Abstract: Some embodiments of the methods and compositions provided herein include cells having membrane-tethered, IL13 mutein-directed zetakine receptors, such as those which specifically bind to the IL-13 receptor alpha 2 (IL13Ra2) at a 50-fold higher affinity than wildtype IL-13, and methods of cell-based immunotherapy targeting cancer cells, such as cells of solid tumors, using these compositions. In some embodiments, the receptors include spacer regions, such as particular spacer regions designed to provide certain advantages.

Abstract: A synthetic fiber is disclosed, formed from a composition which is made of from about 1 to about 98 weight percent of at least one polyhydroxyalkanoate; from about 1 to about 10 weight percent of at least one nucleating agent selected from the group consisting of polyester waxes, behenamide, crodamide, stearamide, erucamide, pentaerythritol, dipentaerythritol, boron nitride, and mixtures thereof; and from about 0.1 to about 5 weight percent of at least one melt flow modifier selected from the group consisting of calcium stearate, zinc stearate, starch, diamide oligomers, organic peroxides, and mixtures thereof.

Abstract: Some embodiments of the methods and compositions provided herein include cells having membrane-tethered. IL13 mutein-directed zetakine receptors, such as those which specifically bind to the IL-13 receptor alpha 2 (IL13Ra2) at a 50-fold higher affinity than wild-type IL-13, and methods of cell-based immunotherapy targeting cancer cells, such as cells of solid tumors, using these compositions. In some embodiments, the receptors include spacer regions, such as particular spacer regions designed to provide certain advantages.

Abstract: A payload delivery device is an apparatus designed to facilitate the delivery of emergency items to a target location via aerial vehicles. The apparatus includes a base strap, a plurality of holder straps, and a plurality of cargo straps. The base strap serves as the central structure of the apparatus that supports the plurality of holder straps and the plurality of cargo straps. The plurality of holder straps includes several straps designed to retain a parachute and the devices necessary to facilitate the deployment of the parachute. The plurality of holder straps is also designed to facilitate the operation of the parachute while securing the parachute to the base strap. The plurality of cargo straps include several straps that secure the payload to the apparatus. The plurality of cargo straps can also be arranged to accommodate the shape and size of the payload to be delivered using the apparatus.

Abstract: A biaxially-oriented industrial or home compostable film web having at least 3 co-extruded layers selected from: a skin film layer, a sealant film layer, and a combination of a sealant film layer and a skin film layer, wherein each of the sealant film layer and skin film layer includes a blend of from 0 to about 80 wt. % polyhydroxyalkanoate (PHA) and from about 20 to about 100 weight percent polylactic acid (PLA), and, optionally, minor amounts of other biopolymers, other polymers, nucleating agents, chain extenders, fatty amides, and fillers; and a core film layer including a blend of from about 30 to about 80 wt. % polyhydroxalkanoate (PHA), from about 20 to about 40 wt. % polylactic acid (PLA), and, optionally, minor amounts of other biopolymers, other polymers, nucleating agents, chain extenders, fatty amides, and fillers.

Abstract: Embodiments of the disclosure include methods of manufacturing compositions comprising host cells. In some alternatives, a method comprises introducing into a host cell an isolated nucleic acid, such as a nucleic acid coding for an isolated polypeptide of an extracellular domain (ECD) of HER2 polypeptide. Some embodiments include culturing the host cells in a medium comprising at least one growth factor. Some embodiments include selecting the host cells for expression of ECD.

Abstract: Recombinant receptors with a binding domain that binds B cell activation factor receptor (BAFF-R) are disclosed. Recombinant receptors include chimeric antigen receptors (CAR) having an anti-BAFF-R binding domain, a transmembrane domain, a CD3?/4-1BB intracellular signaling domain, and a spacer. Methods and systems to treat BAFF-R-expressing cancers, such as mantle cell lymphoma (MCL), multiple myeloma (MM), acute lymphoblastic leukemia (ALL), and diffuse large B-cell lymphoma (DLBCL), are also provided. The recombinant receptors disclosed herein can bind and elicit cytotoxic effects even in low antigen density conditions.

Abstract: Disclosed herein are antibodies and antigen binding fragments thereof that specifically bind human CD4. Also disclosed are fusion proteins comprising a glycoprotein G of the Paramyxoviridae family and CD4 antibodies for targeting and transducing cells expressing CD4. Viral vectors and other compositions containing the fusion proteins, as well as methods of using the fusion proteins, are also disclosed.

Abstract: A cylinder lock includes tumbler pin assemblies and a secondary locking element associated with at least one of the pin assemblies. The secondary locking element is biased outwardly to engage a locking feature formed in the bore of the housing to prevent the plug from rotating within the bore. A portion of the associated primary pin assembly extends through the secondary locking element and into the keyway and is movable independently of the secondary locking element. The secondary locking element includes at least one control feature that is directly or indirectly engaged by a key inserted into the keyway to cause the secondary locking element to move inwardly toward the plug so that the secondary locking element disengages from the locking feature or to permit the secondary locking element to be moved inwardly toward the plug so that the secondary locking element can disengage from the locking feature.

Abstract: Embodiments of the methods and compositions provided herein relate to chimeric antigen receptors (CARs) that specifically bind to B7H3. Some embodiments relate to cell-based immunotherapy targeting tumors, such as tumors comprising B7H3+ cells.

Abstract: Provided are polycistronic vectors for co-expression of one or more tolerogenic factors, one or more CARs, and optionally one or more safety switches, as well as compositions comprising the same, cells comprising the same and methods of generating those cells, and methods of using the disclosed vectors, compositions, and cells to treat diseases such as cancer, diabetes, and neurological diseases.

Abstract: Systems for variable angle insertion of surgical fasteners relative to an orthopedic plate with locking of the surgical fastener relative to the plate upon insertion. The systems may include a pivot member secured relative to either the orthopedic plate or the fastener. In either regard, the pivot member may provide locking engagement with the plate to lockingly engage the fastener relative to the plate.

Abstract: A payload delivery device is an apparatus designed to facilitate the delivery of emergency items to a target location via aerial vehicles. The apparatus includes a base strap, a plurality of holder straps, and a plurality of cargo straps. The base strap serves as the central structure of the apparatus that supports the plurality of holder straps and the plurality of cargo straps. The plurality of holder straps includes several straps designed to retain a parachute and the devices necessary to facilitate the deployment of the parachute. The plurality of holder straps is also designed to facilitate the operation of the parachute while securing the parachute to the base strap. The plurality of cargo straps include several straps that secure the payload to the apparatus. The plurality of cargo straps can also be arranged to accommodate the shape and size of the payload to be delivered using the apparatus.

Abstract: One example implementation provides a method for controlling enclosure interior temperature, including obtaining, from a thermostat, temperature data indicative of interior enclosure temperature; determining, using a controller, that the temperature data indicates that the interior enclosure temperature exceeds a set point; simulating for a heat exchanger, using the controller, loss of alternating current (AC) power supply; and thereafter operating, using the controller, the heat exchanger and an air conditioner above the set point.

Abstract: A payload delivery device is an apparatus designed to facilitate the delivery of emergency items to a target location via aerial vehicles. The apparatus includes a base strap, a plurality of holder straps, and a plurality of cargo straps. The base strap serves as the central structure of the apparatus that supports the plurality of holder straps and the plurality of cargo straps. The plurality of holder straps includes several straps designed to retain a parachute and the devices necessary to facilitate the deployment of the parachute. The plurality of holder straps is also designed to facilitate the operation of the parachute while securing the parachute to the base strap. The plurality of cargo straps include several straps that secure the payload to the apparatus. The plurality of cargo straps can also be arranged to accommodate the shape and size of the payload to be delivered using the apparatus.

Abstract: Embodiments of the methods and compositions provided herein relate to chimeric antigen receptors (CARs) that specifically bind to B7H3. Some embodiments relate to cell-based immunotherapy targeting tumors, such as tumors comprising B7H3+ cells.

Abstract: Provided herein are methods of transducing resting or non-activated T cells using CD4-targeted viral vectors.

Abstract: An intermedullary nail for targeted arthrodesis of the tibiotalar joint. The intramedullary nail may be advanced through a bore extending through the calcaneus, talus, and into the tibia. In an example, a distal end portion of the intramedullary nail is disposed proximal to the subtalar joint. It has been recognized that creation of a bore for introduction of the intramedullary nail does not significantly disrupt the articular surface area of the subtalar joint. Furthermore, locking fasteners used to secure the intramedullary nail may introduced laterally and/or anteriorly to facilitate benefits in relation to patient placement and manipulation during an operation. Furthermore, arthrodesis may be extended to adjacent anatomy through use of extension plates at least partially secured by locking fasteners also engaging the intramedullary nail.

Abstract: A controller device for cooling a sealed enclosure via closed loop cooling includes: a storage device having executable instructions that: access, from a temperature sensor, an ambient temperature value indicative of temperature outside of the enclosure; begin operation of an auxiliary component responsive to the ambient temperature value being within a predetermined range; access, from the temperature sensor, an updated ambient temperature value; begin operation of an air conditioner responsive to determining the updated ambient temperature value is outside of the predetermined range.