Patents by Inventor Adam K. Glaser
Adam K. Glaser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250231388Abstract: Apparatuses, systems, and methods for modular sample holders. The microscope may direct illumination light along an illumination path towards a sample and collect light from the sample along a collection path. Light along the illumination path may pass through an immersion fluid and the material of the sample holder to reach the sample. Light along collection path may pass through the material of the sample holder and the immersion fluid. The sample holder may have a first optical surface along the illumination path which is generally perpendicular to an optical axis of the illumination path. The sample holder may have a second optical surface along the collection path which is generally perpendicular to an optical axis of the collection path. The sample holder may be modular. The sample holder may contain the sample in an enclosed channel.Type: ApplicationFiled: September 5, 2024Publication date: July 17, 2025Inventors: Adam K. Glaser, Jonathan T.C. Liu, Nicholas Reder
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Publication number: 20240418653Abstract: Embodiments of the disclosure are drawn to apparatuses, systems, and methods for 3D microdissection of samples. A microdissection system includes an imaging system and an extraction system. The imaging system may include a fluorescent microscope, and collects a 3D image of a sample. A region of interest is identified in the sample based on the 3D image. The extraction system extracts the identified region of interest. The imaging, identification, and/or extraction may be manual, automated, or a combination thereof.Type: ApplicationFiled: August 28, 2024Publication date: December 19, 2024Inventors: Adam K. Glaser, Jonathan T.C. LIU, Nicholas P. Reder
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Patent number: 11885946Abstract: Embodiments disclosed herein directed to multi-direction digital light sheet microscopy (mDSLM). In mDSLM a sample may be illuminated with an illumination sheet which has a first angular diversity along a first axis and a second angular diversity along a second axis which is orthogonal to the first axis. An mDSLM system includes beam shaping optics which may passively reshape light into the illumination sheet. In some embodiments, scanning optics may be used to scan the illumination sheet with respect to the sample. In some embodiments, a confocal aperture may be used to limit out of focus light which reaches a detector of the mDSLM system.Type: GrantFiled: January 25, 2019Date of Patent: January 30, 2024Assignee: University of WashingtonInventors: Adam K. Glaser, Jonathan T. C. Liu
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Publication number: 20230341669Abstract: Apparatuses, systems, and methods for an open-top light-sheet (OTLS) microscope which includes an illumination objective and a collection objective which have optical axes which are non-orthogonal to each other. The optical axis of the collection objective may be orthogonal to a plane of the sample holder. The illumination and collection objective may be located below the sample holder. The OTLS microscope may optionally include a second collection objective which has an optical axis orthogonal to the optical axis of the illumination objective. The illumination objective may be an air objective, and the collection objective may be an immersion objective.Type: ApplicationFiled: March 23, 2023Publication date: October 26, 2023Inventors: Adam K. Glaser, Jonathan T.C. Liu
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Patent number: 11644656Abstract: Apparatuses, systems, and methods for an open-top light-sheet (OTLS) microscope which includes an illumination objective and a collection objective which have optical axes which are non-orthogonal to each other. The optical axis of the collection objective may be orthogonal to a plane of the sample holder. The illumination and collection objective may be located below the sample holder. The OTLS microscope may optionally include a second collection objective which has an optical axis orthogonal to the optical axis of the illumination objective. The illumination objective may be an air objective, and the collection objective may be an immersion objective.Type: GrantFiled: May 5, 2022Date of Patent: May 9, 2023Assignee: University of WashingtonInventors: Adam K. Glaser, Jonathan T. C. Liu
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Publication number: 20220326502Abstract: Apparatuses, systems, and methods for solid immersion meniscus lenses (STMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices.Type: ApplicationFiled: February 24, 2022Publication date: October 13, 2022Applicant: University of WashingtonInventors: Jonathan T.C. Liu, Lindsey A. Barner, Adam K. Glaser
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Publication number: 20220260821Abstract: Apparatuses, systems, and methods for an open-top light-sheet (OTLS) microscope which includes an illumination objective and a collection objective which have optical axes which are non-orthogonal to each other. The optical axis of the collection objective may be orthogonal to a plane of the sample holder. The illumination and collection objective may be located below the sample holder. The OTLS microscope may optionally include a second collection objective which has an optical axis orthogonal to the optical axis of the illumination objective. The illumination objective may be an air objective, and the collection objective may be an immersion objective.Type: ApplicationFiled: May 5, 2022Publication date: August 18, 2022Applicant: University of WashingtonInventors: Adam K. Glaser, Jonathan T.C. Liu
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Patent number: 11287633Abstract: Apparatuses, systems, and methods for solid immersion meniscus lenses (SIMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices.Type: GrantFiled: June 23, 2021Date of Patent: March 29, 2022Assignee: University of WashingtonInventors: Jonathan T. C. Liu, Lindsey A. Barner, Adam K. Glaser
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Publication number: 20220050280Abstract: Apparatuses, systems, and methods for modular sample holders. The microscope may direct illumination light along an illumination path towards a sample and collect light from the sample along a collection path. Light along the illumination path may pass through an immersion fluid and the material of the sample holder to reach the sample. Light along collection path may pass through the material of the sample holder and the immersion fluid. The sample holder may have a first optical surface along the illumination path which is generally perpendicular to an optical axis of the illumination path. The sample holder may have a second optical surface along the collection path which is generally perpendicular to an optical axis of the collection path. The sample holder may be modular. The sample holder may contain the sample in an enclosed channel.Type: ApplicationFiled: February 12, 2020Publication date: February 17, 2022Applicant: University of WashingtonInventors: Adam K. Glaser, Jonathan T.C. Liu, Nicholas Reder
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Publication number: 20210325656Abstract: Apparatuses, systems, and methods for solid immersion meniscus lenses (SIMlenses). An optical system may include a sample holder with a first side which supports a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices.Type: ApplicationFiled: June 23, 2021Publication date: October 21, 2021Applicant: University of WashingtonInventors: Jonathan T.C. Liu, Lindsey A. Barner, Adam K. Glaser
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Patent number: 10940332Abstract: A monitor for pulsed high energy radiation therapy using a radiation beam passing through a treatment zone, the radiation of 0.2 MEV or greater; has a camera for imaging Cherenkov light from the treatment zone; apparatus for preventing interference by room lighting, the camera synchronized to pulses of the radiation beam; and an image processor adapted to determine extent of the beam area on the patient skin from the images. Additionally an image processor determines cumulative skin dose in the treatment zone from the images. In embodiments, the processor uses a three-dimensional model of a subject to determine mapping of image intensity in images of Cherenkov light to radiation intensity in skin, applies the mapping to images of Cherenkov light to verify skin dose delivered, and accumulates skin dose by summing the maps of skin dose.Type: GrantFiled: May 20, 2016Date of Patent: March 9, 2021Assignee: THE TRUSTEES OF DARTMOUTH COLLEGEInventors: Rongxiao Zhang, Brian William Pogue, Adam K. Glaser, David J. Gladstone, Lesley A. Jarvis, Jacqueline M. Andreozzi, Shudong Jiang, Scott Christian Davis, Johan Jakob Axelsson
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Publication number: 20210033838Abstract: Embodiments disclosed herein directed to multi-direction digital light sheet microscopy (mDSLM). In mDSLM a sample may be illuminated with an illumination sheet which has a first angular diversity along a first axis and a second angular diversity along a second axis which is orthogonal to the first axis. An mDSLM system includes beam shaping optics which may passively reshape light into the illumination sheet. In some embodiments, scanning optics may be used to scan the illumination sheet with respect to the sample. In some embodiments, a confocal aperture may be used to limit out of focus light which reaches a detector of the mDSLM system.Type: ApplicationFiled: January 25, 2019Publication date: February 4, 2021Applicant: University of WashingtonInventors: Adam K. Glaser, Jonathan T.C. Liu
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Publication number: 20160263402Abstract: A monitor for pulsed high energy radiation therapy using a radiation beam passing through a treatment zone, the radiation of 0.2 MEV or greater; has a camera for imaging Cherenkov light from the treatment zone; apparatus for preventing interference by room lighting, the camera synchronized to pulses of the radiation beam; and an image processor adapted to determine extent of the beam area on the patient skin from the images. Additionally an image processor determines cumulative skin dose in the treatment zone from the images. In embodiments, the processor uses a three-dimensional model of a subject to determine mapping of image intensity in images of Cherenkov light to radiation intensity in skin, applies the mapping to images of Cherenkov light to verify skin dose delivered, and accumulates skin dose by summing the maps of skin dose.Type: ApplicationFiled: May 20, 2016Publication date: September 15, 2016Inventors: Rongxiao Zhang, Brian William Pogue, Adam K. Glaser, David J. Gladstone, Lesley A. Jarvis, Jacqueline M. Andreozzi, Shudong Jiang, Scott Christian Davis, Johan Jakob Axelsson