Abstract: The invention relates to a kit comprising at least a first composition and a second composition, each said first and second compositions comprising at least one epitope of a liver disease antigen, wherein said epitope is a CD8+T cell epitope, for use in induction of an immune response in the liver of a mammalian subject by administration of said first composition by intramuscular (i.m.), subcutaneous (s.c.), intradermal (i.d.) or aerosol route, and administration of said second composition by intravenous (i.v.) or subcutaneous (s.c.) route, characterised in that said first and second compositions are administered by different routes. The invention also relates to uses, methods and treatments.

Abstract: A position monitoring system comprises a fiducial reference, a tracker for obtaining image information of surgical site, and a computer system with processor, memory, a software program, and access to a database with scan data of the surgical site with the fiducial reference fixed to the site. Uniquely identifiable tracking markers are fixed to the fiducial reference and to a surgical implement. The computer determines the relative positions and orientations of the markers based on live image information from the tracker, relates and displays on one or more display systems the current position and orientation of the fiducial reference and the surgical implement. The computer renders on the one or more display systems a surgical guidance graphic user interface showing planned and actual locations for the surgical implement to impinge on the area of surgical patient, an allowed range of angles of incidence for the surgical implement, and an actual instantaneous angle of incidence of the surgical implement.