Patents by Inventor Adam J. Katz
Adam J. Katz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120208274Abstract: The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue.Type: ApplicationFiled: February 29, 2012Publication date: August 16, 2012Inventors: Adam J. Katz, Ramon Llull, J. William Futrell, Marc H. Hedrick, Prosper Benhaim, Hermann Peter Lorenz, Min Zhu, Patricia Zuk, Peter H. Ashjian
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Publication number: 20120183510Abstract: A method and device for creating hanging drop cell aggregates. The method and device includes a plurality of pegs that allow for high throughput culture of aggregates. Also disclosed are means of transferring formed aggregates to various destinations, such as well plates, scaffolding, tissues, or wounds. Use of the device permits aggregates to be prepared or created in larger quantities than current methods, and allows for them to be transferred more efficiently.Type: ApplicationFiled: June 30, 2010Publication date: July 19, 2012Applicant: University of Virginia Patent FoundationInventors: Blair Taylor Stocks, Shayn Peirce Cottler, Adam J. Katz
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Publication number: 20110318833Abstract: The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.Type: ApplicationFiled: September 6, 2011Publication date: December 29, 2011Inventors: Adam J. Katz, Ramon Llull, J. William Futrell, Marc H. Hedrick, Prosper Benhaim, Hermann Peter Lorenz, Min Zhu
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Patent number: 7932084Abstract: The present invention relates to adipose tissue-derived stem cells and to methods and compositions for enhancing growth and differentiation of such cells. The invention further relates to growing such cells in serum-free or low serum growth medium, and formulations thereof.Type: GrantFiled: September 8, 2006Date of Patent: April 26, 2011Assignee: University of Virginia Patent FoundationInventors: Adam J. Katz, Anna M. Parker
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Publication number: 20110059182Abstract: A sprayer device and related method that delivers multicellular aggregates in suspension. A purpose of the sprayer embodiment may be to deliver cells into chronic wound beds, and additional purposes of the sprayer include additional application in other cell delivery environments, such as during open-heart surgery or other surgeries where it may be desirable to treat internal organs with aggregates of stem cells.Type: ApplicationFiled: February 5, 2009Publication date: March 10, 2011Applicant: University of Virginia Patent FoundationInventors: Shayn Peirce Cottler, Adam J. Katz, Peter Stapor, Peter J. Amos
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Publication number: 20110027879Abstract: The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue.Type: ApplicationFiled: January 26, 2010Publication date: February 3, 2011Inventors: Adam J. Katz, Ramon Llull, J. William Futrell, Marc H. Hedrick, Prosper Benhaim, Hermann Peter Lorenz, Min Zhu, Patricia Zuk, Peter H. Ashjian
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Publication number: 20100183519Abstract: This invention relates to therapeutic compositions comprising a surface active copolymer, such as poloxamer-188, in an amount effective to enhance microvascular blood flow and/or inflammation in injured skin or other tissue, and methods of using the therapeutic compositions of the invention to inhibit decreased blood flow associated with an injury, disease, or disorder.Type: ApplicationFiled: June 6, 2008Publication date: July 22, 2010Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Adam J. Katz, George T. Rodeheaver
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Publication number: 20100173411Abstract: The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.Type: ApplicationFiled: December 18, 2009Publication date: July 8, 2010Inventors: Adam J. Katz, Ramon Llull, J. William Futrell, Marc H. Hedrick, Prosper Benhaim, Hermann Peter Lorenz, Min Zhu
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Publication number: 20100111897Abstract: The invention provides compositions and methods useful for treating wounds and enhancing wound healing, particularly for diabetic wound healing.Type: ApplicationFiled: October 5, 2007Publication date: May 6, 2010Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Adam J. Katz, Anna M. Parker
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Publication number: 20100112031Abstract: The present application provides compositions and methods for regulating ECM production in ASCs and for isolating and using the various ECM molecules. The present application further provides methods for inducing various growth factors, cytokines and stem cell markers.Type: ApplicationFiled: October 16, 2009Publication date: May 6, 2010Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventor: Adam J. KATZ
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Publication number: 20100098739Abstract: Adipose tissue-derived stromal cells induced to form multicellular aggregates can be formed reliably and consistently, they can be maintained for prolonged periods in adherent or suspension culture, and they are able to survive, grow, and/or differentiate in serum-free media conditions. The present invention provides compositions and methods for the use of such aggregates in tissue repair. This culture platform provides a controlled and defined system in which to study and standardize adult stem cell biology, and begets an instinctive “modular” approach to the predictable replacement and regeneration of adipose tissue.Type: ApplicationFiled: October 16, 2009Publication date: April 22, 2010Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Adam J. KATZ, Hulan SHANG
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Publication number: 20090304643Abstract: The invention provides compositions and methods for preparing and characterizing multipotential mesenchymal stem cell aggregates. The invention further provides methods for using stem cell aggregates of the invention.Type: ApplicationFiled: January 30, 2007Publication date: December 10, 2009Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Moshe Khurgel, Adam J. Katz
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Publication number: 20090181456Abstract: The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue.Type: ApplicationFiled: December 8, 2008Publication date: July 16, 2009Inventors: Marc H. Hedrick, Adam J. Katz, Ramon Lluil, J. William Futrell, Prosper Benhaim, Hermann Peter Lorenz, Min Zhu
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Patent number: 7470537Abstract: The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides an adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue.Type: GrantFiled: December 17, 2003Date of Patent: December 30, 2008Inventors: Marc H. Hedrick, Adam J. Katz, Ramón Llull, J. William Futrell, Prosper Benhaim, Hermann Peter Lorenz, Min Zhu
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Publication number: 20080248003Abstract: The present invention relates to adipose tissue-derived stem cells and to methods and compositions for enhancing growth and differentiation of such cells. The invention further relates to growing such cells in serum-free or low serum growth medium, and formulations thereof.Type: ApplicationFiled: September 8, 2006Publication date: October 9, 2008Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Adam J. Katz, Anna M. Parker
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Publication number: 20080213235Abstract: The present invention provides methods for growing and inducing perivascular cell differentiation of adipose tissue-derived stromal cells. The invention further provides methods for administering such adipose tissue-derived cells to a subject. The cells of the invention are useful for treating diseases, disorders, conditions, and injuries requiring new or enhanced angiogenesis, vascular remodeling, drug delivery, and tissue engineering.Type: ApplicationFiled: July 28, 2006Publication date: September 4, 2008Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATIONInventors: Adam J. Katz, Shayn Peirce Cottler
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Publication number: 20040171146Abstract: The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.Type: ApplicationFiled: March 9, 2004Publication date: September 2, 2004Applicants: University of Pittsburgh of the Commonwealth System of Higher Education, The Regents of the University of CaliforniaInventors: Adam J. Katz, Ramon Llull, J. William Futrell, Marc H. Hedrick, Prosper Benhaim, Hermann Peter Lorenz, Min Zhu
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Patent number: 6777231Abstract: The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.Type: GrantFiled: September 10, 2001Date of Patent: August 17, 2004Assignee: The Regents of the University of CaliforniaInventors: Adam J. Katz, Ramon Llull, William J. Futrell, Marc H. Hedrick, Prosper Benhaim, Hermann Peter Lorenz, Min Zhu
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Publication number: 20030082152Abstract: The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derivedlattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue.Type: ApplicationFiled: September 10, 2001Publication date: May 1, 2003Inventors: Marc H. Hedrick, Adam J. Katz, Ramon Llull, J. William Futrell, Prosper Benhaim, Hermann Peter Lorenz, Min Zhu
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Publication number: 20020076400Abstract: The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The invention also provides a method of isolating stem cells from adipose tissues. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.Type: ApplicationFiled: September 6, 2001Publication date: June 20, 2002Applicant: University of Pittsburgh of the Commonwealth System of Higher EducationInventors: Adam J. Katz, Ramon Llull, J. William Futrell, Marc H. Hedrick, Prosper Benhaim, Hermann Peter Lorenz, Min Zhu