Abstract: The invention relates to cocrystals comprising a substituted 2-oxo-1-pyrrolidinyl triazole of formula (I) and a carboxylic acid of formula (II).

Abstract: Aspects of the present disclosure include methods, systems, and non-transitory computer readable media for receiving a plurality of reception magnetic signals, determining state information associated with each marker of the plurality of markers based on a corresponding transmission magnetic signal of the plurality of transmission magnetic signals and a corresponding reception magnetic signal of the plurality of reception magnetic signals, and determining tag information based on the state information of the plurality of markers.

Abstract: The present invention relates to crystalline forms of entrectinib, processes for their preparation, and to pharmaceutical compositions containing the crystalline forms.

Abstract: The present invention provides a molecular complex of binimetinib, which is binimetinib dimethylsulfoxide (DMSO) solvate. It is also an object of the present invention to provide a molecular complex of binimetinib which is a crystalline molecular complex of binimetinib and citric acid. The present invention also relates to methods for the preparation of these molecular complexes.

Abstract: A device for connecting to the intake manifold of an internal combustion engine, the device having at least one grooved aperture for manipulating airflow through the device as the airflow moves into the intake manifold of the engine. The grooved aperture consists of a series of concentric and parallel grooved sections, each section having a minor diameter and a major diameter and incrementally increasing diameters therebetween, such that each section forms a frustum, such that the length of the aperture has a grooved internal surface that provides structure for manipulating the airflow through the device.

Abstract: A unique backup ring against ends of a sealing element features axial slots extending part way along a cylindrical segment of the backup ring. The slots end in rounded openings to relieve stress and a part of the cylindrical shape of the backup ring is solid. The slotted end of the cylindrical portion is tapered in section toward the end overlapping the sealing element. The face of the backup ring away from the sealing element is tapered and rides on an adjacent tapered surface away from the mandrel during the setting. The tapered seal end of the backup ring bends to reach the surrounding tubular before the balance of the cylindrical portion reaches the surrounding tubular. Extrusion along the mandrel is stopped by a mandrel seal on an adjacent wedge ring. The mandrel end of the backup ring has a peripheral stiffener to lend rigidity.

Abstract: A unique backup ring against ends of a sealing element features axial slots extending part way along a cylindrical segment of the backup ring. The slots end in rounded openings to relieve stress and a part of the cylindrical shape of the backup ring is solid. The slotted end of the cylindrical portion is tapered in section toward the end overlapping the sealing element. The face of the backup ring away from the sealing element is tapered and rides on an adjacent tapered surface away from the mandrel during the setting. The tapered seal end of the backup ring bends to reach the surrounding tubular before the balance of the cylindrical portion reaches the surrounding tubular. Extrusion along the mandrel is stopped by a mandrel seal on an adjacent wedge ring. The mandrel end of the backup ring has a peripheral stiffener to lend rigidity.

Abstract: A cooler includes a bottom wall and a plurality of side walls connected to the bottom wall. At least one of the sidewalls has a transparent portion. A lid is connected to the side walls such that the bottom wall, side walls, and lid cooperate to define an interior space. At least one cup holder is formed in the bottom wall and positioned within the interior space. At least one first interior wall defines a receptacle within the interior space for receiving at least one of dry goods, food, and utensils. A second interior wall defines a chamber within the interior space for receiving cold items.

Abstract: A cooler includes a bottom wall and a plurality of side walls connected to the bottom wall. At least one of the sidewalls has a transparent portion. A lid is connected to the side walls such that the bottom wall, side walls, and lid cooperate to define an interior space. At least one cup holder is formed in the bottom wall and positioned within the interior space. At least one first interior wall defines a receptacle within the interior space for receiving at least one of dry goods, food, and utensils. A second interior wall defines a chamber within the interior space for receiving cold items.

Abstract: A cooler includes a bottom wall and a plurality of side walls connected to the bottom wall. At least one of the sidewalls has a transparent portion. A lid is connected to the side walls such that the bottom wall, side walls, and lid cooperate to define an interior space. At least one cup holder is formed in the bottom wall and positioned within the interior space. At least one first interior wall defines a receptacle within the interior space for receiving at least one of dry goods, food, and utensils. A second interior wall defines a chamber within the interior space for receiving cold items.

Abstract: The present invention relates to a novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy (GDEPT) and antibody-directed enzymeprodrug therapy (ADEPT), in conjunction with nitroreductase enzymes.