Abstract: This invention relates to novel derivatives of 4-hydroxybutyric acid and prodrugs thereof, and pharmaceutically acceptable salts of the foregoing. This invention also provides pharmaceutical compositions comprising a compound of this invention and the use of such compositions in methods of treating narcolepsy, fibromyalgia, other disorders or conditions that are beneficially treated by improving nocturnal sleep or by administering sodium oxybate.

Abstract: The present subject matter relates to a method which includes positioning a bottom and top polymeric separator sheet on a working surface, with a substantially planar battery anode disposed therebetween; applying a pressure and an electrical current to a cutting and welding tool such that top and bottom polymeric separator sheets are welded into a bag and such that the bag is excised from the top and bottom separator sheets, with the battery anode disposed in the bag; stacking the battery anode and at least one cathode into a battery stack; and disposing the battery stack into a battery case having at least one feedthrough, with a first terminal connected to the battery stack through the at least one feedthrough, and with the battery case filled with an electrolyte, wherein the protrusion is defined by laser cutting the cutting and welding tool, machining the cutting and welding tool, or photochemical etching the cutting and welding tool.

Abstract: This invention relates to novel 4-aminoquinazolines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering inhibitors of the EGFR and HER-2.

Abstract: A method includes the step of providing a sheet of lithium and a sheet of substrate material. The method further includes the step of pressing the sheet of lithium and the sheet of substrate material together in a die, the die having at least one surface that includes a plurality of force concentrating features configured to create regions of relatively higher pressure and regions of relatively lower pressure in at least one of the sheet of lithium and the sheet of substrate material. In another embodiment, a method includes the steps of providing a sheet of lithium material and a substrate material, and applying force to the sheet of lithium and the sheet of substrate material to form a plurality of protrusions on at least one of the sheet of lithium and the sheet of substrate material. The method includes the further step of pressing at least a portion of the sheet of lithium to the substrate material with sufficient force to at least partially deform the protrusions.

Abstract: One embodiment of the present subject matter includes an assembly. The assembly includes a stripper plate having a stripper plate face and defining and elongate opening extending through the stripper plate face and into the stripper plate. A punch of the assembly is slidably disposed in the elongate opening, the punch having a punch profile shaped to conform to the elongate opening. The assembly includes a die in alignment with the stripper plate, the die having a die face opposed to the stripper plate face, the face defining a die opening which is substantially coextensive with the elongate opening of the stripper plate, the die defining a plurality of wetting lumens extending through the die, with each lumen terminating in the die face near the die opening, each of the lumens adapted to dispense a lubricant to the die face and along the die opening.

Abstract: A method of manufacturing a pressed powder electrode for an electrochemical power source for use with an implantable medical device is provided. The method includes surrounding a current collector with layered sections of electrode powder. The method also includes compacting the electrode powder against the current collector from opposite sides to form an electrode pellet using springs having spring constants calculated to relieve a gap difference in equal strokes from each side. The resulting electrode pellet includes a substantially centered collector. According to various embodiments, compacting the electrode powder includes compacting using at least two springs on opposite sides of the current collector. Compacting the electrode powder includes using at least one forced air supply to compact the powder, according to various embodiments. Other aspects and embodiments are provided herein.

Abstract: The present invention provides peptide-based phosphorylation catalysts (PBPC's) for the asymmetric monophosphorylation of cyclitols, particularly myo-inositols. The PBPC's of the invention effect a regio and enantioselective phosphorylation of a myo-inositol in a manner analogous to enzymatic kinases, thereby functioning as effective “kinase mimics.” Although orders of magnitude less complex in terms of structure than macromolecular proteins, the PBPC's of the invention control product formation with high enantioselectivity (>98% ee). The synthetic (+)-myo-inositol-1-phosphate is optically and spectroscopically equivalent to naturally occuring compound. The ability of the low molecular weight PBPC's of the present invention to mimic stereoselective enzymes represents a powerful approach toward catalytic asymmetric synthesis of biologically important molecules, and for mechanistic modeling of biochemical transformations to enable their use in drug applications.

Abstract: The present invention provides peptide-based phosphorylation catalysts (PBPC's) for the asymmetric monophosphorylation of cyclitols, particularly myo-inositols. The PBPC's of the invention effect a regio and enantioselective phosphorylation of a myo-inositol in a manner analogous to enzymatic kinases, thereby functioning as effective “kinase mimics.” Although orders of magnitude less complex in terms of structure than macromolecular proteins, the PBPC's of the invention control product formation with high enantioselectivity (>98% ee). The synthetic (+)-myo-inositol-1-phosphate is optically and spectroscopically equivalent to naturally occuring compound. The ability of the low molecular weight PBPC's of the present invention to mimic stereoselective enzymes represents a powerful approach toward catalytic asymmetric synthesis of biologically important molecules, and for mechanistic modeling of biochemical transformations to enable their use in drug applications.