Patents by Inventor Adam Mirando

Adam Mirando has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying and preparing pharmaceutical agents for activating Tie1 and/or Tie2 receptors
    Patent number: 11674959
    Abstract: The present invention in various aspects and embodiments involves pharmaceutical compositions prepared by contacting a candidate ?- or ?-integrin-binding molecule, or panel thereof, with an integrin heterodimer, and quantifying heterodimer disruption by the candidate molecule. An integrin-binding molecule, or derivative thereof, that disrupts the integrin heterodimer is selected and is formulated into a pharmaceutical composition for administration to a subject, e.g., who has a disease or disorder related to abnormal vascularization.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: June 13, 2023
    Assignees: The Johns Hopkins University, AsclepiX Therapeutics, Inc.
    Inventors: Niranjan Pandey, Aleksander S. Popel, Jordan J. Green, Adam Mirando
  • METHODS FOR IDENTIFYING AND PREPARING PHARMACEUTICAL AGENTS FOR ACTIVATING TIE2 RECEPTOR
    Publication number: 20210132062
    Abstract: The present invention in various aspects and embodiments involves pharmaceutical compositions prepared by contacting a candidate ?- or ?-integrin-binding molecule, or panel thereof, with an integrin heterodimer, and quantifying heterodimer disruption by the candidate molecule. An integrin-binding molecule, or derivative thereof, that disrupts the integrin heterodimer is selected and is formulated into a pharmaceutical composition for administration to a subject, e.g., who has a disease or disorder related to abnormal vascularization.
    Type: Application
    Filed: August 3, 2018
    Publication date: May 6, 2021
    Inventors: Niranjan PANDEY, Aleksander S. POPEL, Jordan J. GREEN, Adam MIRANDO
  • BIODEGRADABLE MICROPARTICLES FOR SUSTAINED DELIVERY OF ANTI-ANGIOGENIC PEPTIDE
    Publication number: 20200179285
    Abstract: The present invention provides microparticle compositions comprising anti-angiogenic peptides, as well as methods of treatment, including for macular degeneration.
    Type: Application
    Filed: May 8, 2018
    Publication date: June 11, 2020
    Inventors: Jordan J. GREEN, Niranjan PANDEY, Aleksander S. POPEL, Peter A. CAMPOCHIARO, Jayoung KIM, Raquel LIMA E. SILVA, Ron SHMUELI, Adam MIRANDO
  • COMPOUNDS AND METHODS FOR ACTIVATING TIE2 SIGNALING
    Publication number: 20190225670
    Abstract: The present invention in various aspects and embodiments, involves methods for treating Tie2-related vascular permeability by administering one or more collagen IV-derived biomimetic peptides and involves compositions for treating Tie2-related vascular permeability comprising one or more collagen IV-derived biomimetic peptides. Such peptides can promote the Tie2 agonist activities of Angiopoietin 2 (Ang2), thereby stabilizing vasculature and/or lymphatic vessels.
    Type: Application
    Filed: October 4, 2017
    Publication date: July 25, 2019
    Inventors: Niranjan B. Pandey, Adam Mirando, Aleksander S. Popel, Jordan J. Green