Patents by Inventor Adam Maxwell

Adam Maxwell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11007573
    Abstract: This invention relates generally to novel methods and novel devices for the continuous manufacture of nanoparticles, microparticles and nanoparticle/liquid solution(s) (e.g., colloids). The nanoparticles (and/or micron-sized particles) comprise a variety of possible compositions, sizes and shapes. The particles (e.g., nanoparticles) are caused to be present (e.g., created and/or the liquid is predisposed to their presence (e.g., conditioned)) in a liquid (e.g., water) by, for example, preferably utilizing at least one adjustable plasma (e.g., created by at least one AC and/or DC power source), which plasma communicates with at least a portion of a surface of the liquid. At least one subsequent and/or substantially simultaneous adjustable electrochemical processing technique is also preferred. Multiple adjustable plasmas and/or adjustable electrochemical processing techniques are preferred. Processing enhancers can be utilized alone or with a plasma. Semicontinuous and batch processes can also be utilized.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: May 18, 2021
    Inventors: David Kyle Pierce, Mark Gordon Mortenson, David Andrew Bryce, Adam Robert Dorfman, Mikhail Merzliakov, Arthur Maxwell Grace
  • Publication number: 20210008394
    Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
    Type: Application
    Filed: August 31, 2020
    Publication date: January 14, 2021
    Inventors: Charles A. CAIN, Adam MAXWELL, Zhen XU, Kuang-Wei LIN
  • Patent number: 10780298
    Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: September 22, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Charles A. Cain, Adam Maxwell, Zhen Xu, Kuang-Wei Lin
  • Patent number: 10694974
    Abstract: Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as “boiling histotripsy” (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: June 30, 2020
    Assignees: UNIVERSITY OF WASHINGTON, KONINKLIJKE PHILIPS N.V.
    Inventors: Ari Partanen, Vera Khokhlova, Navid Farr, Donghoon Lee, Wayne Kreider, Tatiana Khokhlova, Adam Maxwell, Yak-Nam Wang, George Schade, Michael Bailey
  • Patent number: 10667831
    Abstract: Disclosed herein are ultrasonic probes and systems incorporating the probes. The probes are configured to produce an ultrasonic therapy exposure that, when applied to a kidney stone, will exert an acoustic radiation force sufficient to produce ultrasonic propulsion. Unlike previous probes configured to produce ultrasonic propulsion, however, the disclosed probes are engineered to produce a relatively large (both wide and long) therapy region effective to produce ultrasonic propulsion. This large therapy region allows the probe to move a plurality of kidney stones (or fragments from lithotripsy) in parallel, thereby providing the user the ability to clear several stones from an area simultaneously. This “broadly focused” probe is, in certain embodiments, combined in a single handheld unit with a typical ultrasound imaging probe to produce real-time imaging. Methods of using the probes and systems to move kidney stones are also provided.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: June 2, 2020
    Assignees: University of Washington, Sonomotion, Inc.
    Inventors: Michael R. Bailey, Bryan Cunitz, Barbrina Dunmire, Adam Maxwell, Oren Levy
  • Publication number: 20200078608
    Abstract: Methods for diagnosing a pathologic tissue membrane, as well as a focused ultrasound apparatus and methods of treatment are disclosed to perform ureterocele puncture noninvasively using focused ultrasound-generated cavitation or boiling bubbles to controllably erode a hole through the tissue. An example ultrasound apparatus may include (a) a therapy transducer having a treatment surface, wherein the therapy transducer comprises a plurality of electrically isolated sections, (b) at least one concave acoustic lens defining a therapy aperture in the treatment surface of the therapy transducer, (c) an imaging aperture defined by either the treatment surface of the therapy transducer or by the at least one concave acoustic lens and (d) an ultrasound imaging probe axially aligned with a central axis of the therapy aperture.
    Type: Application
    Filed: June 20, 2019
    Publication date: March 12, 2020
    Applicants: University of Washington through its Center for Commercialization, The Trustees of Columbia University in the City of New York
    Inventors: Adam Maxwell, Ryan Hsi, Thomas Lendvay, Pasquale Casale, Michael Bailey
  • Patent number: 10350439
    Abstract: Methods for diagnosing a pathologic tissue membrane, as well as a focused ultrasound apparatus and methods of treatment are disclosed to perform ureterocele puncture noninvasively using focused ultrasound-generated cavitation or boiling bubbles to controllably erode a hole through the tissue. An example ultrasound apparatus may include (a) a therapy transducer having a treatment surface, wherein the therapy transducer comprises a plurality of electrically isolated sections, (b) at least one concave acoustic lens defining a therapy aperture in the treatment surface of the therapy transducer, (c) an imaging aperture defined by either the treatment surface of the therapy transducer or by the at least one concave acoustic lens and (d) an ultrasound imaging probe axially aligned with a central axis of the therapy aperture.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: July 16, 2019
    Assignees: University of Washington through its Center for Commercialization, The Trustees of Columbia University in the City of New York
    Inventors: Adam Maxwell, Ryan Hsi, Thomas Lendvay, Pasquale Casale, Michael Bailey
  • Publication number: 20190200656
    Abstract: In one embodiment, a method for creating a food product is provided. The method may include providing a portion of egg base, the egg base including water and egg solids; providing a portion of cations; mixing the water, the egg solids, and the cation portion; and heating the mixture. The cation portion may include at least one of Zinc, Manganese, and Copper cations. In another embodiment, a food product is provided. The food product may include cooked egg; and Sulfur-containing salts of at least one of Zinc, Manganese, and Copper. The food product may contain between 0.25 and 10 mg of metal components of the Sulfur-containing salts per 0.967 g egg white solids and between 0.25 and 10 mg of metal components of the Sulfur-containing salts per 5.35 g egg yolk solids.
    Type: Application
    Filed: December 28, 2018
    Publication date: July 4, 2019
    Inventors: Sharat JONNALAGADDA, Adam MAXWELL, Leslie MORGRET, Niva CHAPA
  • Patent number: 10219815
    Abstract: Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as “Thrombolysis.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: March 5, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Adam Maxwell, Zhen Xu, Hitinder S. Gurm, Charles A. Cain
  • Publication number: 20170245874
    Abstract: Disclosed herein are ultrasonic probes and systems incorporating the probes. The probes are configured to produce an ultrasonic therapy exposure that, when applied to a kidney stone, will exert an acoustic radiation force sufficient to produce ultrasonic propulsion. Unlike previous probes configured to produce ultrasonic propulsion, however, the disclosed probes are engineered to produce a relatively large (both wide and long) therapy region effective to produce ultrasonic propulsion. This large therapy region allows the probe to move a plurality of kidney stones (or fragments from lithotripsy) in parallel, thereby providing the user the ability to clear several stones from an area simultaneously. This “broadly focused” probe is, in certain embodiments, combined in a single handheld unit with a typical ultrasound imaging probe to produce real-time imaging. Methods of using the probes and systems to move kidney stones are also provided.
    Type: Application
    Filed: October 19, 2015
    Publication date: August 31, 2017
    Applicants: University of Washington, Sonomotion, Inc.
    Inventors: Michael R. Bailey, Bryan Cunitz, Barbrina Dunmire, Adam Maxwell, Oren Levy
  • Publication number: 20170232277
    Abstract: An ultrasound therapy system is provided that can include any number of features. In some embodiments, the custom transducer housings can be manufactured using a rapid-prototyping method to arrange a plurality of single-element, substantially flat transducers to share a common focal point. The rapid-prototyping method can include, for example, fused-deposition modeling, 3D printing, and stereolithography. In some embodiments, the therapy system can include a plurality of transducer modules insertable into the openings of the transducer housing. Methods of manufacture are also described, including designing a transducer housing shell to a desired geometry and a plurality of acoustic focusing lenses integral to the transducer housing shell in a 3D computer aided design software, and constructing the transducer housing shell and the plurality of acoustic focusing lenses integral to the transducer housing shell using a rapid-prototyping method.
    Type: Application
    Filed: May 1, 2017
    Publication date: August 17, 2017
    Inventors: Timothy L. HALL, Adam MAXWELL, Charles A. CAIN, Yohan KIM, Zhen XU
  • Patent number: 9636133
    Abstract: An ultrasound therapy system is provided that can include any number of features. In some embodiments, the custom transducer housings can be manufactured using a rapid-prototyping method to arrange a plurality of single-element, substantially flat transducers to share a common focal point. The rapid-prototyping method can include, for example, fused-deposition modeling, 3D printing, and stereolithography. In some embodiments, the therapy system can include a plurality of transducer modules insertable into the openings of the transducer housing. Methods of manufacture are also described, including designing a transducer housing shell to a desired geometry and a plurality of acoustic focusing lenses integral to the transducer housing shell in a 3D computer aided design software, and constructing the transducer housing shell and the plurality of acoustic focusing lenses integral to the transducer housing shell using a rapid-prototyping method.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: May 2, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Timothy L. Hall, Adam Maxwell, Charles A. Cain, Yohan Kim, Zhen Xu
  • Publication number: 20170000376
    Abstract: Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as “boiling histotripsy” (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.
    Type: Application
    Filed: March 27, 2015
    Publication date: January 5, 2017
    Inventors: Ari PARTANEN, Vera KHOKHLOVA, Navid FARR, Donghoon LEE, Wayne KREIDER, Tatiana KHOKHLOVA, Adam MAXWELL, Yak-Nam WANG, George SCHADE, Michael BAILEY
  • Publication number: 20160287909
    Abstract: Methods for diagnosing a pathologic tissue membrane, as well as a focused ultrasound apparatus and methods of treatment are disclosed to perform ureterocele puncture noninvasively using focused ultrasound-generated cavitation or boiling bubbles to controllably erode a hole through the tissue. An example ultrasound apparatus may include (a) a therapy transducer having a treatment surface, wherein the therapy transducer comprises a plurality of electrically isolated sections, (b) at least one concave acoustic lens defining a therapy aperture in the treatment surface of the therapy transducer, (c) an imaging aperture defined by either the treatment surface of the therapy transducer or by the at least one concave acoustic lens and (d) an ultrasound imaging probe axially aligned with a central axis of the therapy aperture.
    Type: Application
    Filed: March 28, 2014
    Publication date: October 6, 2016
    Inventors: Adam Maxwell, Ryan Hsi, Thomas Lendvay, Pasquale Casale, Michael Bailey
  • Publication number: 20160184616
    Abstract: Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P?) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.
    Type: Application
    Filed: August 22, 2014
    Publication date: June 30, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Charles A. CAIN, Adam MAXWELL, Zhen XU, Kuang-Wei LIN
  • Publication number: 20160012185
    Abstract: In this era, secured electronic medical records are a given for medical decision making at point-of-care and continuity of care of patients. Multiple attempts are underway to pave way for a hundred percent use of electronic medical records. One such specialty paving the way is Cardiology; and the reason perhaps is the many life-saving devices that are used and the numerous data that are accumulated over time. This invention concerns embedding patient data of cardiac implantable electronic devices, namely: pacemakers, defibrillators, combination of the these two devices, cardiac resynchronization therapy, implantable cardioverter defibrillators, and combination of this with a defibrillator into a phone and tablet application for ios, android and other phone platforms MY PACER APP.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 14, 2016
    Applicant: PHYSICIANS CREEK INC
    Inventor: Adam Maxwell AU
  • Publication number: 20150320384
    Abstract: A system and method for detecting, via ultrasound, a concretion in a subject are provided. One or more ultrasound pulses are transmitted into the concretion and at least one object of interest, such as a bubble, present in the concretion. Reflection signals from the concretion and the bubble are then contrasted using the twinkling artifact, and a filter removes motion signals. An output device, such as a display, provides an indication of the presence of the concretion based on the reflection signals.
    Type: Application
    Filed: May 6, 2015
    Publication date: November 12, 2015
    Inventors: Bryan Cunitz, Wei Lu, Neil Owen, Oleg A. Sapozhnikov, Michael R. Bailey, Lawrence A. Crum, John Kucewicz, Barbrina Dunmire, Adam Maxwell, Mathew D. Sorensen
  • Publication number: 20140100459
    Abstract: A Histotripsy therapy system is provided that can include any number of features. In some embodiments, the system includes a high voltage power supply, a pulse generator electrically coupled to at least one signal switching amplifier, at least one matching network electrically coupled to the signal switching amplifier(s), and an ultrasound transducer having at least one transducer element. The Histotripsy therapy system can further include an ultrasound Doppler imaging system. The Doppler imaging system and the Histotripsy therapy system can be synchronized to enable color Doppler acquisition of the fractionation of tissue during Histotripsy therapy. Methods of use are also described.
    Type: Application
    Filed: October 4, 2013
    Publication date: April 10, 2014
    Inventors: Zhen XU, Ryan M. MILLER, Adam MAXWELL, Charles A. CAIN
  • Publication number: 20130289593
    Abstract: An ultrasound therapy system is provided that can include any number of features. In some embodiments, the custom transducer housings can be manufactured using a rapid-prototyping method to arrange a plurality of single-element, substantially flat transducers to share a common focal point. The rapid-prototyping method can include, for example, fused-deposition modeling, 3D printing, and stereolithography. In some embodiments, the therapy system can include a plurality of transducer modules insertable into the openings of the transducer housing. Each transducer module can include an acoustic lens, a substantially flat, single-element transducer, and a matching layer disposed between the lens and the transducer. Methods of use and manufacture are also described.
    Type: Application
    Filed: April 30, 2013
    Publication date: October 31, 2013
    Inventors: Timothy L. Hall, Adam Maxwell, Charles A. Cain, Yohan Kim, Zhen Xu
  • Patent number: 8539813
    Abstract: A cavitational ultrasound (e.g., Histotripsy) gel phantom and cavitational ultrasound testing system are provided that may include any of a number of features. One feature of the phantom and system is that it can allow for instant visual feedback on the efficacy and dosage of a Histotripsy transducer. The changes in the gel phantom can be visualized with the naked eye without having to wait for histology. The changes in the gel phantom can also be visualized with a camera, with ultrasound imaging, or with microscopy. In various embodiments, the phantom includes indicators such as carbon particles, dye-encapsulated beads, and red blood cells. Methods associated with use of the cavitational ultrasound gel phantom and testing system are also covered.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: September 24, 2013
    Assignee: The Regents of the University of Michigan
    Inventors: Charles A. Cain, Zhen Xu, Adam Maxwell, Tzu-Yin Wang, Simone Park