Abstract: The present disclosure is directed to compounds of formulas (I)-(VI), which are useful as modulators of USP19. The compounds are further useful in the inhibition of USP19 and the treatment of diseases or disorders associated with the inhibition of USP19. For instance, the disclosure is concerned with compounds and compositions for inhibition of USP19 and methods of treating diseases associated with the inhibition of USP19 (e.g., Parkinson's disease, Ewing sarcoma, and other metabolic diseases including muscle wasting and diabetes).

Abstract: This product provides an extremely uncomplicated, high quality, physics-based lockdown device at an affordable price, even for facilities on a limited budget. This device is one of three different products that were primarily conceived for use in schools, and other public facilities, where multiple types of doorways are used and overall cost is a major factor. Unfortunately, the state of certain societal conditions now dictates that such extreme security measures are not only necessary, but that it will most likely soon be mandatory for these facilities to obtain some form of security device to lock down the facility in the event of an armed intruder. This is such a device.