Patents by Inventor Adam J. Ratner

Adam J. Ratner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment and prevention of infections
    Patent number: 9783580
    Abstract: The present invention is drawn to the nucleic and amino acid sequences encoding vaginolysin (VLY) toxin from Gardnerella vaginalis, and biologically active fragments and variants thereof. The invention is also directed to anti-VLY antibodies and to their use therapeutically and in a new ELISA assay of VLY toxin. Other embodiments of the invention are directed to VLY toxoids and to vaccines that use the new VLY toxoids as immunogens.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: October 10, 2017
    Assignee: The Trustees of Columbia University In the City of New York
    Inventor: Adam J. Ratner
  • Treatment and prevention of bacterial vaginosis and infections
    Patent number: 9198957
    Abstract: G. vaginalis infection, a major cause of bacterial vaginosis (BV), is associated with biofilm formation. The present invention relates to treatment of G. vaginalis infections and BV with DNase. DNase reduces biofilm formation and increases biofilm breakdown, both in a dose dependent manner. The present invention further relates to treating BV and G. vaginalis infections with a combination of DNase and an antibiotic known to treat these diseases.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: December 1, 2015
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Adam J. Ratner, Saul Hymes
  • Treatment and Prevention of Gardnerella Vaginalis Infections
    Publication number: 20150010579
    Abstract: The present invention is drawn to the nucleic and amino acid sequences encoding vaginolysin (VLY) toxin from Gardnerella vaginalis, and biologically active fragments and variants thereof. The invention is also directed to anti-VLY antibodies and to their use therapeutically and in a new ELISA assay of VLY toxin. Other embodiments of the invention are directed to VLY toxoids and to vaccines that use the new VLY toxoids as immunogens.
    Type: Application
    Filed: July 15, 2014
    Publication date: January 8, 2015
    Applicant: The Trustees of the University of Columbia in the City of New York
    Inventor: Adam J. Ratner
  • Treatment and prevention of infections
    Patent number: 8802112
    Abstract: The present invention is drawn to the nucleic and amino acid sequences encoding vaginolysin (VLY) toxin from Gardnerella vaginalis, and biologically active fragments and variants thereof. The invention is also directed to anti-VLY antibodies and to their use therapeutically and in a new ELISA assay of VLY toxin. Other embodiments of the invention are directed to VLY toxoids and to vaccines that use the new VLY toxoids as immunogens.
    Type: Grant
    Filed: March 16, 2009
    Date of Patent: August 12, 2014
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Adam J. Ratner
  • Treatment and Prevention of Bacterial Vaginosis and Gardnerella Vaginalis Infections
    Publication number: 20130309219
    Abstract: G. vaginalis infection, a major cause of bacterial vaginosis (BV), is associated with biofilm formation. The present invention relates to treatment of G. vaginalis infections and BV with DNase. DNase reduces biofilm formation and increases biofilm breakdown, both in a dose dependent manner. The present invention further relates to treating BV and G. vaginalis infections with a combination of DNase and an antibiotic known to treat these diseases.
    Type: Application
    Filed: January 30, 2012
    Publication date: November 21, 2013
    Inventors: Adam J. Ratner, Saul Hymes
  • TREATMENT AND PREVENTION OF GARDNERELLA VAGINALIS INFECTIONS
    Publication number: 20110020355
    Abstract: The present invention is drawn to the nucleic and amino acid sequences encoding vaginolysin (VLY) toxin from Gardnerella vaginalis, and biologically active fragments and variants thereof. The invention is also directed to anti-VLY antibodies and to their use therapeutically and in a new ELISA assay of VLY toxin. Other embodiments of the invention are directed to VLY toxoids and to vaccines that use the new VLY toxoids as immunogens.
    Type: Application
    Filed: March 16, 2009
    Publication date: January 27, 2011
    Applicant: COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventor: Adam J. Ratner