Patents by Inventor Adam L. Borne

Adam L. Borne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12366579
    Abstract: Sulfonyl-triazole compounds and related sulfonyl-heterocycle compounds are described. The compounds can be used to identify reactive nucleophilic amino acid residues, such as reactive tyrosines and reactive lysines, in proteins and to modify the activity of proteins with reactive nucleophilic amino acid residues via the formation of protein adducts comprising a fragment of the compounds. Methods are also described for screening the compounds to identify ligands of proteins comprising a reactive lysine or a reactive tyrosine.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: July 22, 2025
    Assignee: University of Virginia Patent Foundation
    Inventors: Ku-Lung Hsu, Heung Sik Hahm, Emmanuel K. Toroitich, Jeffrey W. Brulet, Adam L. Borne, Adam Herman Libby, Kun Yuan
  • Publication number: 20220214355
    Abstract: Sulfonyl-triazole compounds and related sulfonyl-heterocycle compounds are described. The compounds can be used to identify reactive nucleophilic amino acid residues, such as reactive tyrosines and reactive lysines, in proteins and to modify the activity of proteins with reactive nucleophilic amino acid residues via the formation of protein adducts comprising a fragment of the compounds. Methods are also described for screening the compounds to identify ligands of proteins comprising a reactive lysine or a reactive tyrosine.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 7, 2022
    Applicant: University of Virginia Patent Foundation
    Inventors: Ku-Lung Hsu, Heung Sik Hahm, Emmanuel K. Toroitich, Jeffrey W. Brulet, Adam L. Borne, Adam Herman Libby, Kun Yuan