Abstract: Provided herein are SARS-CoV-2 spike proteins and polypeptides (e.g., SARS-CoV-2 spike proteins and polypeptide immunogens (and immunogenic fragments and immunogenic variants thereof)) comprising at least one set of amino acid substitutions, and nucleic acid molecules encoding the same. Further provided herein are compositions (e.g., pharmaceutical compositions) and vaccines comprising the same for use in e.g., the prevention, treatment, and/or amelioration of a SARS-CoV-2 infection.

Abstract: Provided herein are polynucleotides (e.g., plasmids), including transfer polynucleotides and landing pad polynucleotides, which are useful, e.g., in the generation of cell and virion libraries each expressing and encoding a protein of interest (e.g., viral entry proteins). The libraries described herein are further useful, e.g., in methods of assessing functional characteristics of the proteins of interest (e.g., neutralization of viral entry proteins by one or more antibodies).

Abstract: The system and method described herein for providing scorecards to visualize services in an intelligent workload management system may include a computing environment having a model-driven, service-oriented architecture for creating collaborative threads to manage workloads. In particular, the management threads may converge information for describing services, applications, workloads, in an information technology infrastructure. For example, a discovery engine may reference an identity vault to capture enriched models of an infrastructure, and a management infrastructure may then generate one or more scorecards that can be used to manage the infrastructure. In particular, the scorecards may provide information for tuning or otherwise controlling risk, complexity, cost, availability, and agility versus rigidness in the infrastructure.

Abstract: The system and method described herein for providing scorecards to visualize services in an intelligent workload management system may include a computing environment having a model-driven, service-oriented architecture for creating collaborative threads to manage workloads. In particular, the management threads may converge information for describing services, applications, workloads, in an information technology infrastructure. For example, a discovery engine may reference an identity vault to capture enriched models of an infrastructure, and a management infrastructure may then generate one or more scorecards that can be used to manage the infrastructure. In particular, the scorecards may provide information for tuning or otherwise controlling risk, complexity, cost, availability, and agility versus rigidness in the infrastructure.