Abstract: The present invention provides a compound which is a polyunsaturated fatty acid (PUFA) derivative of formula (I), or a pharmaceutically acceptable salt, or solvate thereof, for use in treating various skin disorders.

Abstract: There is provided a process for purifying a fatty acid, which process comprises reacting a fatty acid with a lithium salt in a first solution and under conditions to allow formation of a precipitate of a lithium salt of the fatty acid; isolating the precipitate; dissolving the precipitate in a second solution followed by separation of the organic and aqueous layers so formed; and evaporating the organic layer to isolate the purified fatty acid. There is also provided a process for increasing the length of a fatty acid, and the use of a lithium salt to purify a fatty acid.

Abstract: The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous alcohol, wherein the apparatus has a plurality of zones comprising at least a first zone and second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the PUFA product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the PUFA product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said PUFA product bein

Abstract: The present invention provides a compound which is a polyunsaturated fatty acid (PUFA) derivative of formula (I), or a pharmaceutically acceptable salt, or solvate thereof, for use in treating various skin disorders.

Abstract: The present invention provides a compound which is a polyunsaturated fatty acid (PUFA) derivative of formula (I), or a pharmaceutically acceptable salt, or solvate thereof, for use in treating various skin disorders.

Abstract: The present invention provides use of compounds which are polyunsaturated fatty acid (PUFA) derivatives of formula (I), in the form of racemates, stereoisomers or mixtures of stereoisomers, or pharmaceutically acceptable salts, or solvates thereof, wherein -AIk- is —(CH2)4—CH(OR2)-[trans]CH?CH-[cis]CH?CH—, —(CH2)4-[cis]CH?CH-[trans]CH?CH—CH(OR2)—, —CH(OR2)-[trans]CH?CH-[cis]CH?CH—CH2-[cis]CH?CH—(CH2)3—, —(CH2)3—CH(OR2)-[trans]CH?CH-[cis]CH?CH—CH2-[cis]CH?CH—, or —(CH2)3-[cis]CH?CH—CH2-[cis]CH?CH-[trans]CH?CH—CH(OR2)—; R1 is a hydrogen atom; or R1 is a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C6-C10 aryl, 5- to 10-membered heteroaryl, C3-C7 carbocyclyl or 5- to 10-membered heterocyclyl group; or R1 is a group of formula —CH2—CH(OR3)—CH2—(OR4), wherein R3 and R4 are each independently hydrogen atoms or —(C?O)—R6, wherein R6 is an aliphatic group having from 3 to 29 carbon atoms; or R1 is a group of formula —(CH2OCH2)mOH, wherein m is an integer of from 1 to 200; or R1 is a drug moiety; each R2 is the-same or