Patents by Inventor Adam LEVINSON
Adam LEVINSON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250199397Abstract: A first location within a mask pattern of a semiconductor circuit layout is determined, based on a feature of the mask pattern that is within a threshold distance of a boundary in the mask pattern. The mask pattern is based on a first mask exposure and a second mask exposure that meet at the boundary. The first location defines where to place a first assistive feature that reduces a sensitivity to lithographic process variations of the feature of the mask pattern. A second location of the mask pattern is also determined. The second location defines where to place a second assistive feature that reduces stray light at the boundary during the first mask exposure and the second mask exposure. The mask pattern is then modified to place the first assistive feature in the first location and the second assistive feature in the second location.Type: ApplicationFiled: December 14, 2023Publication date: June 19, 2025Inventors: Robert Michal Iwanow, Zachary Adam Levinson, Kevin Dean Lucas, James Erwin Burdorf
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Patent number: 11900042Abstract: In some aspects, a mask pattern is accessed. The mask pattern is for use in a lithography process that prints a pattern on a wafer. The mask pattern is applied as input to a deterministic model of the lithography process to predict a characteristic of the printed pattern. The deterministic model is deterministic, but it accounts for local stochastic variations of the characteristic in the printed pattern.Type: GrantFiled: November 9, 2021Date of Patent: February 13, 2024Assignee: Synopsys, Inc.Inventors: Kevin Dean Lucas, Yudhishthir Prasad Kandel, Ulrich Welling, Ulrich Karl Klostermann, Zachary Adam Levinson
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Publication number: 20230365584Abstract: The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for inhibiting kinase activity, and for treating cancer.Type: ApplicationFiled: September 8, 2021Publication date: November 16, 2023Inventors: Xianhai HUANG, Sayan MONDAL, Phani GHANAKOTA, Nicholas BOYLES, Leah FRYE, Adam LEVINSON, Jeremy Robert GREENWOOD, Pieter BOS, Sathesh BHAT, Aleksey GERASYUTO, Haifeng TANG
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Patent number: 11415897Abstract: Calibrating stochastic signals in compact modeling is provided by obtaining data of process variations in producing a resist mask; calibrating a continuous compact model of the resist mask based on the data; evaluating the continuous compact model against a stochastic compact model that is based on the data; choosing a functional description of an edge location distribution for the stochastic compact model; mapping image parameters from the evaluation to edge distribution parameters according to the functional description; determining an edge location range for the stochastic compact model based on scaled measurements from the image parameters; calibrating a threshold for the resist mask and updating parameters of the stochastic compact model to reduce a difference between the data and a modeled Line Edge Roughness (LER) value; and outputting the stochastic compact model.Type: GrantFiled: June 4, 2021Date of Patent: August 16, 2022Assignee: Synopsys, Inc.Inventors: Zachary Adam Levinson, Yudhishthir Prasad Kandel, Ulrich Welling
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Publication number: 20220146945Abstract: In some aspects, a mask pattern is accessed. The mask pattern is for use in a lithography process that prints a pattern on a wafer. The mask pattern is applied as input to a deterministic model of the lithography process to predict a characteristic of the printed pattern. The deterministic model is deterministic, but it accounts for local stochastic variations of the characteristic in the printed pattern.Type: ApplicationFiled: November 9, 2021Publication date: May 12, 2022Inventors: Kevin Dean Lucas, Yudhishthir Prasad Kandel, Ulrich Welling, Ulrich Karl Klostermann, Zachary Adam Levinson
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Publication number: 20210382394Abstract: Calibrating stochastic signals in compact modeling is provided by obtaining data of process variations in producing a resist mask; calibrating a continuous compact model of the resist mask based on the data; evaluating the continuous compact model against a stochastic compact model that is based on the data; choosing a functional description of an edge location distribution for the stochastic compact model; mapping image parameters from the evaluation to edge distribution parameters according to the functional description; determining an edge location range for the stochastic compact model based on scaled measurements from the image parameters; calibrating a threshold for the resist mask and updating parameters of the stochastic compact model to reduce a difference between the data and a modeled Line Edge Roughness (LER) value; and outputting the stochastic compact model.Type: ApplicationFiled: June 4, 2021Publication date: December 9, 2021Inventors: Zachary Adam LEVINSON, Yudhishthir Prasad KANDEL, Ulrich WELLING
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Patent number: 10184907Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.Type: GrantFiled: October 8, 2015Date of Patent: January 22, 2019Assignee: T2 Biosystems, Inc.Inventors: Thomas Jay Lowery, Jr., James Joseph Koziarz, Douglas Adam Levinson, David A. Berry, Tuan A. Elstrom, Sonia Kumar, Mark John Audeh
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Publication number: 20160033494Abstract: Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs of nanoparticle reagents and responsive polymer coated magnetic nanoparticles. Additionally provided are methods of use of nanoparticle reagents and responsive polymer coated magnetic nanoparticles for the detection of a stimulus or an analyte with NMR detectors.Type: ApplicationFiled: October 8, 2015Publication date: February 4, 2016Inventors: Thomas Jay LOWERY, JR., James Joseph KOZIARZ, Douglas Adam LEVINSON, David A. BERRY, Tuan A. ELSTROM, Sonia KUMAR, Mark John AUDEH
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Publication number: 20120171204Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders.Type: ApplicationFiled: June 23, 2011Publication date: July 5, 2012Applicant: Millennium Pharmaceuticals, Inc.Inventors: Douglas Adam Levinson, Clare M. Lloyd, Sean A. McCarthy
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Publication number: 20110123548Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders.Type: ApplicationFiled: March 23, 2010Publication date: May 26, 2011Applicant: Millennium Pharmaceuticals, Inc.Inventors: Douglas Adam Levinson, Clare M. Lloyd, Sean A. McCarthy
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Publication number: 20090041752Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders.Type: ApplicationFiled: July 31, 2007Publication date: February 12, 2009Inventors: Douglas Adam Levinson, Clare M. Lloyd, Sean A. McCarthy
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Patent number: 7172750Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders.Type: GrantFiled: September 20, 2002Date of Patent: February 6, 2007Assignee: Millennium Pharmaceuticals, Inc.Inventor: Douglas Adam Levinson
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Publication number: 20030158399Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders.Type: ApplicationFiled: September 20, 2002Publication date: August 21, 2003Applicant: Millennium Pharmaceuticals, Inc.Inventor: Douglas Adam Levinson
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Patent number: 6562343Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders.Type: GrantFiled: December 15, 1999Date of Patent: May 13, 2003Assignee: Millennium Pharmaceuticals, Inc.Inventor: Douglas Adam Levinson
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Publication number: 20030069196Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders.Type: ApplicationFiled: December 4, 2001Publication date: April 10, 2003Applicant: Millennium Pharmaceuticals, Inc.Inventors: Douglas Adam Levinson, Clare M. Lloyd, Sean A. McCarthy
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Patent number: 6455685Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders.Type: GrantFiled: February 27, 1998Date of Patent: September 24, 2002Assignee: Millennium Pharmaceuticals, Inc.Inventor: Douglas Adam Levinson
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Publication number: 20020115140Abstract: The present invention relates, first, to the identification of novel nucleic acid molecules, termed RATH genes and RATH gene products encoded by such nucleic acid molecules, or degenerate variants thereof, that participate in the regulation, control and/or modulation of G-protein-mediated signal transduction involved in T cell activation, including, but not limited to T helper (TH) cell and TH cell subpopulation activation. Specifically, the nucleic acid molecules of the present invention include the genes corresponding to the mammalian RATH genes, including the RATH1.1 genes. Sequence analysis indicates that the RATH genes are novel genes belonging to the RGS (“regulator of G-protein signalling”) gene family, a gene family which encodes gene products involved in G-protein-mediated signal transduction.Type: ApplicationFiled: June 4, 2001Publication date: August 22, 2002Applicant: Millennium Pharmaceuticals, Inc.Inventors: Douglas Adam Levinson, Carlos J. Gimeno
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Patent number: 6414117Abstract: The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders.Type: GrantFiled: May 12, 1999Date of Patent: July 2, 2002Assignee: Millennium Pharmaceuticals, Inc.Inventor: Douglas Adam Levinson
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Patent number: 6395872Abstract: The invention features a method for identifying a cDNA nucleic acid encoding a mammalian protein having a signal sequence, which method includes the following steps: (a) providing library of mammalian cDNA; (b) ligating the library of mammalian cDNA to DNA encoding alkaline phosphatase lacking both a signal sequence and a membrane anchor sequence to form ligated DNA; 8 transforming bacterial cells with the ligated DNA to create a bacterial cell clone library; (d) isolating DNA comprising the mammalian cDNA from at least one clone in the bacterial cell clone library; (e) separately transfecting DNA isolated from clones in step (d) into mammalian cells which do not express alkaline phosphatase to create a mammalian cell clone library wherein each clone in the mammalian cell clone library corresponds to a clone in the bacterial cell clone library; (f) identifying a clone in the mammalian cell clone library which expresses alkaline phosphatase; (g) identifying the clone in the bacterial cell clone library correspType: GrantFiled: November 21, 2001Date of Patent: May 28, 2002Assignee: Millennium Pharmaceuticals, Inc.Inventors: Sean Anthony McCarthy, David Paul Gearing, Douglas Adam Levinson
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Patent number: 6391586Abstract: The invention features a method for identifying a cDNA nucleic acid encoding a mammalian protein having a signal sequence, which method includes the following steps: (a) providing library of mammalian cDNA; (b) ligating the library of mammalian cDNA to DNA encoding alkaline phosphatase lacking both a signal sequence and a membrane anchor sequence to form ligated DNA; (c) transforming bacterial cells with the ligated DNA to create a bacterial cell clone library; (d) isolating DNA comprising the mammalian cDNA from at least one clone in the bacterial cell clone library; (e) separately transfecting DNA isolated from clones in step (d) into mammalian cells which do not express alkaline phosphatase to create a mammalian cell clone library wherein each clone in the mammalian cell clone library corresponds to a clone in the bacterial cell clone library; (f) identifying a clone in the mammalian cell clone library which expresses alkaline phosphatase; (g) identifying the clone in the bacterial cell clone library correType: GrantFiled: November 7, 2000Date of Patent: May 21, 2002Assignee: Millennium Pharmaceuticals, Inc.Inventors: Sean Anthony McCarthy, David Paul Gearing, Douglas Adam Levinson