Abstract: The invention relates to a kit comprising at least a first composition and a second composition, each said first and second compositions comprising at least one epitope of a liver disease antigen, wherein said epitope is a CD8+T cell epitope, for use in induction of an immune response in the liver of a mammalian subject by administration of said first composition by intramuscular (i.m.), subcutaneous (s.c.), intradermal (i.d.) or aerosol route, and administration of said second composition by intravenous (i.v.) or subcutaneous (s.c.) route, characterised in that said first and second compositions are administered by different routes. The invention also relates to uses, methods and treatments.

Abstract: A system includes a query response engine that identifies first and second query responses. The engine stores the first query response in a locked configuration and the second query response in a configuration that enables the stored second query response to be modified. The query engine generates query response data associated with the first query response or the second query response. The system includes a connection assessor that determines a connection variable by assessing a network connection and determines whether a transmission condition is satisfied based on the connection variable. The system includes a query response transmitter that, when it is determined that the transmission condition is satisfied, transmits the query response data from the query response transmitter of the system to another device.

Abstract: A sample collection and processing apparatus includes a tissue processing cassette and a biopsy device. The tissue processing cassette is sized to be used in a pathology laboratory for purposes of dehydrating, embedding and sectioning. The tissue processing cassette has at least one distal opening through which tissue samples are received and has a floor with a plurality of openings. The biopsy device has a cassette holder adapted to receive the tissue processing cassette. The cassette holder has a fluid path adapted to be coupled to a vacuum source and in fluid communication with the interior of the tissue processing cassette through the openings of the floor such that vacuum from the vacuum source facilitates the transfer of the cut tissue samples into the received tissue processing cassette.

Abstract: The invention relates to a kit comprising at least a first composition and a second composition, each said first and second compositions comprising at least one epitope of a liver disease antigen, wherein said epitope is a CD8+T cell epitope, for use in induction of an immune response in the liver of a mammalian subject by administration of said first composition by intramuscular (i.m.), subcutaneous (s.c.), intradermal (i.d.) or aerosol route, and administration of said second composition by intravenous (i.v.) or subcutaneous (s.c.) route, characterised in that said first and second compositions are administered by different routes. The invention also relates to uses, methods and treatments.

Abstract: A highly tunable bioscaffold is provided, as well as a method of manufacture of the bioscaffold and methods of use of the bioscaffold, for example for drug testing, cell propagation and for optimizing growth of a cell type, for example corneal endothelial cells.

Abstract: Embodiments relate to systems and methods for electronically conditioning transmission of communications based on results of a connection assessment. An electronic file is executed at an electronic device, which causes a first query and a second query to be presented. A first query response and a second query response are identified. The first query response is stored in a locked configuration that inhibits the ability to modify the first query response to the first query. The second query response is stored but is not stored in the locked configuration. Query response data is generated that includes an identifier of the second query, an identifier of the second query response and an identifier of the electronic device. A connection variable is determined by assessing one or more network connections available to the electronic device. When a transmission condition is satisfied, the query response data is transmitted to another device.

Abstract: An anti-aliasing photodetector system for a powered ophthalmic device, such as a contact lens, may be utilized for any number of functions. The anti-aliasing photodetector system converts current from an array of photodetectors into a voltage for use in other aspects of the powered ophthalmic device. The anti-aliasing photodetector system comprises a photodiode array including a plurality of individual photodiodes, an integrate-and-hold circuit, including a capacitor and switch to convert current to voltage, and an analog-to-digital converter. The anti-aliasing photodetector system provides for low power consumption, a wide dynamic range, noise rejection, and is capable of detecting incident ambient visible light as well as incident infrared light.

Abstract: A method of obtaining and analyzing at least one tissue sample includes forming, in a tissue container, first tracking data associated with the at least one tissue sample. Second tracking data is formed, in a transport container. The second tracking data is associated with the at least one tissue sample. The at least one tissue sample is placed in the tissue container. The first and second tracking data from the tissue container and the transport container are scanned with an electronic scanning system to ensure that the first and second tracking data are both associated with the removed tissue sample.

Abstract: An electrically-heated clothing/pants and its accessories, and the electric heating component in the electrically-heated clothing/pants and its accessories is an infrared laminate electric heating component, and the infrared laminate electric heating component is consisting of a conducting element and an infrared laminate.

Abstract: An anti-aliasing photodetector system for a powered ophthalmic device, such as a contact lens, may be utilized for any number of functions. The anti-aliasing photodetector system converts current from an array of photodetectors into a voltage for use in other aspects of the powered ophthalmic device. The anti-aliasing photodetector system comprises a photodiode array including a plurality of individual photodiodes, an integrate-and-hold circuit, including a capacitor and switch to convert current to voltage, and an analog-to-digital converter. The anti-aliasing photodetector system provides for low power consumption, a wide dynamic range, noise rejection, and is capable of detecting incident ambient visible light as well as incident infrared light.

Abstract: A position monitoring system comprises a fiducial reference, a tracker for obtaining image information of surgical site, and a computer system with processor, memory, a software program, and access to a database with scan data of the surgical site with the fiducial reference fixed to the site. Uniquely identifiable tracking markers are fixed to the fiducial reference and to a surgical implement. The computer determines the relative positions and orientations of the markers based on live image information from the tracker, relates and displays on one or more display systems the current position and orientation of the fiducial reference and the surgical implement. The computer renders on the one or more display systems a surgical guidance graphic user interface showing planned and actual locations for the surgical implement to impinge on the area of surgical patient, an allowed range of angles of incidence for the surgical implement, and an actual instantaneous angle of incidence of the surgical implement.

Abstract: Embodiments relate to electronic administration of an academic examination. Execution of an exam file on a student device causes exam questions to be presented. Input from students is translated into responses. Response data identifying one or more responses and a student identifier may be transmitted from the student user device to another device during an exam period or at the end of the exam period. However, the transmission may be explicitly or functionally conditioned by network connection strength, network availability and so forth. When the condition is not satisfied or when a transmission fails, response data is locally and securely cached at the student user device. The response(s) is immediately locked or locked at the end of an examination period, such that a student user can no longer modify the response(s). The student user device subsequently transmits the response data (e.g., when the transmission condition is satisfied).

Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.

Abstract: A highly tunable bioscaffold is provided, as well as a method of manufacture of the bioscaffold and methods of use of the bioscaffold, for example for drug testing, cell propagation and for optimizing growth of a cell type, for example corneal endothelial cells.

Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.

Abstract: A method is provided for calibrating Amplitude Modulation to Phase Modulation (AM/PM) predistortion coefficients for a polynomial used to compensate for AM/PM distortion of a power amplifier in the transmit chain of a mobile terminal. In general, the power amplifier is controlled by a variable supply voltage, which is generated based on an adjustable power control signal. After the power amplifier is placed in the mobile terminal, a predetermined data pattern is transmitted in a transmit burst. During the transmit burst, the variable supply voltage is changed from a first value to a second value, and a resultant phase shift in the radio frequency output signal provided by the mobile terminal is measured. Based on the phase shift, one of numerous predetermined sets of AM/PM predistortion coefficients is selected as the AM/PM coefficients for the mobile terminal.