Patents by Inventor Adam T. Hoye

Adam T. Hoye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GRANZYME B DIRECTED IMAGING AND THERAPY
    Publication number: 20240390530
    Abstract: Compounds of Formula (I) and Formula (II), which are capable of binding to granzyme B. Also provided herein are pharmaceutical compositions comprising such for use in, for example, imaging Granzyme B and/or treating immunoregulatory abnormalities.
    Type: Application
    Filed: June 9, 2021
    Publication date: November 28, 2024
    Applicant: CytoSite Biopharma Inc.
    Inventors: Julia Marie CLAY, Hui XIONG, Kevin Michael RULEY, Francisco A. VALENZUELA, Adam T. HOYE, Mark A. CASTANARES, James KRONAUGE
  • GRANZYME B DIRECTED IMAGING AND THERAPY
    Publication number: 20240165278
    Abstract: Compounds of Formula (I) and Formula (II), which are capable of binding to granzyme B. Also provided herein are pharmaceutical compositions comprising such for use in, for example, imaging Granzyme B and/or treating immunoregulatory abnormalities.
    Type: Application
    Filed: June 9, 2021
    Publication date: May 23, 2024
    Applicant: CytoSite Biopharma Inc.
    Inventors: Julia Marie CLAY, Hui XIONG, Kevin Michael RULEY, Francisco A. VALENZUELA, Adam T. HOYE, Mark A. CASTANARES, James KRONAUGE
  • Silicon-based cross coupling agents and methods of their use
    Patent number: 9850261
    Abstract: Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: December 26, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Adam T. Hoye, Won-Suk Kim, Dionicio Martinez-Solorio, Amos B. Smith, III, Rongbiao Tong, Minh Huu Nguyen, Luis Sanchez, Bruno Nicolas Melillo
  • SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE
    Publication number: 20170210766
    Abstract: Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.
    Type: Application
    Filed: July 16, 2015
    Publication date: July 27, 2017
    Inventors: Adam T. HOYE, Won-Suk KIM, Dionicio MARTINEZ-SOLORIO, Amos B. SMITH, Rongbiao TONG, Minh Huu NGUYEN, Luis SANCHEZ, Bruno Nicolas MELILLO
  • HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES
    Publication number: 20170173016
    Abstract: The present invention is directed to triazolopyrimidine, phenylpyrimidine, pyridopyridazine, and pyridotriazine compounds and their use in the treatment of neurodegenerative disorders.
    Type: Application
    Filed: March 7, 2017
    Publication date: June 22, 2017
    Inventors: Carlo Ballatore, Kurt R. Brunden, Adam T. Hoye, Virginia M.Y. Lee, Amos B. Smith, III, John Q. Trojanowski
  • Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
    Patent number: 9649317
    Abstract: The present invention is directed to triazolopyrimidine, phenylpyrimidine, pyridopyridazine, and pyridotriazine compounds which are microtubule-stabilizing compounds and their use in the treatment of neurodegenerative disorders, in particular, tauopathies, such as for example, Alzheimer's disease, frontotemporal lobar degeneration, Pick's disease, progressive supranuclear palsy (PSP), and corticobasal degeneration. In addition, the compounds of the invention may be useful for other diseases where tau pathology is a comorbidity or where microtubule function is compromised, for example, schizophrenia, Parkinson's disease (PD), PD with dementia, Lewy body disease with dementia, and amyotrophic lateral sclerosis.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: May 16, 2017
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Carlo Ballatore, Kurt R. Brunden, Adam T. Hoye, Virginia M. Y. Lee, Amos B. Smith, John Q. Trojanowski
  • Irciniastatin analogues
    Patent number: 9540355
    Abstract: The present invention is directed to irciniastatin analogs. Uses of these analogs also described.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: January 10, 2017
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Amos B. Smith, III, Chihui An, Adam T. Hoye
  • Silicon-based cross coupling agents and methods of their use
    Patent number: 9499660
    Abstract: Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: November 22, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Adam T. Hoye, Won-suk Kim, Dionicio Martinez-Solorio, Amos B. Smith, III, Luis Sanchez, Rongbiao Tong, Minh Huu Nguyen, Bruno Melillo
  • IRCINIASTATIN ANALOGUES
    Publication number: 20150344462
    Abstract: The present invention is directed to irciniastatin analogues. Uses of these analogues also described.
    Type: Application
    Filed: January 15, 2014
    Publication date: December 3, 2015
    Inventors: Amos B. Smith, III, Chihui AN, Adam T. Hoye
  • HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES
    Publication number: 20150224105
    Abstract: The present invention is directed to triazolopyrimidine, phenylpyrimidine, pyridopyridazine, and pyridotriazine compounds which are microtubule-stabilizing compounds and their use in the treatment of neurodegenerative disorders, in particular, tauopathies, such as for example, Alzheimer's disease, frontotemporal lobar degeneration, Pick's disease, progressive supranuclear palsy (PSP), and corticobasal degeneration. In addition, the compounds of the invention may be useful for other diseases where tau pathology is a comorbidity or where microtubule function is compromised, for example, schizophrenia, Parkinson's disease (PD), PD with dementia, Lewy body disease with dementia, and amyotrophic lateral sclerosis.
    Type: Application
    Filed: September 19, 2013
    Publication date: August 13, 2015
    Inventors: Carlo Ballatore, Kurt R. Brunden, Adam T. Hoye, Virginia M.Y. Lee, Amos B. Smith, John Q. Trojanowski
  • SILICON-BASED CROSS COUPLING AGENTS AND METHODS OF THEIR USE
    Publication number: 20150152216
    Abstract: Compositions and methods using silicon-based cross-coupling agents in the formation of carbon-carbon and carbon-nitrogen bonds are described.
    Type: Application
    Filed: June 7, 2013
    Publication date: June 4, 2015
    Inventors: Adam T. Hoye, Won-suk Kim, Dionicio Martinez-Solorio, Amos B. Smith, III, Luis Sanchez, Rongbiao Tong, Minh Huu Nguyen