Abstract: Devices and methods are described herein for directly and accurately measuring sweat flow rates using miniaturized thermal flow rate sensors. The devices (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500) include the flow rate sensors (220, 320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320, 1420) in or adjacent to a microfluidic component (230, 330, 430, 530, 630, 730, 830, 930, 1030, 1130, 1230, 1330, 1430, 1530) of a wearable sweat sensing device. The devices and methods optimize the sensitivity of the flow rate sensors, while minimizing the presence of noise, in order to accurately and directly measure sweat flow rates.

Abstract: Devices and methods are described herein for directly and accurately measuring sweat flow rates using miniaturized thermal flow rate sensors. The devices (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500) include the flow rate sensors (220, 320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320, 1420) in or adjacent to a microfluidic component (230, 330, 430, 530, 630, 730, 830, 930, 1030, 1130, 1230, 1330, 1430, 1530) of a wearable sweat sensing device. The devices and methods optimize the sensitivity of the flow rate sensors, while minimizing the presence of noise, in order to accurately and directly measure sweat flow rates.

Abstract: Devices and methods are described herein for directly and accurately measuring sweat flow rates using miniaturized thermal flow rate sensors. The devices (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500) include the flow rate sensors (220, 320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320, 1420) in or adjacent to a microfluidic component (230, 330, 430, 530, 630, 730, 830, 930, 1030, 1130, 1230, 1330, 1430, 1530) of a wearable sweat sensing device. The devices and methods optimize the sensitivity of the flow rate sensors, while minimizing the presence of noise, in order to accurately and directly measure sweat flow rates.

Abstract: Devices and methods are described herein for directly and accurately measuring sweat flow rates using miniaturized thermal flow rate sensors. The devices (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500) include the flow rate sensors (220, 320, 420, 520, 620, 720, 820, 920, 1020, 1120, 1220, 1320, 1420) in or adjacent to a microfluidic component (230, 330, 430, 530, 630, 730, 830, 930, 1030, 1130, 1230, 1330, 1430, 1530) of a wearable sweat sensing device. The devices and methods optimize the sensitivity of the flow rate sensors, while minimizing the presence of noise, in order to accurately and directly measure sweat flow rates.

Abstract: A device (100) for sensing sweat on skin (12) includes a first analyte-specific sensor (120, 122) for sensing a first analyte in sweat; a sweat stimulating component (140); a waste collector (142, 144, 146, 148) beneath the sweat stimulating component (140); and an additional component being one or more of a sweat collector (130, 132, 134) or an additional analyte-specific sensor (124) for sensing an additional analyte in sweat that is different from the first analyte, the additional component being adjacent to and fluidically isolated from the waste collector (142, 144, 146, 148). A device (200) for sensing sweat on skin (12) includes a first portion comprising a first analyte-specific sensor (220) for sensing a first analyte in stimulated sweat and a sweat stimulating component (240); and a second portion comprising a second analyte-specific sensor (225, 226) for sensing a second analyte in natural sweat.

Abstract: A sensor including a flexible substrate, a conductor disposed on the flexible substrate, and a hydrophilic surface coating disposed on the conductor. The flexible substrate and the conductor form wrinkle as a result of the substrate being shrunk. The hydrophilic surface coating is disposed in, e.g., fills, the wrinkles or covers surface areas of the conductor within invaginations of the wrinkles. Also disclosed are methods of preparing the sensor and methods of detecting an amount of an analyte in an aqueous solution. Methods of detecting an amount of analyte can include contacting the sensor with an aqueous solution, and detecting an electrical signal with the sensor, wherein the electrical signal is indicative of the amount of the analyte.