Abstract: 1. A capsule device (100) suitable for swallowing into a lumen of a gastrointestinal tract of a patient and for intestinal delivery of a therapeutic substance from the capsule device, wherein the capsule device (100) comprises: a) a housing portion (110, 115, 120), b) an activation element (130) movable relative to the housing portion from an expanded pre-delivery configuration into a non-expanded delivery configuration, c) a therapeutic substance comprised in a reservoir (A), and d) a delivery assembly comprising an actuator (140) comprising a potential energy source and a delivery outlet (190). The activation element (130) is movable by intestinal wall peristaltic contraction from the ex-panded pre-delivery configuration into the non-expanded delivery configuration to cause the actuator (140) to deliver the therapeutic substance through the delivery outlet (190).

Abstract: A capsule device (10) suitable for swallowing into a lumen of an intestinal tract of a patient comprises a housing section (12), a delivery outlet (20) for jet injection by a delivery assembly (22), an expansion assembly (26) and an expansion control mechanism (30). The expansion section (28) is arranged laterally opposite to and physically separated from the delivery outlet (20). An expansion section (28) of the expansion assembly (26) is laterally expandable from a non-expanded configuration to an expanded configuration for positioning the delivery outlet (20) against the lumen wall (14). The expansion control mechanism (30) is configured to activate the expansion assembly (26) under a predetermined condition to permit change of the expansion section (28) from the non-expanded configuration to the expanded configuration.