Patents by Inventor Adam Maxwell

Adam Maxwell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11884672
    Abstract: The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I): tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: January 30, 2024
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Upul Keerthi Bandarage, Cavan McKeon Bligh, Diane Boucher, Michael John Boyd, Michael Aaron Brodney, Michael Philip Clark, Veronique Damagnez, Lev Tyler Dewey Fanning, Robert Francis Fimognari, Gabrielle Simone Fleming, Kevin James Gagnon, Pedro Manuel Garcia Barrantes, Robert Daniel Giacometti, Simon Giroux, Ronald Lee Grey, Jr., Samantha Guido, Amy Beth Hall, Sarah Carol Hood, Dennis James Hurley, Mac Arthur Johnson, Jr., Peter Jones, Sarathy Kesavan, Mei-Hsiu Lai, Siying Liu, Adam Looker, Brad Maxwell, John Patrick Maxwell, Ales Medek, Philippe Marcel Nuhant, Kirk Alan Overhoff, Setu Roday, Stefanie Roeper, Steven M. Ronkin, Rupa Sawant, Yi Shi, Muna Shrestha, Marisa Sposato, Kathy Stavropoulos, Rebecca Jane Swett, Timothy Lewis Tapley, Qing Tang, Stephen Thomson, Jinwang Xu, Mariam Zaky, Kevin Michael Cottrell
  • Patent number: 11832632
    Abstract: Materials and methods for producing chocolate replicas from individual components are provided herein.
    Type: Grant
    Filed: July 15, 2022
    Date of Patent: December 5, 2023
    Assignee: Voyage Foods, Inc.
    Inventors: Kelsey Tenney, Adam Maxwell, Ethan Charles Beswick, Samuel Ryo, Daniel Assad Saad, Alec Kremonic Lee, Mardonn Carl Chua, Brandon Head
  • Patent number: 11819712
    Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: November 21, 2023
    Assignee: The Regents of the University of Michigan
    Inventors: Charles A. Cain, Adam Maxwell, Zhen Xu, Kuang-Wei Lin
  • Publication number: 20230346451
    Abstract: A system for performing a medical procedure in the intestine of a patient comprises a catheter for insertion into the intestine, a console, and a connector configured to operably attach the catheter to the console. The catheter comprises a shaft including a distal portion, and a functional assembly positioned on the distal portion of the shaft. The functional assembly is configured to receive fluid. The console comprises: a fluid reservoir configured to supply the fluid, a first syringe pump assembly configured to deliver the fluid to the functional assembly, a second syringe pump assembly configured to deliver the fluid to the functional assembly, a fluid heater configured to heat the fluid, and a waste fluid reservoir configured to receive the fluid. The system is configured to treat target tissue of the intestine of the patient. Methods of treating target tissue are also provided.
    Type: Application
    Filed: December 6, 2022
    Publication date: November 2, 2023
    Applicant: Fractyl Health, Inc.
    Inventors: Philip Levin, Jay Caplan, Charles Abele, Greg Dierksen, Andrew Hollett, Thomas Kochem, Adam Jaynes, Jeff Johnson, Jeff Lesica, Lionel Stewart Maclean, Sara Morneau, Bruno Piazzarolo, Len Rosberg, Jonathan Seidmann, R. Maxwell Flaherty, J. Christopher Flaherty
  • Publication number: 20230041133
    Abstract: Materials and methods for producing nut butter replicas from individual components are provided herein.
    Type: Application
    Filed: June 30, 2022
    Publication date: February 9, 2023
    Inventors: Kelsey Tenney, Samuel Ryo, Adam Maxwell, Jillian Angela Jastrzembski, Mardonn Carl Chua, Meaghan Sugrue
  • Publication number: 20230033131
    Abstract: Materials and methods for producing chocolate replicas from individual components are provided herein.
    Type: Application
    Filed: July 15, 2022
    Publication date: February 2, 2023
    Inventors: Kelsey Tenney, Adam Maxwell, Ethan Charles Beswick, Samuel Ryo, Daniel Assad Saad, Alec Kremonic Lee, Mardonn Carl Chua, Brandon Head
  • Publication number: 20210008394
    Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
    Type: Application
    Filed: August 31, 2020
    Publication date: January 14, 2021
    Inventors: Charles A. CAIN, Adam MAXWELL, Zhen XU, Kuang-Wei LIN
  • Patent number: 10780298
    Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: September 22, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Charles A. Cain, Adam Maxwell, Zhen Xu, Kuang-Wei Lin
  • Patent number: 10694974
    Abstract: Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as “boiling histotripsy” (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: June 30, 2020
    Assignees: UNIVERSITY OF WASHINGTON, KONINKLIJKE PHILIPS N.V.
    Inventors: Ari Partanen, Vera Khokhlova, Navid Farr, Donghoon Lee, Wayne Kreider, Tatiana Khokhlova, Adam Maxwell, Yak-Nam Wang, George Schade, Michael Bailey
  • Patent number: 10667831
    Abstract: Disclosed herein are ultrasonic probes and systems incorporating the probes. The probes are configured to produce an ultrasonic therapy exposure that, when applied to a kidney stone, will exert an acoustic radiation force sufficient to produce ultrasonic propulsion. Unlike previous probes configured to produce ultrasonic propulsion, however, the disclosed probes are engineered to produce a relatively large (both wide and long) therapy region effective to produce ultrasonic propulsion. This large therapy region allows the probe to move a plurality of kidney stones (or fragments from lithotripsy) in parallel, thereby providing the user the ability to clear several stones from an area simultaneously. This “broadly focused” probe is, in certain embodiments, combined in a single handheld unit with a typical ultrasound imaging probe to produce real-time imaging. Methods of using the probes and systems to move kidney stones are also provided.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: June 2, 2020
    Assignees: University of Washington, Sonomotion, Inc.
    Inventors: Michael R. Bailey, Bryan Cunitz, Barbrina Dunmire, Adam Maxwell, Oren Levy
  • Publication number: 20200078608
    Abstract: Methods for diagnosing a pathologic tissue membrane, as well as a focused ultrasound apparatus and methods of treatment are disclosed to perform ureterocele puncture noninvasively using focused ultrasound-generated cavitation or boiling bubbles to controllably erode a hole through the tissue. An example ultrasound apparatus may include (a) a therapy transducer having a treatment surface, wherein the therapy transducer comprises a plurality of electrically isolated sections, (b) at least one concave acoustic lens defining a therapy aperture in the treatment surface of the therapy transducer, (c) an imaging aperture defined by either the treatment surface of the therapy transducer or by the at least one concave acoustic lens and (d) an ultrasound imaging probe axially aligned with a central axis of the therapy aperture.
    Type: Application
    Filed: June 20, 2019
    Publication date: March 12, 2020
    Applicants: University of Washington through its Center for Commercialization, The Trustees of Columbia University in the City of New York
    Inventors: Adam Maxwell, Ryan Hsi, Thomas Lendvay, Pasquale Casale, Michael Bailey
  • Patent number: 10350439
    Abstract: Methods for diagnosing a pathologic tissue membrane, as well as a focused ultrasound apparatus and methods of treatment are disclosed to perform ureterocele puncture noninvasively using focused ultrasound-generated cavitation or boiling bubbles to controllably erode a hole through the tissue. An example ultrasound apparatus may include (a) a therapy transducer having a treatment surface, wherein the therapy transducer comprises a plurality of electrically isolated sections, (b) at least one concave acoustic lens defining a therapy aperture in the treatment surface of the therapy transducer, (c) an imaging aperture defined by either the treatment surface of the therapy transducer or by the at least one concave acoustic lens and (d) an ultrasound imaging probe axially aligned with a central axis of the therapy aperture.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: July 16, 2019
    Assignees: University of Washington through its Center for Commercialization, The Trustees of Columbia University in the City of New York
    Inventors: Adam Maxwell, Ryan Hsi, Thomas Lendvay, Pasquale Casale, Michael Bailey
  • Publication number: 20190200656
    Abstract: In one embodiment, a method for creating a food product is provided. The method may include providing a portion of egg base, the egg base including water and egg solids; providing a portion of cations; mixing the water, the egg solids, and the cation portion; and heating the mixture. The cation portion may include at least one of Zinc, Manganese, and Copper cations. In another embodiment, a food product is provided. The food product may include cooked egg; and Sulfur-containing salts of at least one of Zinc, Manganese, and Copper. The food product may contain between 0.25 and 10 mg of metal components of the Sulfur-containing salts per 0.967 g egg white solids and between 0.25 and 10 mg of metal components of the Sulfur-containing salts per 5.35 g egg yolk solids.
    Type: Application
    Filed: December 28, 2018
    Publication date: July 4, 2019
    Inventors: Sharat JONNALAGADDA, Adam MAXWELL, Leslie MORGRET, Niva CHAPA
  • Patent number: 10219815
    Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: March 5, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Adam Maxwell, Zhen Xu, Hitinder S. Gurm, Charles A. Cain
  • Publication number: 20170245874
    Abstract: Disclosed herein are ultrasonic probes and systems incorporating the probes. The probes are configured to produce an ultrasonic therapy exposure that, when applied to a kidney stone, will exert an acoustic radiation force sufficient to produce ultrasonic propulsion. Unlike previous probes configured to produce ultrasonic propulsion, however, the disclosed probes are engineered to produce a relatively large (both wide and long) therapy region effective to produce ultrasonic propulsion. This large therapy region allows the probe to move a plurality of kidney stones (or fragments from lithotripsy) in parallel, thereby providing the user the ability to clear several stones from an area simultaneously. This “broadly focused” probe is, in certain embodiments, combined in a single handheld unit with a typical ultrasound imaging probe to produce real-time imaging. Methods of using the probes and systems to move kidney stones are also provided.
    Type: Application
    Filed: October 19, 2015
    Publication date: August 31, 2017
    Applicants: University of Washington, Sonomotion, Inc.
    Inventors: Michael R. Bailey, Bryan Cunitz, Barbrina Dunmire, Adam Maxwell, Oren Levy
  • Publication number: 20170232277
    Abstract: An ultrasound therapy system is provided that can include any number of features. In some embodiments, the custom transducer housings can be manufactured using a rapid-prototyping method to arrange a plurality of single-element, substantially flat transducers to share a common focal point. The rapid-prototyping method can include, for example, fused-deposition modeling, 3D printing, and stereolithography. In some embodiments, the therapy system can include a plurality of transducer modules insertable into the openings of the transducer housing. Methods of manufacture are also described, including designing a transducer housing shell to a desired geometry and a plurality of acoustic focusing lenses integral to the transducer housing shell in a 3D computer aided design software, and constructing the transducer housing shell and the plurality of acoustic focusing lenses integral to the transducer housing shell using a rapid-prototyping method.
    Type: Application
    Filed: May 1, 2017
    Publication date: August 17, 2017
    Inventors: Timothy L. HALL, Adam MAXWELL, Charles A. CAIN, Yohan KIM, Zhen XU
  • Patent number: 9636133
    Abstract: An ultrasound therapy system is provided that can include any number of features. In some embodiments, the custom transducer housings can be manufactured using a rapid-prototyping method to arrange a plurality of single-element, substantially flat transducers to share a common focal point. The rapid-prototyping method can include, for example, fused-deposition modeling, 3D printing, and stereolithography. In some embodiments, the therapy system can include a plurality of transducer modules insertable into the openings of the transducer housing. Methods of manufacture are also described, including designing a transducer housing shell to a desired geometry and a plurality of acoustic focusing lenses integral to the transducer housing shell in a 3D computer aided design software, and constructing the transducer housing shell and the plurality of acoustic focusing lenses integral to the transducer housing shell using a rapid-prototyping method.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: May 2, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Timothy L. Hall, Adam Maxwell, Charles A. Cain, Yohan Kim, Zhen Xu
  • Publication number: 20170000376
    Abstract: Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as “boiling histotripsy” (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.
    Type: Application
    Filed: March 27, 2015
    Publication date: January 5, 2017
    Inventors: Ari PARTANEN, Vera KHOKHLOVA, Navid FARR, Donghoon LEE, Wayne KREIDER, Tatiana KHOKHLOVA, Adam MAXWELL, Yak-Nam WANG, George SCHADE, Michael BAILEY
  • Publication number: 20160287909
    Abstract: Methods for diagnosing a pathologic tissue membrane, as well as a focused ultrasound apparatus and methods of treatment are disclosed to perform ureterocele puncture noninvasively using focused ultrasound-generated cavitation or boiling bubbles to controllably erode a hole through the tissue. An example ultrasound apparatus may include (a) a therapy transducer having a treatment surface, wherein the therapy transducer comprises a plurality of electrically isolated sections, (b) at least one concave acoustic lens defining a therapy aperture in the treatment surface of the therapy transducer, (c) an imaging aperture defined by either the treatment surface of the therapy transducer or by the at least one concave acoustic lens and (d) an ultrasound imaging probe axially aligned with a central axis of the therapy aperture.
    Type: Application
    Filed: March 28, 2014
    Publication date: October 6, 2016
    Inventors: Adam Maxwell, Ryan Hsi, Thomas Lendvay, Pasquale Casale, Michael Bailey
  • Publication number: 20160184616
    Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
    Type: Application
    Filed: August 22, 2014
    Publication date: June 30, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Charles A. CAIN, Adam MAXWELL, Zhen XU, Kuang-Wei LIN