Abstract: The invention relates to methods for treating prostate cancer by targeting the generation of splice variants of the androgen receptor. In one aspect, this can be achieved by targeting JMJD6 to reduce the production of androgen receptor splice variants. The invention finds particular use in the treatment of prostate cancer that is resistant to conventional androgen therapy.

Abstract: A pet securing device (1) comprises a holder (10) for releasably retaining a pet lead and a post (12) for insertion into the ground. The holder (10) is rotatable relative to the post (12). A kit of parts comprises a holder (10) for releasably retaining a pet lead and at least one post (12) for inserting into the ground, wherein the holder (10) is releasably attachable to the post (12) and the holder (10) is rotatable relative to the post (12) when attached to the post (12).

Abstract: A data processing system can receive, from a referring computing device, an indication to obtain electronic medical record data displayed by the referring computing device. The data processing system can obtain, via the computer network, the electronic medical record data, and can generate a referral request document based on the electronic medical record data. The data processing system can provide the referral request document from the referral network engine to the referring computing device via the computer network for display by the referring computing device, and can prompt for referral completion data using the referral request document. The data processing system can receive, via the computer network, an indication of a complete referral based on the referral completion data, and can obtain, by the data processing system, the complete referral.

Abstract: Systems and methods of providing information via a communications network are provided. A data processing system can obtain referral input data including at least one of subject condition data and remittance data, and can identify, from a database, service provider data associated with a service provider and based on the referral input data. At least one of the referral input data and the service provider data can be provided for display by a referring computing device associated with the data processing system, and a referral request can be sent via the communications network to a recipient computing device associated with the service provider. The referral request can include at least a portion of the referral input data. Responsive to the referral request, availability data of the service provider can be obtained based on at least one of the subject condition data and the remittance data.