Abstract: The disclosure provides methods for treating major depressive disorder in a human patient having moderate or severe anhedonia. The methods comprise administering to the patient in need thereof an effective amount of aticaprant, or a pharmaceutically acceptable salt thereof. In some embodiments, the patient had an inadequate response to other antidepressant therapy prior to treatment with aticaprant. In other embodiments, the other antidepressant therapy comprised a selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), or a combination thereof.

Abstract: The disclosure provides methods for treating major depressive disorder in a human patient having moderate or severe anhedonia. The methods comprise administering to the patient in need thereof an effective amount of aticaprant, or a pharmaceutically acceptable salt thereof. In some embodiments, the patient had an inadequate response to other antidepressant therapy prior to treatment with aticaprant. In other embodiments, the other antidepressant therapy comprised a selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor (SNRI), or a combination thereof.

Abstract: The disclosure provides crystalline and amorphous forms of aticaprant. Also provided by the disclosure are pharmaceutical compositions comprising the amorphous or crystalline forms, methods of treating major depressive disorder using the amorphous or crystalline forms of aticaprant, amorphous or crystalline forms of aticaprant for use in the treatment of major depressive disorder in a human patient having anhedonia, uses of the amorphous or crystalline forms of aticaprant in the manufacture of a medicament for the treatment of major depressive disorder, and packages or pharmaceutical products comprising (i) amorphous or crystalline forms of aticaprant and (ii) instructions for treating major depressive disorder. In some aspects, the human patient treated as described herein has anhedonia.

Abstract: An amusement system features an interactive floor with an array of panels laid out in one or more grids to collectively define an interactive floor surface, an illumination system operable to individually illuminate each panel, and a sensing system operable to detect presence of any participant atop any panel. A base frame of the interactive floor is composed of a plurality of base modules seated on a subfloor, and supporting a respective panel for one or more cells of the interactive floor. The base modules are not directly fastened together, and instead are only intercoupled by perimeter seals applied over peripheral regions of the panels of neighbouring modules. Separation of the modules is constrained by surrounding walls of a room fully occupied by the interactive floor. In gameplay, some panels are distinctively illuminated as hazards to be avoided by participants, subject to penalty.

Abstract: The present invention relates to a modular storage system for barrels. The modular storage system includes a base rick module, an aisle rick module, and an end rick module, whereby a plurality of each module type may be assembled to construct a rickhouse.

Abstract: The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the Factor XII (F12) gene. The invention also relates to methods of using such RNAi agents to inhibit expression of an F12 gene and to methods of preventing and treating an F12-associated disorder, e.g., heredity angioedema (HAE), prekallikrein deficiency, malignant essential hypertension, hypertension, end stage renal disease, Fletcher Factor Deficiency, thromboembolic disease, inflammatory disease, or Alzheimer's Disease.

Abstract: A system can include an emitter structure connected to a reservoir containing a working material, wherein the working material is in electrical communication with a first electrode, an electrode opposing the emitter structure across a gap; and optionally a frame holding the emitter structure and the electrode.

Abstract: A respiratory treatment device comprising at least one chamber, a chamber inlet configured to receive air into the at least one chamber, at least one chamber outlet configured to permit air to exit the at least one chamber, and a flow path defined between the chamber inlet and the at least one chamber outlet. A restrictor member positioned in the flow path is moveable between a closed position, where a flow of air along the flow path is restricted, and an open position, where the flow of air along the flow path is less restricted. A vane in fluid communication with the flow path is operatively connected to the restrictor member and is configured to reciprocate between a first position and a second position in response to the flow of air along the flow path.

Abstract: An amusement attraction features a wall structure, a respective set of illuminable handholds distributed over a wall surface of at least one upright wall of the structure, a floor surface residing adjacent to the upright wall on a side thereof faced by the wall surface, and one or more detection devices operable to detect landing of a participant on the floor surface during attempted traversal of the wall surface. A controller is operable to illuminate the handholds in different colour-coded patterns. Each pattern includes illumination of “authorized” handholds in a first colour, illumination of “prohibited” handholds in a second colour, and illumination of “targeted” handholds in a third colour. In a game-play session, participants are tasked with grasping of the targeted handholds while traversing the wall structure, with penalties applied for detected landing of participants on the floor surface and gripping of prohibited handholds.

Abstract: An amusement system features an interactive floor with an array of panels laid out in one or more grids to collectively define an interactive floor surface, an illumination system operable to individually illuminate each panel, and a sensing system operable to detect presence of any participant atop any panel. A base frame of the interactive floor is composed of a plurality of base modules seated on a subfloor, and supporting a respective panel for one or more cells of the interactive floor. The base modules are not directly fastened together, and instead are only intercoupled by perimeter seals applied over peripheral regions of the panels of neighbouring modules. Separation of the modules is constrained by surrounding walls of a room fully occupied by the interactive floor. In gameplay, some panels are distinctively illuminated as hazards to be avoided by participants, subject to penalty.

Abstract: An immersive amusement system features a path to be traversed by participants, a first array of devices mounted on a first side of said path, and a second array of devices mounted on an opposing second side of said path. Each device comprises either a beam emitter operable to transmit a respective visible beam, or a beam receiver operable to detect receipt thereby of a visible beam. The arrayed devices are setup in co-operable pairs, of which each co-operable pair comprises a beam emitter in one of said arrays and a corresponding beam receiver in the other of said arrays. A controller operably connected to the arrayed devices is configured to selectively activate and deactivate said beam emitters to cause transmission of visible beams from said beam emitters to said corresponding beam receivers, and to monitor for breaking of any of said visible beams by any of said participants.

Abstract: An amusement system features an interactive floor with an array of panels laid out in one or more grids to collectively define an interactive floor surface, an illumination system operable to individually illuminate each panel, and a sensing system operable to detect presence of any participant atop any panel. A base frame of the interactive floor is composed of a plurality of base modules seated on a subfloor, and supporting a respective panel for one or more cells of the interactive floor. The base modules are not directly fastened together, and instead are only intercoupled by perimeter seals applied over peripheral regions of the panels of neighbouring modules. Separation of the modules is constrained by surrounding walls of a room fully occupied by the interactive floor. In gameplay, some panels are distinctively illuminated as hazards to be avoided by participants, subject to penalty.

Abstract: An immersive gaming facility has a plurality of game rooms, each with a respective interactive gaming space with electronically controlled interactive game elements, a respective entrance through which participants are admissible from a waiting area with a respective sign-in station operable to control admission of participants in a groupwise fashion. After admission, an executed game session involves controlled operation of the interactive game elements and monitoring of participant interaction therewith to identify participant completion or failure of tasks in said game session; and terminate execution of said game session upon expiry of a time limit or multiple detected failures exceeding a predetermined limit. The waiting areas are accessible independently of one another off a shared common area, allowing participation among the game rooms in any participant-selected order. The gaming spaces are darkened environments illuminated only by the interactive game elements and game status displays.

Abstract: An immersive gaming facility has a plurality of game rooms, each with a respective interactive gaming space with electronically controlled interactive game elements, a respective entrance through which participants are admissible from a waiting area with a respective sign-in station operable to control admission of participants in a groupwise fashion. After admission, an executed game session involves controlled operation of the interactive game elements and monitoring of participant interaction therewith to identify participant completion or failure of tasks in said game session; and terminate execution of said game session upon expiry of a time limit or multiple detected failures exceeding a predetermined limit. The waiting areas are accessible independently of one another off a shared common area, allowing participation among the game rooms in any participant-selected order. The gaming spaces are darkened environments illuminated only by the interactive game elements and game status displays.

Abstract: An immersive gaming facility has a plurality of game rooms, each with a respective interactive gaming space with electronically controlled interactive game elements, a respective entrance through which participants are admissible from a waiting area with a respective sign-in station operable to control admission of participants in a groupwise fashion. After admission, an executed game session involves controlled operation of the interactive game elements and monitoring of participant interaction therewith to identify participant completion or failure of tasks in said game session; and terminate execution of said game session upon expiry of a time limit or multiple detected failures exceeding a predetermined limit. The waiting areas are accessible independently of one another off a shared common area, allowing participation among the game rooms in any participant-selected order. The gaming spaces are darkened environments illuminated only by the interactive game elements and game status displays.

Abstract: An immersive amusement system features a path to be traversed by participants, a first array of devices mounted on a first side of said path, and a second array of devices mounted on an opposing second side of said path. Each device comprises either a beam emitter operable to transmit a respective visible beam, or a beam receiver operable to detect receipt thereby of a visible beam. The arrayed devices are setup in co-operable pairs, of which each co-operable pair comprises a beam emitter in one of said arrays and a corresponding beam receiver in the other of said arrays. A controller operably connected to the arrayed devices is configured to selectively activate and deactivate said beam emitters to cause transmission of visible beams from said beam emitters to said corresponding beam receivers, and to monitor for breaking of any of said visible beams by any of said participants.

Abstract: An amusement attraction features a wall structure, a respective set of illuminable handholds distributed over a wall surface of at least one upright wall of the structure, a floor surface residing adjacent to the upright wall on a side thereof faced by the wall surface, and one or more detection devices operable to detect landing of a participant on the floor surface during attempted traversal of the wall surface. A controller is operable to illuminate the handholds in different colour-coded patterns. Each pattern includes illumination of “authorized” handholds in a first colour, illumination of “prohibited” handholds in a second colour, and illumination of “targeted” handholds in a third colour. In a game-play session, participants are tasked with grasping of the targeted handholds while traversing the wall structure, with penalties applied for detected landing of participants on the floor surface and gripping of prohibited handholds.

Abstract: An amusement system features an interactive floor with an array of panels laid out in one or more grids to collectively define an interactive floor surface, an illumination system operable to individually illuminate each panel, and a sensing system operable to detect presence of any participant atop any panel. A base frame of the interactive floor is composed of a plurality of base modules seated on a subfloor, and supporting a respective panel for one or more cells of the interactive floor. The base modules are not directly fastened together, and instead are only intercoupled by perimeter seals applied over peripheral regions of the panels of neighbouring modules. Separation of the modules is constrained by surrounding walls of a room fully occupied by the interactive floor. In gameplay, some panels are distinctively illuminated as hazards to be avoided by participants, subject to penalty.

Abstract: An immersive gaming facility has a plurality of game rooms, each with a respective interactive gaming space with electronically controlled interactive game elements, a respective entrance through which participants are admissible from a waiting area with a respective sign-in station operable to control admission of participants in a groupwise fashion. After admission, an executed game session involves controlled operation of the interactive game elements and monitoring of participant interaction therewith to identify participant completion or failure of tasks in said game session; and terminate execution of said game session upon expiry of a time limit or multiple detected failures exceeding a predetermined limit. The waiting areas are accessible independently of one another off a shared common area, allowing participation among the game rooms in any participant-selected order. The gaming spaces are darkened environments illuminated only by the interactive game elements and game status displays.

Abstract: A high energy gas fracturing device, adapted to be lowered into a well. The device comprises a closed tube made of strong material, sized to fit into the well and having at least one sidewall, which defines a set of openings. A set of closure elements seal the openings in a water-tight manner. Also, a charge of propellant is located in the closed tube, the charge achieving best performance if kept dry. Finally, an ignition element contacts the charge.