Abstract: Disclosed is a medicament dispenser for holding at least one elongate form medicament carrier. The elongate form medicament carrier has proximal and distal ends, and blister and lid elongate sheets enclosing multiple distinct medicament dose portions therebetween. The medicament dispenser has a dispensing mechanism which is adapted to operate, upon each actuation thereof, to dispense medicament active from the medicament dose portion. Moreover, the mechanism has at least one power spring mechanism for winding the lid elongate sheet, wherein the at least one power spring mechanism has at least one spring having an inner end about which the spring unwinds, and at least one shaft at which the inner end of at least one spring is secured. Furthermore, the power spring mechanism tensions and peels a segment of lid elongate sheet peeled from a corresponding segment of blister elongate sheet upon each actuation of the medicament dispenser.

Abstract: In general terms the present invention proposes a medicament dispenser 100 for use with at least one medicament carrier carrying multiple distinct medicament dose portions. The medicament dispenser 100 comprises: (a) a dispensing mechanism actuable for dispensing the dose portions carried by the at least one medicament carrier; (b) a mouthpiece 106; and (c) a cover for the mouthpiece, the cover being movably mounted to the dispenser 100 for sequential movement from a closed position in which the mouthpiece 106 is at least partially covered, to an open position in which the mouthpiece 106 is uncovered, via a first position, and optionally via a second position between the first position and the closed position that includes the closed position.

Abstract: Disclosed is a medicament dispenser for holding at least one elongate form medicament carrier. The elongate form medicament carrier has proximal and distal ends, and blister and lid elongate sheets enclosing multiple distinct medicament dose portions therebetween. The medicament dispenser has a dispensing mechanism which is adapted to operate, upon each actuation thereof, to dispense medicament active from the medicament dose portion. Moreover, the mechanism has at least one power spring mechanism for winding the lid elongate sheet, wherein the at least one power spring mechanism has at least one spring having an inner end about which the spring unwinds, and at least one shaft at which the inner end of at least one spring is secured. Furthermore, the power spring mechanism tensions and peels a segment of lid elongate sheet peeled from a corresponding segment of blister elongate sheet upon each actuation of the medicament dispenser.

Abstract: A nozzle arrangement for delivering a liquid from a liquid delivery device includes a nozzle having an inlet side for receiving a liquid to be delivered and an outlet side for delivering the liquid. The nozzle arrangement also includes a fixing device for fixing the nozzle in the delivery device and a recess located at the outlet side of the nozzle. The recess is arranged to wick away liquid deposited on the nozzle and/or fixing device.

Abstract: Disclosed is an elongate form medicament carrier and a medicament dispenser. The medicament carrier has a first end, a second end, and a central portion, and carrying multiple distinct medicament dose portions, the medicament dose portions consisting of a first set and a second set of medicament dose portions, the first set of medicament dose portions distributed in a first portion of the elongate form medicament carrier between the first end and the central portion of the elongate form medicament carrier and containing a medicament active, or a mixture of medicament actives, and the second set of medicament dose portions distributed in a second portion of the elongate form medicament carrier between the second end and the central portion of the elongate form medicament carrier and containing a medicament active, or a mixture of medicament actives, wherein the dose portions in the second set of medicament dose portions are different from the dose portions in the first set of medicament dose portions.

Abstract: A medicament dispenser, and a method of assembling a medicament dispenser, for holding at least one elongate form medicament carrier having blister and lid elongate sheets enclosing multiple distinct medicament dose portions therebetween. The medicament dispenser has a dispensing mechanism which is adapted to operate, upon each actuation thereof, to dispense medicament active from the medicament dose portion. Moreover, the mechanism has at least one power spring mechanism for winding the lid elongate sheet, wherein the at least one power spring mechanism has at least one spring having an inner end about which the spring unwinds, and at least one shaft at which the inner end of at least one spring is secured. Furthermore, the power spring mechanism tensions and peels a segment of lid elongate sheet peeled from a corresponding segment of blister elongate sheet upon each actuation of the medicament dispenser.

Abstract: In general terms the aspects of the disclosed embodiments proposes a dose counter for registering a count of doses dispensed from an inhaler. The dose counter includes a counter ring including a circumferential drive feature. The dose counter also includes a worm comprising a shaft and a gear extending in a helical path about the axis of the shaft for driving the counter ring. The gear includes recesses uniformly distributed along the helical path. The dose counter further includes a cylindrical body including an engagement feature for driving the gear, the engagement feature extending in a helical or spiral path from the cylindrical body to engage the gear such that relative rotational movement between the cylindrical body and the worm rotates the worm about its shaft.

Abstract: In general terms the present invention proposes a manifold 100 for delivery of medicament powder from a dispenser device. The manifold 100 comprises a first chamber 102 comprising a first chamber inlet 102A and a first chamber outlet 102B. The first chamber 102 is arranged to direct a first flow of air 110 from the first chamber inlet 102A to the first chamber outlet 102B. The manifold 100 also comprises a conduit 104 having a conduit inlet 104A and a conduit outlet 104B. The first chamber outlet 102B and conduit inlet 104A are arranged such that when a supply of medicament powder is positioned proximal thereto the first flow of air 110 is directed from the first chamber outlet 102B to the conduit inlet 104A via the supply of medicament powder to entrain the medicament powder and provide a flow of air entrained with medicament powder through the conduit 104.

Abstract: A method for testing the functionality of a liquid delivery device includes (i) fluidically connecting a liquid delivery device (or part thereof) to a pumping system; (ii) connecting the pumping system to a fluid reservoir; (iii) running the pumping system so that fluid from the reservoir is forced through the liquid delivery device (or part thereof) under pressure; (iv) measuring the pressure of the fluid as the fluid passes into the liquid delivery device (or part thereof); (v) comparing the plotted pressure with the test results for a nominal or within specification liquid delivery device (or part thereof).

Abstract: A method of pre-preparing a liquid delivery device valve includes (i) fluidically connecting at least that part of the liquid delivery device that contains the valve to a pumping system; (ii) connecting the pumping system to a fluid reservoir; (iii) running the pumping system so that fluid from the reservoir is forced through the valve under pressure, at a rate of flow that will cause necessary deformation and bedding-in of the valve.

Abstract: A liquid delivery device has a lower housing containing a reservoir and an upper housing containing a nozzle assembly with an upper tube housing, a passage formed through the upper tube housing between the reservoir and the nozzle assembly, the passage within the upper tube housing forming a metering chamber; the nozzle assembly converting liquid from the metering chamber to a droplet spray; the liquid delivery device having a one-way valve that locates and seals within the passage; the valve configured so that in a first state fluid flow through the passage is substantially blocked, and in a second state fluid can flow through the passage; the valve deforming from the first state to the second state, the upper tube housing comprising a recess at the upper end, the recess configured to receive and confine the outer side of the one-way valve.

Abstract: A portable inhaler, has a rotary actuation mechanism, including a follower component (104), a rotary loading device (106) and a button (112). The rotary loading device has a cam component (108) engaged with a cage component (110), to allow a predetermined limited rotational relative movement therebetween. The button is translatable between a central position and an extended position, and can be engaged by the cam component upon rotary movement of the rotary actuation mechanism to its primed position to translate the button to its extended position, and the button can engage the cam component to effect rotary movement of the rotary actuation mechanism to its actuated position as the button translates to its central position thereby releasing the follower component.

Abstract: An inhaler comprises a nozzle retaining structure comprising a nozzle retainer, the nozzle retainer comprising: a main body forming a central bowl comprising a rim, an aperture formed substantially at the well of the bowl, the aperture passing through the main body from one side to the other; the nozzle retaining structure and nozzle retainer configured so that a recess is formed between the nozzle retainer and the remainder of the nozzle retaining structure; at least one passage extending outwards towards the rim of the bowl from an inwards opening at or close to the well of the bowl, the passage comprising an at least partly open-topped channel formed through the wall of the central bowl.

Abstract: A dry powder inhalation device has a means to aerosolize powdered medicament and introduce the aerosolized medicament to an airflow directed to a user outlet. The device has a primary deagglomeration structure in the form of a baffle through which the airflow passes downstream of the means to aerosolize the powdered medicament and a secondary deagglomeration structure which is a tortuous passage through which the airflow passes downstream of the primary deagglomeration structure. The deagglomeration structures cause disruption to the airflow in their vicinity whereby the particles of the aerosolized powdered medicament are deagglomerated due to the primary deagglomeration structure and the secondary deagglomeration structure. The insert defines a tortuous passage which has a trajectory with a centre line, whereby the centre line has two or more major bends, involving a first point of inflection between a pair of adjacent bends of the two or more major bends.

Abstract: Disclosed is a medicament dispenser for holding at least one elongate form medicament carrier. The elongate form medicament carrier has proximal and distal ends, and blister and lid elongate sheets enclosing multiple distinct medicament dose portions therebetween. The medicament dispenser has a dispensing mechanism which is adapted to operate, upon each actuation thereof, to dispense medicament active from the medicament dose portion. Moreover, the mechanism has at least one power spring mechanism for winding the lid elongate sheet, wherein the at least one power spring mechanism has at least one spring having an inner end about which the spring unwinds, and at least one shaft at which the inner end of at least one spring is secured. Furthermore, the power spring mechanism tensions and peels a segment of lid elongate sheet peeled from a corresponding segment of blister elongate sheet upon each actuation of the medicament dispenser.

Abstract: In general terms the present invention proposes a medicament dispenser 100 for use with at least one medicament carrier carrying multiple distinct medicament dose portions. The medicament dispenser 100 comprises: (a) a dispensing mechanism actuable for dispensing the dose portions carried by the at least one medicament carrier; (b) a mouthpiece 106; and (c) a cover for the mouthpiece, the cover being movably mounted to the dispenser 100 for sequential movement from a closed position in which the mouthpiece 106 is at least partially covered, to an open position in which the mouthpiece 106 is uncovered, via a first position, and optionally via a second position between the first position and the closed position that includes the closed position.

Abstract: In general terms the present invention proposes a nozzle holder for securing a nozzle in an inhalation device, for example such as a soft mist inhaler (SMI), the nozzle holder being obtained or obtainable by metal injection moulding (MIM). Also disclosed is an inhalation device comprising the nozzle holder.

Abstract: In general terms the present invention proposes a nozzle fixing assembly 100 for an inhalation device 10. The nozzle fixing assembly 100 comprises a nozzle 110 enclosed between a nozzle holder 122 and a chamber body 150. The nozzle holder 122 provides a holder abutment surface 129 which abuts at least a portion of an abutment surface 152 of the chamber body 150 to define an abutting interface 170. A nozzle seal 180 is arranged annularly around at least a portion of the nozzle 110 and extends between the nozzle 110 and the nozzle holder 122 and between the nozzle 110 and the chamber body 150 such that the nozzle seal 180 makes sealing contact with the nozzle holder 122 and chamber body 150 and provides a perimetral line of sealing at the abutting interface 170.

Abstract: In general terms the present invention proposes a nozzle arrangement 100 for delivering a liquid from a liquid delivery device. The nozzle arrangement 100 comprises a nozzle 102 having an inlet side 104 for receiving a liquid to be delivered and an outlet side 106 for delivering the liquid. The nozzle arrangement 100 also comprises a fixing device 120 for fixing the nozzle 102 in the delivery device and a recess 130 located at the outlet side 106 of the nozzle 102. The recess is 130 arranged to wick away liquid deposited on the nozzle 102 and/or fixing device 120.

Abstract: In general terms the present invention proposes a manifold 100 for delivery of medicament powder from a dispenser device. The manifold 100 comprises a first chamber 102 comprising a first chamber inlet 102A and a first chamber outlet 102B. The first chamber 102 is arranged to direct a first flow of air 110 from the first chamber inlet 102A to the first chamber outlet 102B. The manifold 100 also comprises a conduit 104 having a conduit inlet 104A and a conduit outlet 104B. The first chamber outlet 102B and conduit inlet 104A are arranged such that when a supply of medicament powder is positioned proximal thereto the first flow of air 110 is directed from the first chamber outlet 102B to the conduit inlet 104A via the supply of medicament powder to entrain the medicament powder and provide a flow of air entrained with medicament powder through the conduit 104.