Patents by Inventor Adam VINCEK

Adam VINCEK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anc80 encoding sphingolipid-metabolizing proteins for mitigating disease-induced tissue damage
    Patent number: 11618893
    Abstract: The present disclosure relates generally to the use of sphingolipid-metabolizing proteins to mitigate or minimize tissue damage resulting from injury or from disease, for example, pulmonary arterial hypertension (PAH) when the sphingolipid-metabolizing protein is delivered via expression from an Anc80 vector.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: April 4, 2023
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Efrat Eliyahu, Adam Vincek, Anthony Fargnoli, Michael Katz
  • ANC80 ENCODING SPHINGOLIPID-METABOLIZING PROTEINS FOR MITIGATING DISEASE-INDUCED TISSUE DAMAGE
    Publication number: 20220347276
    Abstract: The present disclosure relates generally to the use of sphingolipid-metabolizing proteins to mitigate or minimize tissue damage resulting from injury or from disease, for example, pulmonary arterial hypertension (PAH) when the sphingolipid-metabolizing protein is delivered via expression from an Anc80 vector.
    Type: Application
    Filed: September 11, 2019
    Publication date: November 3, 2022
    Inventors: Efrat ELIYAHU, Adam VINCEK, Anthony FARGNOLI, Michael KATZ
  • ANC80 ENCODING SPHINGOLIPID-METABOLIZING PROTEINS
    Publication number: 20210244827
    Abstract: The present disclosure pertains to the use of an Anc80 viral vector that encodes a sphingolipid-metabolizing protein such as acid ceramidase to achieve expression of the sphingolipid-metabolizing protein in a mammalian cell or group of cells. Expression of the protein from the Anc80 vector reduces high levels of ceramide in the cell that lead to cell death or senescence.
    Type: Application
    Filed: March 7, 2019
    Publication date: August 12, 2021
    Inventors: Efrat ELIYAHU, Adam VINCEK, Michael KATZ
  • SPHINGOLIPID-METABOLIZING PROTEINS ENHANCE THE EFFICIENCY OF GENE EDITING IN CELLS
    Publication number: 20210002668
    Abstract: The present disclosure pertains to the use of a modified RNA (modRNA) that encodes a sphingolipid-metabolizing protein such as acid ceramidase to achieve expression of the sphingolipid-metabolizing protein in a mammalian cell or group of cells. Expression of the protein from the (modRNA) reduces high levels of ceramide in the cell that lead to cell death or senescence.
    Type: Application
    Filed: March 7, 2019
    Publication date: January 7, 2021
    Inventors: Efrat ELIYAHU, Lior ZANGI, Adam VINCEK, Yoav HADAS
  • MODRNA ENCODING SPHINGOLIPID-METABOLIZING PROTEINS
    Publication number: 20210000975
    Abstract: The present disclosure pertains to the use of a modified RNA (modRNA) that encodes a sphingolipid-metabolizing protein such as acid ceramidase to achieve expression of the sphingolipid-metabolizing protein in a mammalian cell or group of cells. Expression of the protein from the (modRNA) reduces high levels of ceramide in the cell that lead to cell death or senescence.
    Type: Application
    Filed: March 7, 2019
    Publication date: January 7, 2021
    Inventors: Efrat ELIYAHU, Lior ZANGI, Adam VINCEK, Yoav HADAS
  • ANC80 ENCODING SPHINGOLIPID-METABOLIZING PROTEINS FOR MITIGATING DISEASE-INDUCED TISSUE DAMAGE
    Publication number: 20200002696
    Abstract: The present disclosure relates generally to the use of sphingolipid-metabolizing proteins to mitigate or minimize tissue damage resulting from injury or from disease, for example, pulmonary arterial hypertension (PAH) when the sphingolipid-metabolizing protein is delivered via expression from an Anc80 vector.
    Type: Application
    Filed: September 11, 2019
    Publication date: January 2, 2020
    Inventors: Efrat ELIYAHU, Adam VINCEK, Anthony FARAGNOLI, Misha KATZ
  • Cyclic vinylogous amides as bromodomain inhibitors
    Patent number: 10351511
    Abstract: Cyclic vinylogous amides of Formula I are disclosed The compounds are useful for treating diseases that arise from inappropriate activity of proteins containing an acetyl-lysine. The compositions comprise a genus of cyclic vinylogous amides that are inhibitors of bromodomain.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: July 16, 2019
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Ming-Ming Zhou, Michael Ohlmeyer, Adam Vincek, Nilesh Zaware
  • CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS
    Publication number: 20180105485
    Abstract: Cyclic vinylogous amides of Formula I are disclosed The compounds are useful for treating diseases that arise from inappropriate activity of proteins containing an acetyl-lysine. The compositions comprise a genus of cyclic vinylogous amides that are inhibitors of bromodomain.
    Type: Application
    Filed: December 14, 2017
    Publication date: April 19, 2018
    Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Ming-Ming ZHOU, Michael OHLMEYER, Adam VINCEK, Nilesh ZAWARE
  • Cyclic vinylogous amides as bromodomain inhibitors
    Patent number: 9884806
    Abstract: Cyclic vinylogous amides of Formula I are disclosed The compounds are useful for treating diseases that arise from inappropriate activity of proteins containing an acetyl-lysine. The compositions comprise a genus of cyclic vinylogous amides that are inhibitors of bromodomain.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: February 6, 2018
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Ming-Ming Zhou, Michael Ohlmeyer, Adam Vincek, Nilesh Zaware
  • CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS
    Publication number: 20160200666
    Abstract: Cyclic vinylogous amides of Formula I are disclosed The compounds are useful for treating diseases that arise from inappropriate activity of proteins containing an acetyl-lysine. The compositions comprise a genus of cyclic vinylogous amides that are inhibitors of bromodomain.
    Type: Application
    Filed: August 29, 2014
    Publication date: July 14, 2016
    Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Ming-Ming ZHOU, Michael OHLMEYER, Adam VINCEK, Nilesh ZAWARE