Abstract: A system and method for assessing brain health includes presenting a saccade test to a subject and capturing biological sensor data of the subject in response to the saccade test using a plurality of biological sensors. Saccade cards are employed to measure the brain health of a subject through collection of eye tracking data, for example. Saccade cards using a variety of design elements besides numbers are used for collection of the eye tracking data and other biological data. The captured biological data is used to create a multi-variate signature of the brain health condition of the subject.

Abstract: The present invention provides novel peptides, compositions, and methods for creating quantitative novel compositions, as well as methods for creating quantitative standards to calibrate analytes. These peptides, compositions, and methods enable the creation of standards and calibrators for analyzing analytes and measuring clinical biomarkers (e.g., Tau). Also provided are kits comprising the peptides or compositions described herein, for use in assays (e.g., sandwich immunoassays).

Abstract: A system for assessing brain health of a user includes an electronics module including an active brainwave sensor that collects channels of electroencephalography (EEG) brainwave data, a plurality of biological sensors, and a stimulation device. The biological sensors include a microphone that captures verbal responses of the subject during a battery of tasks, an image sensor that records eye positions, eye saccade and other biometric identification information, an accelerometer, a gyrometer, a thermometer, a pulse oximetry sensor, a dermal skin conductance sensor, and key strokes, mouse clicks or touch events to measure cognitive data of the user. The stimulation device applies a battery of tasks including a visual or photic stimulant, an auditory stimulant, a gastronomic stimulant, an olfactory stimulant, a touch stimulant, and a cognitive challenge stimulant to the user. The plurality of biological sensors simultaneously measure the body's response to stimulants for recordation by the electronics module.

Abstract: A system and method for modeling bio-signals in the form of non-linear stochastic oscillators by extracting time series data from a subject into a series of summary fit parameters and comparing the unknown fit parameters to a set of normative fit parameters to determine whether the subject should be included in a group or not. The method includes data collection, feature extraction and then comparison of fit parameters from a non-linear stochastic oscillator model to a normative standard to make the in or out determination for a particular group. The system includes a processor programmed to perform the steps of the method.

Abstract: A system synchronizes a PC exhibiting latency of operations to a biosensor enabled microcontroller with real-time clock by providing an encoding scheme that captures the subject's absolute reaction time transmits the subject's reaction time from the PC exhibiting latency to the microcontroller with real-time clock. The system includes a transmitter that transmits a stimulus signal from the PC exhibiting latency, an input device indicating the subject's response to the stimulus signal, an encoding circuit adapted to encode a difference in time between the stimulus signal and the subject's response to the stimulus signal, an emitter adapted to transmit the encoded difference signal representing the subject's reaction time, and a complementary receiver adapted to detect the encoded difference signal.

Abstract: Methods for diagnosing Autism and/or Autism Spectrum Disorder (ASD) of a subject include establishing baseline brain wave patterns of the subject by having the subject perform a series of task and measuring brain waves during the tasks using an EEG measurement device, applying a light stimulus or images to the subject's eyes and capturing eye movements and/or changes in facial expression in response to the light stimulus or images, and giving a neuropsychological and cognition battery of tasks to the subject to generate a provoked cognitive assessment of the subject. A processing device correlates the baseline brain wave patterns, eye movements and/or facial expressions, and provoked cognitive assessment of the subject to profile data indicative of Autism and/or ASD. The corresponding system may also include an auditory testing device that tests the subject's sensitivity to sound and records the subject's speech in response to verbal tasks.

Abstract: A device provides a user interface that includes a list of push-to-talk contacts, and receives, via the user interface, a gesture indicating a request to establish a push-to-talk call with a particular contact in the list of push-to-talk contacts. The device initiates the push-to-talk call with another device associated with the particular contact, and the push-to-talk call is initiated with the other device based on the gesture and directly from within the user interface. The device provides for display a visual indicator associated with the push-to-talk call.

Abstract: A system is provided for collecting medical data about a subject between visits to a health care professional. The system includes a medical records database that stores patient data for access by the health care professional and an interactive and distributed data collection system provided to a team of collaborators (doctors, parents, teachers, etc.) who are to collect data about the subject between visits to a health professional. The data collection system includes a plurality of mobile computing devices implementing a software application adapted to periodically collect symptoms data and activity data about the subject in response to prompts relating to the subject's condition, to enable chat discussions amongst the team of collaborators about the symptons and activities of the subject, and to periodcally forward the collected data in a report to the medical records database.

Abstract: A system synchronizes a PC exhibiting latency of operations to a biosensor enabled microcontroller with real-time clock by providing an encoding scheme that captures the subject's absolute reaction time transmits the subject's reaction time from the PC exhibiting latency to the microcontroller with real-time clock. The system includes a transmitter that transmits a stimulus signal from the PC exhibiting latency, an input device indicating the subject's response to the stimulus signal, an encoding circuit adapted to encode a difference in time between the stimulus signal and the subject's response to the stimulus signal, an emitter adapted to transmit the encoded difference signal representing the subject's reaction time, and a complementary receiver adapted to detect the encoded difference signal.

Abstract: A system and method for assessing brain health includes presenting a saccade test to a subject and capturing biological sensor data of the subject in response to the saccade test using a plurality of biological sensors. Saccade cards are employed to measure the brain health of a subject through collection of eye tracking data, for example. Saccade cards using a variety of design elements besides numbers are used for collection of the eye tracking data and other biological data. The captured biological data is used to create a multi-variate signature of the brain health condition of the subject.

Abstract: An approach for monitoring a sleeping subject includes receiving an input for specifying an attachment position of a monitoring device attached to a subject, calibrating a resting positioning of the subject based on the attachment position, analyzing sensor information collected from the monitoring device to determine a movement of the subject into a potentially dangerous position with respect to the calibrated resting position, wherein the monitoring device includes an array of sensors including an accelerometer, one or more biometric sensors, or a combination thereof.

Abstract: A system and method for modeling bio-signals in the form of non-linear stochastic oscillators by extracting time series data from a subject into a series of summary fit parameters and comparing the unknown fit parameters to a set of normative fit parameters to determine whether the subject should be included in a group or not. The method includes data collection, feature extraction and then comparison of fit parameters from a non-linear stochastic oscillator model to a normative standard to make the in or out determination for a particular group. The system includes a processor programmed to perform the steps of the method.

Abstract: A device provides a user interface that includes a list of push-to-talk contacts, and receives, via the user interface, a gesture indicating a request to establish a push-to-talk call with a particular contact in the list of push-to-talk contacts. The device initiates the push-to-talk call with another device associated with the particular contact, and the push-to-talk call is initiated with the other device based on the gesture and directly from within the user interface. The device provides for display a visual indicator associated with the push-to-talk call.

Abstract: An exemplary mobile application management system detects a first user input provided by a user while a first user interface associated with a first feature of a mobile application is displayed within an application display area of a display screen of a mobile computing device executing the mobile application. The first user input represents a request to transform the first user interface into a minimized widget associated with the first feature of the mobile application. The mobile application management system directs, in response to the first user input, the mobile computing device to concurrently display, in place of the first user interface, the minimized widget within a first region of the application display area and a second user interface associated with one or more additional features of the mobile application within a second region of the application display area.

Abstract: An approach for providing personalized information regarding one or more physiological conditions associated with a user is described. A personal health platform calculates a minimum value, a maximum value, or a combination thereof for a physiological condition of a user. The personal health platform senses a measured value for the physiological condition from the user. The personal health platform further presents a user interface depicting the measured value relative to the minimum value, the maximum value, a historical measured value for the user, or a combination thereof, wherein the user interface depicts the measured value, the minimum value, the maximum value, or a combination thereof on one or more ring-based graphical elements, and wherein the one or more ring-based graphical elements correspond to a measurement range for the physiological condition.

Abstract: An approach for providing diagnostic information regarding one or more impacts sustained by one or more users while the one or more users are participating in a team activity is described. A diagnostic platform detects one or more impacts sustained by a user, wherein the user is part of a team with one or more other users engaged in a team activity. The diagnostic platform generates a recommendation for a level of participation of the user, the one or more other users, or a combination thereof in the team activity based on the one or more impacts, a severity level of the one or more impacts, or a combination thereof. The diagnostic platform further presents the recommendation, a representation of the severity level, a representation of the level of participation, or a combination thereof in a user interface.

Abstract: An exemplary mobile application management system detects a first user input provided by a user while a first user interface associated with a first feature of a mobile application is displayed within an application display area of a display screen of a mobile computing device executing the mobile application. The first user input represents a request to transform the first user interface into a minimized widget associated with the first feature of the mobile application. The mobile application management system directs, in response to the first user input, the mobile computing device to concurrently display, in place of the first user interface, the minimized widget within a first region of the application display area and a second user interface associated with one or more additional features of the mobile application within a second region of the application display area.

Abstract: A multi-modal physiological assessment device and method enables the simultaneous recording and then subsequent analysis of multiple data streams of biological signal measurements to assess the health and function of the brain. Means and methods are provided to identify and leverage artifact samples within ID and 2D bio signal data streams to help create more accurate predictors and classifiers of brain health states and conditions. One sensor's data is used to gate the relevant portion of another bio sensor's data in order to reduce the noise and increase the signal-to-noise ratio. This is a form of phase locking for multimodal data streams for brain health assessment.

Abstract: A method of extracting brain frequency sub bands corresponding to a medical condition such as Alzheimer's Disease from EEG time series data of a patient includes the steps of applying wavelet transforms to the EEG time series data to generate a continuous wavelet transformation time series at each wavelet scale, calculating Wavelet Entropy (WE) and Sample Entropy (SE) directly from the Continuous Wavelet Transformation time series at each wavelet scale, calculating arithmetic or geometric means and accumulations across scale ranges of interest; and selecting data from major brain frequency sub-bands as candidate sets of extraction features for analysis as a diagnostic signature for the medical condition. Diagnostic signatures for Alzheimer's disease are found when values of WE or SE are in certain ranges when EEG data is collected and analyzed in connection with certain analytical tasks such as an Eyes Open task.

Abstract: The present invention provides novel peptides, compositions, and methods for creating quantitative novel compositions, as well as methods for creating quantitative standards to calibrate analytes. These peptides, compositions, and methods enable the creation of standards and calibrators for analyzing analytes and measuring clinical biomarkers (e.g., Tau). Also provided are kits comprising the peptides or compositions described herein, for use in assays (e.g., sandwich immunoassays).