Patents by Inventor Adam J. Dupuy

Adam J. Dupuy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IDENTIFICATION OF T-CELL TRAFFICKING GENES AND USES THEREOF FOR INCREASING INFILTRATION OF T-CELLS INTO SOLID TUMORS
    Publication number: 20200181574
    Abstract: Disclosed are compositions, kits, and methods for identifying genes that are involved in T-cell trafficking. In particular, the compositions, kits, and methods may be used to identify genes involved in T-cell trafficking and/or infiltration into tumors such as genes that encode immune checkpoint regulators and/or stimulatory agents. The disclosed compositions, kits, and methods utilize the Sleeping Beauty transposon system in a mouse tumor model to identify genes that are involved in T-cell trafficking and infiltration into tumors. The genes identified in the disclosed methods may provide immunotherapy targets in the tumor microenvironment. The identified genes may be utilized in order to develop therapies that enhance T-cell trafficking and infiltration into tumors and/or T-cell killing of tumors such as in chimeric antigen receptor (CAR) T cell therapies.
    Type: Application
    Filed: April 18, 2018
    Publication date: June 11, 2020
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Laura M. Rogers, George J. Weiner, Adam J. Dupuy
  • Transposon system and methods of use
    Patent number: 8227432
    Abstract: The present invention is directed to improved transposons and transposases. The present invention also includes gene transfer systems, methods of using the transposons and transposases, and compositions including the transposons and transposases.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: July 24, 2012
    Assignee: Regents of the University of Minnesota
    Inventors: Perry B. Hackett, Karl J. Clark, Zongbin Cui, Adam J. Dupuy, Aron M. Geurts, Geyi Liu
  • Transposon system and methods of use
    Publication number: 20040077572
    Abstract: The present invention is directed to improved transposons and transposases. The present invention also includes gene transfer systems, methods of using the transposons and transposases, and compositions including the transposons and transposases.
    Type: Application
    Filed: April 22, 2003
    Publication date: April 22, 2004
    Applicant: Regents of the University of Minnesota
    Inventors: Perry B. Hackett, Karl J. Clark, Zongbin Cui, Adam J. Dupuy, Aron M. Geurts, Geyi Liu