearing wall being supported against the pressure differential by a support structure.

Abstract: A method of supporting a pressure bearing wall against a pressure differential applied across the wall can include positioning a support structure proximate the pressure bearing wall, the support structure having a support surface formed thereon, and the support surface contacting the pressure bearing wall and supporting the wall against the pressure differential. A pressure bearing housing assembly can include a pressure bearing wall and a support structure which supports the pressure bearing wall against a pressure differential applied across the wall. A well system can comprise a well tool including a pressure bearing housing assembly exposed to pressure in a wellbore, whereby a pressure differential is applied across a pressure bearing wall of the housing assembly, the pressure bearing wall being supported against the pressure differential by a support structure.

Abstract: A well tool with combined actuation of multiple valves. A well tool includes at least two valves and an actuator which actuates each of the valves, one valve being positioned longitudinally between the other valve and the actuator, and the other valve being operable in response to displacement of an operating device by the actuator. Another well tool includes a valve with a closure which displaces when the valve is operated, a volume of a chamber which increases and a volume of another chamber which decreases when the closure displaces, and a pressure differential between the chambers being substantially zero when the closure displaces. Another well tool includes at least two valve closures which are the only displaceable components of the well tool exposed to a first internal flow passage portion when one closure prevents fluid communication between the first and a second internal flow passage portions.

Abstract: An actuator control system includes a housing assembly having at least one line therein for controlling operation of an actuator, and a modular controller attached externally to the housing assembly and interconnected to the line. A method of constructing an actuator control system includes the steps of: assembling a modular controller, the modular controller including a control valve therein for controlling operation of an actuator via a hydraulic line; testing the modular controller, including functionally testing the control valve; and then attaching the modular controller to a housing assembly having the line formed therein. Another actuator control system includes a housing assembly having at least one line therein for controlling operation of an actuator, and a modular controller attached separately to the housing assembly and interconnected to the line via a manifold of the modular controller, the manifold including a concave interface surface which receives the housing assembly therein.

Abstract: An actuator control system includes a housing assembly having at least one line therein for controlling operation of an actuator, and a modular controller attached externally to the housing assembly and interconnected to the line. A method of constructing an actuator control system includes the steps of: assembling a modular controller, the modular controller including a control valve therein for controlling operation of an actuator via a hydraulic line; testing the modular controller, including functionally testing the control valve; and then attaching the modular controller to a housing assembly having the line formed therein. Another actuator control system includes a housing assembly having at least one line therein for controlling operation of an actuator, and a modular controller attached separately to the housing assembly and interconnected to the line via a manifold of the modular controller, the manifold including a concave interface surface which receives the housing assembly therein.

Abstract: A method of actuating a well tool utilizing first and second pressure sources includes the steps of: placing an actuator chamber in communication with the first pressure source, thereby displacing a piston from a first position to a second position; and then placing another chamber in communication with the second pressure source, thereby displacing the piston to a third position. A multi-position actuator includes an operating member which displaces to operate a well tool, a first position of the operating member corresponding to a pressure source being in communication with a chamber and another pressure source being in communication with another chamber, a second position of the operating member corresponding to the same pressure source being in communication with both of the chambers, and a third position of the operating member corresponding to the pressure sources being connected to the chambers oppositely to that of the first position.

Abstract: An actuator control system includes a housing assembly having at least one line therein for controlling operation of an actuator, and a modular controller attached externally to the housing assembly and interconnected to the line. A method of constructing an actuator control system includes the steps of: assembling a modular controller, the modular controller including a control valve therein for controlling operation of an actuator via a hydraulic line; testing the modular controller, including functionally testing the control valve; and then attaching the modular controller to a housing assembly having the line formed therein. Another actuator control system includes a housing assembly having at least one line therein for controlling operation of an actuator, and a modular controller attached separately to the housing assembly and interconnected to the line via a manifold of the modular controller, the manifold including a concave interface surface which receives the housing assembly therein.

Abstract: A well tool with combined actuation of multiple valves. A well tool includes at least two valves and an actuator which actuates each of the valves, one valve being positioned longitudinally between the other valve and the actuator, and the other valve being operable in response to displacement of an operating device by the actuator. Another well tool includes a valve with a closure which displaces when the valve is operated, a volume of a chamber which increases and a volume of another chamber which decreases when the closure displaces, and a pressure differential between the chambers being substantially zero when the closure displaces. Another well tool includes at least two valve closures which are the only displaceable components of the well tool exposed to a first internal flow passage portion when one closure prevents fluid communication between the first and a second internal flow passage portions.

Abstract: A method of actuating a well tool utilizing first and second pressure sources includes the steps of: placing an source, thereby displacing a piston from a first position to a second position; and then placing another chamber in communication with the second pressure source, thereby displacing the piston to a third position. A multi-position actuator includes an operating member which displaces to operate a well tool, a first position of the operating member corresponding to a pressure source being in communication with a chamber and another pressure source being in communication with another chamber, a second position of the operating member corresponding to the same pressure source being in communication with both of the chambers, and a third position of the operating member corresponding to the pressure sources being connected to the chambers oppositely to that of the first position.

Abstract: An actuator control system includes a housing assembly having at least one line therein for controlling operation of an actuator, and a modular controller attached externally to the housing assembly and interconnected to the line. A method of constructing an actuator control system includes the steps of: assembling a modular controller, the modular controller including a control valve therein for controlling operation of an actuator via a hydraulic line; testing the modular controller, including functionally testing the control valve; and then attaching the modular controller to a housing assembly having the line formed therein. Another actuator control system includes a housing assembly having at least one line therein for controlling operation of an actuator, and a modular controller attached separately to the housing assembly and interconnected to the line via a manifold of the modular controller, the manifold including a concave interface surface which receives the housing assembly therein.