Abstract: Embodiments of the methods and compositions provided herein relate to chimeric antigen receptors (CARs) that specifically bind to B7H3. Some embodiments relate to cell-based immunotherapy targeting tumors, such as tumors comprising B7H3+ cells.

Abstract: Provided are polycistronic vectors for co-expression of one or more tolerogenic factors, one or more CARs, and optionally one or more safety switches, as well as compositions comprising the same, cells comprising the same and methods of generating those cells, and methods of using the disclosed vectors, compositions, and cells to treat diseases such as cancer, diabetes, and neurological diseases.

Abstract: Systems for variable angle insertion of surgical fasteners relative to an orthopedic plate with locking of the surgical fastener relative to the plate upon insertion. The systems may include a pivot member secured relative to either the orthopedic plate or the fastener. In either regard, the pivot member may provide locking engagement with the plate to lockingly engage the fastener relative to the plate.

Abstract: A payload delivery device is an apparatus designed to facilitate the delivery of emergency items to a target location via aerial vehicles. The apparatus includes a base strap, a plurality of holder straps, and a plurality of cargo straps. The base strap serves as the central structure of the apparatus that supports the plurality of holder straps and the plurality of cargo straps. The plurality of holder straps includes several straps designed to retain a parachute and the devices necessary to facilitate the deployment of the parachute. The plurality of holder straps is also designed to facilitate the operation of the parachute while securing the parachute to the base strap. The plurality of cargo straps include several straps that secure the payload to the apparatus. The plurality of cargo straps can also be arranged to accommodate the shape and size of the payload to be delivered using the apparatus.

Abstract: One example implementation provides a method for controlling enclosure interior temperature, including obtaining, from a thermostat, temperature data indicative of interior enclosure temperature; determining, using a controller, that the temperature data indicates that the interior enclosure temperature exceeds a set point; simulating for a heat exchanger, using the controller, loss of alternating current (AC) power supply; and thereafter operating, using the controller, the heat exchanger and an air conditioner above the set point.

Abstract: Systems, computer program products, and methods are described herein for generating a graphical user interface including automatic and dynamic notifications. The present disclosure is configured to receive a trigger associated with a user account; identify user account data associated with the user account, wherein the user account data comprises at least one of a historical data or real time data; identify at least one similar user account based on the at least one similar user account comprising at least one similar historical data or similar real time data; generate a dynamic user account notification interface component, wherein the dynamic user account notification interface component comprises user account data; and transmit the dynamic user account notification interface component to a user device associated with the user account.

Abstract: A payload delivery device is an apparatus designed to facilitate the delivery of emergency items to a target location via aerial vehicles. The apparatus includes a base strap, a plurality of holder straps, and a plurality of cargo straps. The base strap serves as the central structure of the apparatus that supports the plurality of holder straps and the plurality of cargo straps. The plurality of holder straps includes several straps designed to retain a parachute and the devices necessary to facilitate the deployment of the parachute. The plurality of holder straps is also designed to facilitate the operation of the parachute while securing the parachute to the base strap. The plurality of cargo straps include several straps that secure the payload to the apparatus. The plurality of cargo straps can also be arranged to accommodate the shape and size of the payload to be delivered using the apparatus.

Abstract: Embodiments of the methods and compositions provided herein relate to chimeric antigen receptors (CARs) that specifically bind to B7H3. Some embodiments relate to cell-based immunotherapy targeting tumors, such as tumors comprising B7H3+ cells.

Abstract: Provided herein are methods of transducing resting or non-activated T cells using CD4-targeted viral vectors.

Abstract: An intermedullary nail for targeted arthrodesis of the tibiotalar joint. The intramedullary nail may be advanced through a bore extending through the calcaneus, talus, and into the tibia. In an example, a distal end portion of the intramedullary nail is disposed proximal to the subtalar joint. It has been recognized that creation of a bore for introduction of the intramedullary nail does not significantly disrupt the articular surface area of the subtalar joint. Furthermore, locking fasteners used to secure the intramedullary nail may introduced laterally and/or anteriorly to facilitate benefits in relation to patient placement and manipulation during an operation. Furthermore, arthrodesis may be extended to adjacent anatomy through use of extension plates at least partially secured by locking fasteners also engaging the intramedullary nail.

Abstract: A controller device for cooling a sealed enclosure via closed loop cooling includes: a storage device having executable instructions that: access, from a temperature sensor, an ambient temperature value indicative of temperature outside of the enclosure; begin operation of an auxiliary component responsive to the ambient temperature value being within a predetermined range; access, from the temperature sensor, an updated ambient temperature value; begin operation of an air conditioner responsive to determining the updated ambient temperature value is outside of the predetermined range.

Abstract: A biodegradable polymeric composition for food contact applications is disclosed. This polymeric composition includes at least (1) from about 5 weight percent to about 95 weight percent poly(hydroxyalkanoates); (2) from about 5 weight percent to about 95 weight percent of at least one biodegradable polymer selected from the group consisting of poly(butylene succinate), poly(butylene succinate-co-adipate), poly(butylene adipate-co-terephthalate, poly(caprolactone), poly(lactic acid), cellulose esters (such as cellulose acetate) thermoplastic starch, and mixtures thereof; and (3) from about 0.1 weight percent to about 5 weight percent of a nucleating agent.

Abstract: Systems for variable angle insertion of surgical fasteners relative to an orthopedic plate with locking of the surgical fastener relative to the plate upon insertion. The systems may include a pivot member secured relative to either the orthopedic plate or the fastener. In either regard, the pivot member may provide locking engagement with the plate to lockingly engage the fastener relative to the plate.

Abstract: Activity-inducible fusion proteins whose activity is post-translationally regulated utilizing a hsp90 binding domain and a drug molecule are described. In the absence of the drug molecule, the activity-inducible fusion proteins are inactivated but can be activated by a relevant physiological parameter in the presence of the drug molecule. Examples of the activity-inducible fusion proteins include chimeric antigen receptors (CAR) wherein the relevant physiological parameter is antigen binding.

Abstract: An intermedullary nail for targeted arthrodesis of the tibiotalar joint. The intramedullary nail may be advanced through a bore extending through the calcaneus, talus, and into the tibia. In an example, a distal end portion of the intramedullary nail is disposed proximal to the subtalar joint. It has been recognized that creation of a bore for introduction of the intramedullary nail does not significantly disrupt the articular surface area of the subtalar joint. Furthermore, locking fasteners used to secure the intramedullary nail may introduced laterally and/or anteriorly to facilitate benefits in relation to patient placement and manipulation during an operation. Furthermore, arthrodesis may be extended to adjacent anatomy through use of extension plates at least partially secured by locking fasteners also engaging the intramedullary nail.

Abstract: A biodegradable label and a method for making the label. The biodegradable label includes from about 40 to about 99 weight percent of a polymer derived from random monomeric repeating units having a structure of wherein R1 is selected from the group consisting of CH3 and a C3 to C19 alkyl group. The monomeric units having R1?CH3 is about 75 to about 99 mol percent of the polymer. A resin adapted for forming the label is also disclosed.

Abstract: A biodegradable container closure and a method for making the container closure. The biodegradable container closure includes from about 40 to about 99 weight percent of a polymer derived from random monomeric repeating units having a structure of wherein R1 is selected from the group consisting of CH3 and a C3 to C19 alkyl group. The monomeric units having R1?CH3 is about 75 to about 99 mol percent of the polymer. A resin adapted for forming the closure is also disclosed.

Abstract: Activity-inducible fusion proteins whose activity is post-translationally regulated utilizing a hsp90 binding domain and a drug molecule are described. In the absence of the drug molecule, the activity-inducible fusion proteins are inactivated but can be activated by a relevant physiological parameter in the presence of the drug molecule. Examples of the activity-inducible fusion proteins include chimeric antigen receptors (CAR) wherein the relevant physiological parameter is antigen binding.