Abstract: A pipe fitting (100) includes a tubular connecting part (101); the tubular connecting part being configured to be inserted into an expanded pipe end section (111) of a pipe (110) having a first circumferential intact sealing region (113) on the inner surface (112) of the pipe end section (111); the tubular connecting part comprising a first radially outwards extending circumferential sealing barb (105?) positioned for engaging, when in use, with the first circumferential intact sealing region during shrinkage of the pipe end section for forming a sealing between the pipe fitting and the pipe.

Abstract: Methods for detecting a genetic mutation in target nucleotide sequences by sorting the target nucleotide sequences into bins, aligning the target nucleotide sequences in each bin with reference nucleotide sequences, and quantifying the number of target nucleotide sequences that align with reference sequences. Systems and kits for detecting a genetic mutation in target nucleotide sequences.

Abstract: Methods for detecting a genetic mutation in target nucleotide sequences by sorting the target nucleotide sequences into bins, aligning the target nucleotide sequences in each bin with reference nucleotide sequences, and quantifying the number of target nucleotide sequences that align with reference sequences. Systems and kits for detecting a genetic mutation in target nucleotide sequences.

Abstract: Disclosed are methods, assays, and compositions for detecting the presence of a kinase inhibitor resistance. The disclosed method and primer panels work with any method for detecting nucleic acid variation in a sample including, but not limited to next generation sequencing.

Abstract: This invention provides methods, compositions, and kits relating to gene product biomarkers where gene expression levels are correlated with therapeutic response of rheumatoid arthritis patients to treatment with an IL-6 receptor antagonist, such as an IL6-R antibody. The methods, compositions, and kits of the invention can be used to identify rheumatoid arthritis patients who are likely, or not likely, to respond to IL-6 receptor antagonist treatments.

Abstract: The present invention provides single nucleotide polymorphisms (SNPs) associated with clinical responsiveness of rheumatoid arthritis patients to treatment with an interleukin-6 receptor antibody such as tocilizumab, and methods of using such SNPs for predicting clinical response to treatment with the antibody.

Abstract: A valve comprises a housing and at least three ceramic discs in the housing such that at least two fixed ceramic discs are provided and at least one rotatable ceramic disc is provided between the fixed ceramic discs. The ceramic discs comprise through holes such that when the holes are aligned, the valve is open, and turning the rotatable ceramic disc turns the holes to be misaligned in successive ceramic discs, which prevents water flow through the valve. The valve further comprises a handle for rotating a rotatable ceramic disc and the handle comprises a stem extending through the housing, and a curved part, the curved part curving at least partly around the housing along the circumference of the housing.

Abstract: A valve comprises a housing and at least three ceramic discs in the housing such that at least two fixed ceramic discs are provided and at least one rotatable ceramic disc is provided between the fixed ceramic discs. The ceramic discs comprise through holes such that when the holes are aligned, the valve is open, and turning the rotatable ceramic disc turns the holes to be misaligned in successive ceramic discs, which prevents water flow through the valve. The valve further comprises a handle for rotating a rotatable ceramic disc and the handle comprises a stem extending through the housing, and a curved part, the curved part curving at least partly around the housing along the circumference of the housing.