Abstract: This disclosure relates to methods of managing cancer and tumor growth. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering a combination of chemotherapy agents, wherein a first chemotherapy agent is capable of inhibiting oxidative phosphorylation of pyruvate and a second chemotherapy agent is capable of inhibiting glucose metabolism. In certain embodiments, the first and second chemotherapy agents are administered in combination with an additional chemotherapy agent.

Abstract: This disclosure relates to methods of managing cancer using bis-biguanide compounds, such as alexidine, and pharmaceutical compositions comprising the same. In certain embodiments, this disclosure relates to methods of treating lung cancer comprising administering an effective amount of a bis-biguanide compound to a subject in need thereof. In certain embodiments, this disclosure relates to methods of treating small cell lung cancer comprising administering an effective amount of a bis-biguanide compound to a subject in need thereof. In certain embodiments, the subject is diagnosed with a lung cancer. In certain embodiments, the subject is diagnosed with small cell lung cancer. In certain embodiments, the subject is a human subject.

Abstract: This disclosure relates to method of isolating rare cells, e.g. unique cancer cells. In certain embodiments, the disclosure contemplates methods of identifying unique cells that are in a sample that contains a group of cells that are replicating at unique locations and/or at different rates. In certain embodiments the uniquely isolated and/or identified cells are evaluated for genetic content and/or expression for diagnostic evaluations. In certain embodiments, the disclosure contemplates compositions comprising cells that are derived from methods disclosed herein.

Abstract: Systems and methods of the present invention provide for server(s) assigning section or list item classifications to price list or business data extracted from a website. The server routes each new task verifying the classification to a crowd worker, and the server receives a completed. The server calculates a crowd worker score for each crowd worker based on each worker's quality scores according to the worker's review of the classifications on a worker user interface. The server generates a quality model for predicting a task quality score for the task, according to an error score for the crowd worker. If the error score in the quality model is below a predetermined threshold, the server transmits the completed task to a task reviewer's client for review.

Abstract: Systems and methods of the present invention provide for one or more server computers configured to assign section or list item classifications to price list or business data extracted from a website. The server calculates a crowd worker score for each of a plurality of crowd workers based on each worker's quality and speed scores for tasks reviewing the classifications on a worker user interface. If a crowd worker score for a worker is below a crowd worker quality threshold, each new task is routed to the worker, and the received task, when completed, is routed to a worker whose crowd worker score is above the crowd worker quality threshold for review.

Abstract: Systems and methods of the present invention provide for one or more server computers configured to assign section or list item classifications to price list or business data extracted from a website. The server assigns section or list item classifications to price list or business data extracted from a website. The server calculates a crowd worker score for each of a plurality of crowd workers based on each worker's quality and speed scores for tasks reviewing the classifications on a worker user interface. If a crowd worker score for a worker is below a crowd worker quality threshold, each new task is routed to the worker, and the received task, when completed, is routed to a worker whose crowd worker score is above the crowd worker quality threshold for review.

Abstract: A system and method for document classification are presented. An input document is received (e.g., by at least one server communicatively coupled to a network). A plurality of features are identified in the input document. The plurality of features include sequences of text extracted from the input document. A feature vector of the input document is generated based upon the sequences of text, and the feature vector of the input document is compared to each of a plurality of signature vectors to determine a primary type of the input document. The primary type of the input document is stored into a storage system in communication with the at least one server.

Abstract: A system and method for data classification are presented. A plurality of training tokens are identified by at least one server communicatively coupled to a network. Each training token includes a token retrieved from a content source and a classification of the token. For each training token in the plurality of training tokens, a plurality of n-gram sequences are identified, a plurality of features for the plurality of n-gram sequences are generated, and first training data is generated using the token retrieved from the content source, the plurality of features, and the classification of the token. A first classifier is trained with the first training data, and the first classifier is stored into a storage system in communication with the at least one server.

Abstract: In one form, a vent apparatus includes an inlet frame, a venting member, and a retainer member. The venting member includes a mounting portion, a weakened area or burst slit, and a domed portion. The mounting portion of the venting member is secured between the inlet frame and the retainer member. The retainer member includes vent retainer portions or tab portions that extend over the burst slit. The vent apparatus is configured to burst when an inlet pressure exceeds a predetermined level, where the tab portions will bend away and the venting member will bend past the tab portions to relieve the pressure. The inlet frame is configured to support against a vacuum pressure acting in the opposite direction, with the tab portions generally free from the load caused by the vacuum pressure.

Abstract: A method for performing a market analysis for a first online business is disclosed. Market information for a plurality of online businesses may be collected. A user may request a market analysis for the first online business. Market information for the first online business may also be collected. The marketing information for the plurality of online businesses and the first online business may be canonicalized to make comparisons easier. One or more online businesses in the plurality of online businesses may be selected as being similar to the first online business. The marketing information for the first online business may be compared to the marketing information of the similar one or more online businesses. The results of the comparison may be displayed to the user. The user may request modifications to the first online business. The first online business may be modified and the modified online business may be published.

Abstract: A computer-implemented method, comprises extracting a measure from a content article representing a probability that the article relates to a topic, allocating the article to a group of articles relating to at least one topic on the basis of the measure, using a set of social media objects relating to the article to extract a measure representing a sentiment for the article, and aggregating respective measures for the sentiment of articles in the group to provide an aggregate measure.

Abstract: In one form, a vent apparatus includes an inlet frame, a venting member, and a retainer member. The venting member includes a mounting portion, a weakened area or burst slit, and a domed portion. The mounting portion of the venting member is secured between the inlet frame and the retainer member. The retainer member includes vent retainer portions or tab portions that extend over the burst slit. The vent apparatus is configured to burst when an inlet pressure exceeds a predetermined level, where the tab portions will bend away and the venting member will bend past the tab portions to relieve the pressure. The inlet frame is configured to support against a vacuum pressure acting in the opposite direction, with the tab portions generally free from the load caused by the vacuum pressure.

Abstract: A system and method for automatically determining an amount of review a crowd-sourcing task needs after an initial review has been completed by a processing worker. An evaluation metric is automatically assigned to the work performed by the processing worker to determine the appropriate amount of human review required for a particular task. The evaluation metric may be calculated by accessing and evaluating a plurality of transaction categories related, but not limited to, worker characteristics, document characteristics and processing characteristics. Additionally, the evaluation metric may be used to determine compensation of the processing worker and whether a promotion or demotion is necessary. The system is also capable of balancing individual workloads based upon the evaluation metric.

Abstract: A method for generating a website includes obtaining a seed input associated with an entity. The seed input may include one or more keywords, such as a business name. Obtaining the seed input may include receiving the seed input from the user, or the seed input may be obtained without input from the user. The seed input is used to identify the entity. The method further includes retrieving, using at least one of the seed input and the identification of the entity, content relevant to the entity from one or more data stores. Retrieving the content may include using one or more categories relevant to the entity to identify the content. The website is generated without an input from the entity, and includes at least a portion of the content. Generating the website may include identifying a template having a plurality of content regions for containing the content.

Abstract: A method for generating a website includes obtaining a seed input associated with an entity. The seed input may include one or more keywords, such as a business name. Obtaining the seed input may include receiving the seed input from the user, or the seed input may be obtained without input from the user. The seed input is used to identify the entity. The method further includes retrieving, using at least one of the seed input and the identification of the entity, content relevant to the entity from one or more data stores. Retrieving the content may include using one or more categories relevant to the entity to identify the content. The website is generated without an input from the entity, and includes at least a portion of the content. Generating the website may include identifying a template having a plurality of content regions for containing the content.

Abstract: A method for generating a website includes obtaining a seed input associated with an entity. The seed input may include one or more keywords, such as a business name. Obtaining the seed input may include receiving the seed input from the user, or the seed input may be obtained without input from the user. The seed input is used to identify the entity. The method further includes retrieving, using at least one of the seed input and the identification of the entity, content relevant to the entity from one or more data stores. Retrieving the content may include using one or more categories relevant to the entity to identify the content. The website is generated without an input from the entity, and includes at least a portion of the content. Generating the website may include identifying a template having a plurality of content regions for containing the content.

Abstract: A computer-implemented method, comprises extracting a measure from a content article representing a probability that the article relates to a topic, allocating the article to a group of articles relating to at least one topic on the basis of the measure, using a set of social media objects relating to the article to extract a measure representing a sentiment for the article, and aggregating respective measures for the sentiment of articles in the group to provide an aggregate measure.

Abstract: In one form, a vent apparatus includes an inlet frame, a venting member, and a retainer member. The venting member includes a mounting portion, a weakened area or burst slit, and a domed portion. The mounting portion of the venting member is secured between the inlet frame and the retainer member. The retainer member includes vent retainer portions or tab portions that extend over the burst slit. The vent apparatus is configured to burst when an inlet pressure exceeds a predetermined level, where the tab portions will bend away and the venting member will bend past the tab portions to relieve the pressure. The inlet frame is configured to support against a vacuum pressure acting in the opposite direction, with the tab portions generally free from the load caused by the vacuum pressure.

Abstract: A system and method for prioritizing a fetch order of web pages. The method comprises extracting by a web crawler a set of candidate web pages to be crawled. Each web page in the set of candidate web pages is associated with a website in a computer network. A determination is made to determine if a first website score for the website is in a website score database. The first website score is associated with web pages in the set of candidate web pages if the first website score exists in the website score database. The set of candidate web pages is prioritized with respect to an associated website score for each web page in the candidate set of web pages. Content is retrieved from the set of candidate web. Hyperlinks are extracted from the content. The hyperlinks are stored in a memory unit.

Abstract: A method of determining risk of cancer in a mammal is provided. The method includes analyzing the genomic DNA of the mammal and determining genomic CNV frequency or genomic structural variation. An increase in either CNV frequency or genomic structural variation in comparison to a baseline mean value is indicative of cancer.