Abstract: The disclosure provides methods of treating a wound using negative pressure wound therapy by contacting a wound with a porous fibrin foam dressing and applying negative pressure on the wound, wherein the fibrin foam includes a three-dimensional reaction product of fibrinogen and thrombin and is biodegradable in vivo. Further provided is a dressing material for negative pressure wound therapy comprising a porous fibrin foam that can substantially conform to a shape of the wound, wherein the fibrin foam includes a three-dimensional reaction product of fibrinogen and thrombin, is biodegradable in vivo, and does not need to be changed during the course of therapy.