Abstract: A method of deploying a multibranch stent graft at a target site having a main lumen and a first branch lumen is provided. The method includes advancing a catheter including a main body having a first portion and a second portion, the main body defining a first portal being pre-cannulated with a first guide member, partially deploying the first portion of the main body, advancing a first sheath along the first guide member through the first portal, advancing a first articulatable wire through the first sheath, positioning the first articulatable wire into a first branch lumen of the target site, partially deploying the second portion of the main body, fully deploying the first portion and the second portion of the main body, advancing a first side branch body along the first articulatable wire into the first branch lumen, and deploying the first side branch body in the first branch lumen.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

Abstract: The present invention is drawn to devices and systems for allergen detection in a sample. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. In some embodiments, the allergen detection utilizes aptamer nucleic acid molecules as detection agents. In some embodiments, the nucleic acids are conjugated to magnetic beads or solid surfaces such as glasses, microwells and microchips.

Abstract: Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

Abstract: Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

Abstract: Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.

Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.

Abstract: Systems and methods for nitric oxide (NO) generation systems are provided. In some embodiments, an NO generation system comprises at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas. The electrodes have elongated surfaces such that a plasma produced is carried by the flow of the reactant gas and glides along the elongated surfaces from a first end towards a second end of the electrode pair. A controller is configured to regulate the amount of NO in the product gas by the at least one pair of electrodes using one or more parameters as an input to the controller. The one or more parameters include information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which the product gas flows.

Abstract: The present invention is drawn to devices and systems for allergen detection in a sample. The allergen detection system includes a sampler, a disposable analysis cartridge and a detection device with an optimized optical system. In some embodiments, the allergen detection utilizes aptamer nucleic acid molecules as detection agents. In some embodiments, the nucleic acids are conjugated to magnetic beads or solid surfaces such as glasses, microwells and microchips.

Abstract: The present invention provides systems, devices, signaling polynucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The detection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluorescent signal. SPNs derived from aptamer that bind allergens are provided as detection agents. SPNs have a single open structure, and are labeled with a fluorophore. Changes in fluorescence polarization of SPNs upon the binding of allergens are measured to calculate the allergen content in a sample.

Abstract: Disclosed herein are apparatus and techniques for applying a device to a subject. Such apparatus and techniques may provide feedback to an operator and/or regulate the force used to apply the device, yielding an improved result. Particularly useful embodiments include apparatus and techniques for applying a medical device, such as a skin surface electrode or microneedle array, to a patient's tissue.

Abstract: Apparatus and techniques are provided for interfacing a device with a surface. The apparatus and techniques provide gel encapsulation and isolation mechanisms to extend the shelf-life of the preparation devices, allow for the use of more effective materials, and improve the quality of the contact between a device and an application surface. Particular embodiments of these apparatus and techniques suitable for use in medical contexts are also provided.

Abstract: Embodiments of the present disclosure relate to sensor designs or shapes configured to facilitate placement of sensor electrodes and, thus, proper positioning of the sensors on patients. According to certain embodiments, a sensor may include a substrate that includes multiple electrodes, where a first electrode is configured to be placed on a patient's temple and a second electrode is configured to be placed on a patient's forehead directly above a patient's eyebrow. The sensor may include a particular shape and a fixed distance between the first and second electrodes to facilitate proper angling and positioning of the first and second electrodes as well as the other electrodes (e.g., third and fourth electrodes). Other embodiments may include a method for positioning the sensor on the patient, including a monitor with help screens.

Abstract: Apparatus and techniques are provided for interfacing a device with a surface. The apparatus and techniques provide gel encapsulation and isolation mechanisms to extend the shelf-life of the preparation devices, allow for the use of more effective materials, and improve the quality of the contact between a device and an application surface. Particular embodiments of these apparatus and techniques suitable for use in medical contexts are also provided.

Abstract: Disclosed herein are apparatus and techniques for applying a device to a subject. Such apparatus and techniques may provide feedback to an operator and/or regulate the force used to apply the device, yielding an improved result. Particularly useful embodiments include apparatus and techniques for applying a medical device, such as a skin surface electrode or microneedle array, to a patient's tissue.

Abstract: The present disclosure describes systems and methods for creating sharp features within a mold. For example, three or more mold plates may be provided to create a single mold assembly. Each mold plate includes one or more mold cavities, each having one or more surfaces. The provided mold plates may be assembled to form the mold assembly having a combined mold cavity between adjacent mold cavities of the mold plates. Although none of the individual mold cavities of the mold plates include sharp features, when the mold assembly is assembled, a combined mold cavity will include sharp transitions (e.g., angles of less than 180 degrees, right angles, angles of less than 90 degrees, and so forth) between adjacent surfaces of the mold cavities. In certain embodiments, sets of mold plates may be re-aligned to create varying mold cavity geometries. In addition, in certain embodiments, a mold pin may be inserted into an inner volume of a mold plate to both create additional sharp transitions between adjacent surfaces.

Abstract: Embodiments of the present disclosure relate to sensor designs or shapes configured to facilitate placement of sensor electrodes and, thus, proper positioning of the sensors on patients. According to certain embodiments, a sensor may include a substrate that includes multiple electrodes, where a first electrode is configured to be placed on a patient's temple and a second electrode is configured to be placed on a patient's forehead directly above a patient's eyebrow. The sensor may include a particular shape and a fixed distance between the first and second electrodes to facilitate proper angling and positioning of the first and second electrodes as well as the other electrodes (e.g., third and fourth electrodes). Other embodiments may include a method for positioning the sensor on the patient, including a monitor with help screens.