Patents by Inventor Adam Leon
Adam Leon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11945830Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.Type: GrantFiled: February 24, 2022Date of Patent: April 2, 2024Assignee: Enanta Pharmaceuticals, Inc.Inventors: Adam Szymaniak, Jianming Yu, Kevin McGrath, Xiben Li, Tyler J. Mann, Robert Leon, In Jong Kim, Yat Sun Or, Long Nguyen
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Patent number: 11763397Abstract: A method and system for providing recipient recommendations to a user wishing to share content with a contact is provided. A message having the content along with a first contact is received from the user. Profiles from an entire social graph associated with the user and the first contact are searched to determine a shared attributed among both profiles. The shared attribute is used to search for a second contact to receive the content by searching for the shared attribute in a profile associated with the second contact. When a determination is made that the profile associated with the second contact has the shared attribute, the second contact is suggested as a recipient of the content.Type: GrantFiled: December 31, 2020Date of Patent: September 19, 2023Assignee: Microsoft Technology Licensing, LLCInventors: Adam Leon, David Golland
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Publication number: 20220207620Abstract: A method and system for providing recipient recommendations to a user wishing to share content with a contact is provided. A message having the content along with a first contact is received from the user. Profiles from an entire social graph associated with the user and the first contact are searched to determine a shared attributed among both profiles. The shared attribute is used to search for a second contact to receive the content by searching for the shared attribute in a profile associated with the second contact. When a determination is made that the profile associated with the second contact has the shared attribute, the second contact is suggested as a recipient of the content.Type: ApplicationFiled: December 31, 2020Publication date: June 30, 2022Inventors: Adam Leon, David Golland
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Publication number: 20210342038Abstract: Techniques for improving an interactive user interface of a messaging application by dynamically identifying a configurable number of top-ranked targets for a new message from a plurality of possible targets for the new message are disclosed. An interaction with the messaging application is detected. The interaction is determined to be indicative of an intent to identify a target for the new message from the plurality of possible targets for the new message. The identifying of the targets is performed by applying a matching algorithm to the one or more keywords. The matching algorithm blends a ranking of individual connections associated with the member with a ranking of group conversations associated with the member. Responsive to the detection of the interaction, a listing of identifiers associated with the targets is caused to be presented in a search results portion of the user interface.Type: ApplicationFiled: May 4, 2020Publication date: November 4, 2021Inventors: Adam Leon, Monique Yin, David Golland, Felix Giguere Villegas
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Publication number: 20210230234Abstract: The present disclosure relates to the use of a maltose dependent degron to control stability of a protein of interest fused thereto at the post-translational level. The present disclosure also relates to the use of a maltose dependent degron in combination with a maltose-responsive promoter to control gene expression at the transcriptional level and to control protein stability at the post-translational level. The present disclosure also relates to the use of a stabilization construct that couples expression of a cell-growth-affecting protein with the production of non-catabolic compounds. The present disclosure further relates to the use of a synthetic maltose-responsive promoter. The present disclosure further provides compositions and methods for using a maltose dependent degron, a maltose-responsive promoter, and a stabilization construct, either alone or in various combinations, for the production of non-catabolic compounds in genetically modified host cells.Type: ApplicationFiled: April 2, 2021Publication date: July 29, 2021Inventors: Penelope R. CHUA, Hanxiao JIANG, Adam Leon MEADOWS
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Patent number: 10988513Abstract: The present disclosure relates to the use of a maltose dependent degron to control stability of a protein of interest fused thereto at the post-translational level. The present disclosure also relates to the use of a maltose dependent degron in combination with a maltose-responsive promoter to control gene expression at the transcriptional level and to control protein stability at the post-translational level. The present disclosure also relates to the use of a stabilization construct that couples expression of a cell-growth-affecting protein with the production of non-catabolic compounds. The present disclosure further relates to the use of a synthetic maltose-responsive promoter. The present disclosure further provides compositions and methods for using a maltose dependent degron, a maltose-responsive promoter, and a stabilization construct, either alone or in various combinations, for the production of non-catabolic compounds in genetically modified host cells.Type: GrantFiled: June 24, 2016Date of Patent: April 27, 2021Assignees: AMYRIS, INC., TOTAL MARKETING SERVICESInventors: Penelope R. Chua, Hanxiao Jiang, Adam Leon Meadows
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Publication number: 20200399326Abstract: The present disclosure relates to the use of a maltose dependent degron to control stability of a protein of interest fused thereto at the post-translational level. The present disclosure also relates to the use of a maltose dependent degron in combination with a maltose-responsive promoter to control gene expression at the transcriptional level and to control protein stability at the post-translational level. The present disclosure also relates to the use of a stabilization construct that couples expression of a cell-growth-affecting protein with the production of non-catabolic compounds. The present disclosure further relates to the use of a synthetic maltose-responsive promoter. The present disclosure further provides compositions and methods for using a maltose dependent degron, a maltose-responsive promoter, and a stabilization construct, either alone or in various combinations, for the production of non-catabolic compounds in genetically modified host cells.Type: ApplicationFiled: September 4, 2020Publication date: December 24, 2020Inventors: Penelope R. CHUA, Hanxiao JIANG, Adam Leon MEADOWS
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Patent number: 10808015Abstract: The present disclosure relates to the use of a maltose dependent degron to control stability of a protein of interest fused thereto at the post-translational level. The present disclosure also relates to the use of a maltose dependent degron in combination with a maltose-responsive promoter to control gene expression at the transcriptional level and to control protein stability at the post-translational level. The present disclosure also relates to the use of a stabilization construct that couples expression of a cell-growth-affecting protein with the production of non-catabolic compounds. The present disclosure further relates to the use of a synthetic maltose-responsive promoter. The present disclosure further provides compositions and methods for using a maltose dependent degron, a maltose-responsive promoter, and a stabilization construct, either alone or in various combinations, for the production of non-catabolic compounds in genetically modified host cells.Type: GrantFiled: June 24, 2016Date of Patent: October 20, 2020Assignee: AMYRIS, INC.Inventors: Penelope R. Chua, Hanxiao Jiang, Adam Leon Meadows
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Publication number: 20200201488Abstract: In some embodiments, a computer system detects that a digital content item associated with a second user is to be displayed in a data feed of a first user, determines that the first user has a connection with the second user that satisfies a connection criteria that the connection be of at least a predetermined degree, causes a first selectable user interface element to be displayed in association with the digital content item in the data feed of the first user based on the determining that the first user has the connection with the second user that satisfies the connection criteria, and causes a message creation element to be displayed in response to the a user selection of the first selectable user interface element, with the message creation element comprising an address field that is auto-populated to identify the second user as the only recipient of a message.Type: ApplicationFiled: December 21, 2018Publication date: June 25, 2020Inventors: Shu-Yi Zhou, Yizhou Pan, Adam Leon, Yitian Xu, Cameron Askew
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Patent number: 10680978Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for generating recommended responses based on historical data. A messaging system receives a message as part of a communication session between a first client device and a second client device. The message originated from the first client device. The messaging system determines, using the message as input in a statistical model, a set of candidate responses for replying to the message. The statistical model was generated based on historical message data transmitted as part of previous communication sessions between a plurality of client devices. The set of candidate responses is a subset of a set of available candidate responses. The messaging system determines, based on a set of candidate selection rules, a subset of the candidate responses yielding a set of recommended responses to the message, and causes the set of recommended responses to be presented on the second client device.Type: GrantFiled: January 31, 2018Date of Patent: June 9, 2020Assignee: Microsoft Technology Licensing, LLCInventors: Adam Leon, Nandeesh Channabasappa Rajashekar, Nimesh Chakravarthi, Jeffrey William Pasternack, Birjodh Tiwana, Arpit Dhariwal, Bing Zhao
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Publication number: 20190124019Abstract: Disclosed are systems, methods, and non-transitory computer-readable media for generating recommended responses based on historical data. A messaging system receives a message as part of a communication session between a first client device and a second client device. The message originated from the first client device. The messaging system determines, using the message as input in a statistical model, a set of candidate responses for replying to the message. The statistical model was generated based on historical message data transmitted as part of previous communication sessions between a plurality of client devices. The set of candidate responses is a subset of a set of available candidate responses. The messaging system determines, based on a set of candidate selection rules, a subset of the candidate responses yielding a set of recommended responses to the message, and causes the set of recommended responses to be presented on the second client device.Type: ApplicationFiled: January 31, 2018Publication date: April 25, 2019Inventors: Adam Leon, Nandeesh Channabasappa Rajashekar, Nimesh Chakravarthi, Jeffrey William Pasternack, Birjodh Tiwana, Arpit Dhariwal, Bing Zhao
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Publication number: 20180186841Abstract: The present disclosure relates to the use of a maltose dependent degron to control stability of a protein of interest fused thereto at the post-translational level. The present disclosure also relates to the use of a maltose dependent degron in combination with a maltose-responsive promoter to control gene expression at the transcriptional level and to control protein stability at the post-translational level. The present disclosure also relates to the use of a stabilization construct that couples expression of a cell-growth-affecting protein with the production of non-catabolic compounds. The present disclosure further relates to the use of a synthetic maltose-responsive promoter. The present disclosure further provides compositions and methods for using a maltose dependent degron, a maltose-responsive promoter, and a stabilization construct, either alone or in various combinations, for the production of non-catabolic compounds in genetically modified host cells.Type: ApplicationFiled: June 24, 2016Publication date: July 5, 2018Inventors: Penelope R. CHUA, Hanxiao JIANG, Adam Leon MEADOWS
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Publication number: 20180171341Abstract: The present disclosure relates to the use of a maltose dependent degron to control stability of a protein of interest fused thereto at the post-translational level. The present disclosure also relates to the use of a maltose dependent degron in combination with a maltose-responsive promoter to control gene expression at the transcriptional level and to control protein stability at the post-translational level. The present disclosure also relates to the use of a stabilization construct that couples expression of a cell-growth-affecting protein with the production of non-catabolic compounds. The present disclosure further relates to the use of a synthetic maltose-responsive promoter. The present disclosure further provides compositions and methods for using a maltose dependent degron, a maltose-responsive promoter, and a stabilization construct, either alone or in various combinations, for the production of non-catabolic compounds in genetically modified host cells.Type: ApplicationFiled: June 24, 2016Publication date: June 21, 2018Inventors: Penelope R. CHUA, Hanxiao JIANG, Adam Leon MEADOWS
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Patent number: 9914941Abstract: Provided herein are compositions and methods for the heterologous production of acetyl-CoA-derived isoprenoids in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an acetaldehyde dehydrogenase, acetylating (ADA, E.C. 1.2.1.10) and an MEV pathway comprising an NADH-using HMG-CoA reductase. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an ADA and an MEV pathway comprising an acetoacetyl-CoA synthase. In some embodiments, the genetically modified host cell further comprises one or more heterologous nucleotide sequences encoding a phosphoketolase and a phosphotransacetylase. In some embodiments, the genetically modified host cell further comprises a functional disruption of the native PDH-bypass. The compositions and methods described herein provide an energy-efficient yet redox balanced route for the heterologous production of acetyl-CoA-derived isoprenoids.Type: GrantFiled: September 2, 2014Date of Patent: March 13, 2018Assignee: AMYRIS, INC.Inventors: Timothy Stevens Gardner, Kristy Michelle Hawkins, Adam Leon Meadows, Annie Ening Tsong, Yoseph Tsegaye
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Patent number: 9767536Abstract: A method of providing a medical image of a region of interest (ROI) of a patient, the method comprising: acquiring a time ordered sequence of measurements of radiation used to provide the medical image; generating a Fourier transform of the time ordered sequence or a function thereof; using the Fourier transform to determine which of the frequencies characterize real motion of tissue in the ROI and which characterize noise; generating a corrected Fourier transform that is exclusive of frequencies that characterize noise; and providing a medical image of the ROI using the corrected Fourier transform.Type: GrantFiled: March 12, 2014Date of Patent: September 19, 2017Assignee: Memorial Sloan Kettering Cancer CenterInventor: Adam Leon Kesner
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Patent number: 9410214Abstract: Provided herein are compositions and methods for improved production of acetyl-CoA and acetyl-CoA derived compounds in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding a phosphoketolase (PK), and a functional disruption of an endogenous enzyme that converts acetyl phosphate to acetate. In some embodiments, the host cell further comprises a heterologous nucleotide sequence encoding a phosphotransacetylase (PTA). In some embodiments, the enzyme that converts acetyl phosphate to acetate is a glycerol-1-phosphatase. In some embodiments, the glycerol-1-phosphatase is GPP1/RHR2. In some embodiments, the glycerol-1-phosphatase is GPP2/HOR2. The compositions and methods described herein provide an efficient route for the heterologous production of acetyl-CoA-derived compounds, including but not limited to, isoprenoids, polyketides, and fatty acids.Type: GrantFiled: March 14, 2014Date of Patent: August 9, 2016Assignee: Amyris, Inc.Inventors: Kristy Michelle Hawkins, Tina Tipawan Mahatdejkul-Meadows, Adam Leon Meadows, Lauren Barbara Pickens, Anna Tai, Annie Ening Tsong
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Publication number: 20160019679Abstract: A method of providing a medical image of a region of interest (ROI) of a patient, the method comprising: acquiring a time ordered sequence of measurements of radiation used to provide the medical image; generating a Fourier transform of the time ordered sequence or a function thereof; using the Fourier transform to determine which of the frequencies characterize real motion of tissue in the ROI and which characterize noise; generating a corrected Fourier transform that is exclusive of frequencies that characterize noise; and providing a medical image of the ROI using the corrected Fourier transform.Type: ApplicationFiled: March 12, 2014Publication date: January 21, 2016Inventor: Adam Leon KESNER
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Publication number: 20150093797Abstract: Provided herein are compositions and methods for the heterologous production of acetyl-CoA-derived isoprenoids in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an acetaldehyde dehydrogenase, acetylating (ADA, E.C. 1.2.1.10) and an MEV pathway comprising an NADH-using HMG-CoA reductase. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an ADA and an MEV pathway comprising an acetoacetyl-CoA synthase. In some embodiments, the genetically modified host cell further comprises one or more heterologous nucleotide sequences encoding a phosphoketolase and a phosphotransacetylase. In some embodiments, the genetically modified host cell further comprises a functional disruption of the native PDH-bypass. The compositions and methods described herein provide an energy-efficient yet redox balanced route for the heterologous production of acetyl-CoA-derived isoprenoids.Type: ApplicationFiled: September 2, 2014Publication date: April 2, 2015Applicant: AMYRIS, INC.Inventors: Timothy Stevens GARDNER, Kristy Michelle HAWKINS, Adam Leon MEADOWS, Annie Ening TSONG, Yoseph TSEGAYE
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Patent number: 8859261Abstract: Provided herein are compositions and methods for the heterologous production of acetyl-CoA-derived isoprenoids in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an acetaldehyde dehydrogenase, acetylating (ADA, E.C. 1.2.1.10) and an MEV pathway comprising an NADH-using HMG-CoA reductase. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding an ADA and an MEV pathway comprising an acetoacetyl-CoA synthase. In some embodiments, the genetically modified host cell further comprises one or more heterologous nucleotide sequences encoding a phosphoketolase and a phosphotransacetylase. In some embodiments, the genetically modified host cell further comprises a functional disruption of the native PDH-bypass. The compositions and methods described herein provide an energy-efficient yet redox balanced route for the heterologous production of acetyl-CoA-derived isoprenoids.Type: GrantFiled: October 24, 2013Date of Patent: October 14, 2014Assignee: Amyris, Inc.Inventors: Timothy Stevens Gardner, Kristy Michelle Hawkins, Adam Leon Meadows, Annie Ening Tsong, Yoseph Tsegaye
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Publication number: 20140273144Abstract: Provided herein are compositions and methods for improved production of acetyl-CoA and acetyl-CoA derived compounds in a host cell. In some embodiments, the host cell is genetically modified to comprise a heterologous nucleotide sequence encoding a phosphoketolase (PK), and a functional disruption of an endogenous enzyme that converts acetyl phosphate to acetate. In some embodiments, the host cell further comprises a heterologous nucleotide sequence encoding a phosphotransacetylase (PTA). In some embodiments, the enzyme that converts acetyl phosphate to acetate is a glycerol-1-phosphatase. In some embodiments, the glycerol-1-phosphatase is GPP1/RHR2. In some embodiments, the glycerol-1-phosphatase is GPP2/HOR2. The compositions and methods described herein provide an efficient route for the heterologous production of acetyl-CoA-derived compounds, including but not limited to, isoprenoids, polyketides, and fatty acids.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Inventors: Kristy Michelle Hawkins, Tina Tipawan Mahatdejkul-Meadows, Adam Leon Meadows, Lauren Barbara Pickens, Anna Tai, Annie Ening Tsong