Patents by Inventor Adam Henry Marblestone

Adam Henry Marblestone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240264163
    Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
    Type: Application
    Filed: January 17, 2024
    Publication date: August 8, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Edward BOYDEN, Adam Henry MARBLESTONE, Samuel Gordon RODRIQUES
  • Patent number: 11906525
    Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: February 20, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Edward Boyden, Adam Henry Marblestone, Samuel Gordon Rodriques
  • Publication number: 20220291226
    Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
    Type: Application
    Filed: May 25, 2022
    Publication date: September 15, 2022
    Applicant: Massachusetts Institute of Technology
    Inventors: Edward BOYDEN, Adam Henry MARBLESTONE, Samuel Gordon RODRIQUES
  • Patent number: 11346842
    Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: May 31, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Edward Boyden, Adam Henry Marblestone, Samuel Gordon Rodriques
  • Publication number: 20210395796
    Abstract: The present invention relates to a method for amplifying at least one target RNA in a fixed and, optionally, expanded biological sample. In an embodiment of the invention, the method comprises incubating the fixed biological sample with a pair of polynucleotides complementary to non-overlapping and proximal sequences of a target RNA, wherein the polynucleotide pair hybridizes to the target RNA; ligating the polynucleotide pair using a ligase; and amplifying the ligation product. The invention further provides methods for detecting and optionally quantifying and/or sequencing the amplification product. As the method comprises hybridizing polynucleotide pairs to a target RNA in a fixed biological sample, the target RNA can be hybridized in situ.
    Type: Application
    Filed: April 30, 2021
    Publication date: December 23, 2021
    Inventors: Fei Chen, Asmamaw Wassie, Shahar Alon, Adam Henry Marblestone, Anubhav Sinha, Andrew C. Payne, Edward Stuart Boyden
  • Patent number: 10995361
    Abstract: The present invention relates to a method for amplifying at least one target RNA in a fixed and, optionally, expanded biological sample. In an embodiment of the invention, the method comprises incubating the fixed biological sample with a pair of polynucleotides complementary to non-overlapping and proximal sequences of a target RNA, wherein the polynucleotide pair hybridizes to the target RNA; ligating the polynucleotide pair using a ligase; and amplifying the ligation product. The invention further provides methods for detecting and optionally quantifying and/or sequencing the amplification product. As the method comprises hybridizing polynucleotide pairs to a target RNA in a fixed biological sample, the target RNA can be hybridized in situ.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: May 4, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Fei Chen, Asmamaw T. Wassie, Shahar Alon, Adam Henry Marblestone, Anubhav Sinha, Andrew Payne, Edward Stuart Boyden
  • Publication number: 20200400677
    Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.
    Type: Application
    Filed: June 22, 2020
    Publication date: December 24, 2020
    Applicant: Massachusetts Institute of Technology
    Inventors: Edward BOYDEN, Adam Henry MARBLESTONE, Samuel Gordon RODRIQUES
  • Patent number: 10563257
    Abstract: The invention provides in situ nucleic acid sequencing to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ sequencing of nucleic acids as well as new methods for fluorescent in situ sequencing (FISSEQ) in a new process referred to herein as “expansion sequencing” (ExSEQ).
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: February 18, 2020
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Edward Stuart Boyden, Fei Chen, Shahar Alon, George Church, Paul Warren Tillberg, Adam Henry Marblestone, Evan R. Daugharthy
  • Publication number: 20190055597
    Abstract: The invention provides in situ nucleic acid sequencing to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ sequencing of nucleic acids as well as new methods for fluorescent in situ sequencing (FISSEQ) in a new process referred to herein as “expansion sequencing” (ExSEQ).
    Type: Application
    Filed: August 23, 2018
    Publication date: February 21, 2019
    Inventors: Edward Stuart Boyden, Fei Chen, Shahar Alon, George Church, Paul Warren Tillberg, Adam Henry Marblestone, Evan R. Daugharthy
  • Publication number: 20180216161
    Abstract: The present invention relates to a method for amplifying at least one target RNA in a fixed and, optionally, expanded biological sample. In an embodiment of the invention, the method comprises incubating the fixed biological sample with a pair of polynucleotides complementary to non-overlapping and proximal sequences of a target RNA, wherein the polynucleotide pair hybridizes to the target RNA; ligating the polynucleotide pair using a ligase; and amplifying the ligation product. The invention further provides methods for detecting and optionally quantifying and/or sequencing the amplification product. As the method comprises hybridizing polynucleotide pairs to a target RNA in a fixed biological sample, the target RNA can be hybridized in situ.
    Type: Application
    Filed: January 22, 2018
    Publication date: August 2, 2018
    Inventors: Fei Chen, Asmamaw T. Wassie, Shahar Alon, Adam Henry Marblestone, Anubhav Sinha, Andrew Payne, Edward Stuart Boyden