Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.

Abstract: This application describes systems and methods for generating machine learning models (MLMs). An exemplary method includes obtaining a sample and user input data characterizing a product or service. A subset of the data is selected from the sample based on sampling the sample according to the user input data. An MLM is trained by applying the data subset as training input to the MLM, thereby providing a trained MLM to emulate a customer selection process unique to the product or service. A user interface (UI) configured to receive other user input data and cause the trained MLM to execute on the other user input data, thereby testing the trained MLM, is presented. A summary of results from the execution of the trained MLM is generated and presented in the UI. The summary of results indicates a contribution to the trained MLM of each of a plurality of features.

Abstract: A extended reality communication system, methods, apparatus, and computer program product are disclosed. The communication system provides for remote real-time communication between a proctor and an operator, where the operator is performing tasks on a local work object, such as a patient. The system incorporates a combination of haptic, virtual keyboard, VR, XR, and audio inputs to provide communication of instructions between the proctor and the operator that are projected as a holographic image in a field of view on the patient. The system includes a proctor station and an operator station communicatively coupled with one or more servers.

Abstract: An optical sensing module suitable for wearable devices, the optical sensing module comprising: a silicon or silicon nitride transmitter photonic integrated circuit (PIC), the transmitter PIC comprising: a plurality of lasers, each laser of the plurality of lasers operating at a wavelength that is different from the wavelength of the others; an optical manipulation region, the optical manipulation region comprising one or more of: an optical modulator, optical multiplexer (MUX); and additional optical manipulation elements; and one or more optical outputs for light originating from the plurality of lasers.

Abstract: A patient interface system for delivery of respiratory therapy to a patient comprises: a nasal portion including a nasal chamber and a nasal sealing portion adapted to form a seal with the patients including an opening; an inlet conduit connected to the nasal portion to deliver the pressurized, breathable gas to the nasal chamber; and a nasal chamber coupling component adapted to form part of a releasable fluid coupling to enable the nasal portion to be fluidly coupled to a mouth portion to communicate a portion of the pressurized, breathable gas through the nasal chamber opening to the mouth portion.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Human Respiratory Syncytial Virus (HRSV) or Human Metapneumovirus (HMPV) inhibitors. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HRSV or HMPV infection. The invention also relates to methods of treating an HRSV or HMPV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to bone morphogenetic protein-9 (BMP9) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Abstract: Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.

Abstract: Embodiments of the present disclosure relate to storage processor and storage system. A storage processor comprises a housing provided with a cover and a main power supply input, which, for example, connects an external power source to supply power to the storage processor. A battery is disposed within the housing and configured to continue supplying power to the storage processor in response to the main power supply input being cut off. A protection device is disposed within the housing and configured to disable the battery to supply power to the storage processor in response to determining that the cover is opened.

Abstract: Embodiments of the disclosure provide a method, a computer [program product and apparatus for a soft-switch in a storage system, by setting data in a source of the soft-switch to be read-only and starting a replication process of the data to a destination of the soft-switch in response to a soft-switch request; recording at the source an update operation for the data during the replication process and synchronously recording the update operation into the destination; updating the replicated data at the destination with the synchronously recorded update operation in response to the completion of the replication process; and disabling a data access to the source and enabling a data access to the destination.

Abstract: Embodiments of the present disclosure relate to storage processor and storage system. A storage processor comprises a housing provided with a cover and a main power supply input, which, for example, connects an external power source to supply power to the storage processor. A battery is disposed within the housing and configured to continue supplying power to the storage processor in response to the main power supply input being cut off. A protection device is disposed within the housing and configured to disable the battery to supply power to the storage processor in response to determining that the cover is opened.

Abstract: Embodiments of the disclosure provide a method, a computer [program product and apparatus for a soft-switch in a storage system, by setting data in a source of the soft-switch to be read-only and starting a replication process of the data to a destination of the soft-switch in response to a soft-switch request; recording at the source an update operation for the data during the replication process and synchronously recording the update operation into the destination; updating the replicated data at the destination with the synchronously recorded update operation in response to the completion of the replication process; and disabling a data access to the source and enabling a data access to the destination.

Abstract: A machine for cleaning a window is provided which may comprise a chassis, window cleaning apparatus or mechanism, and a makeweight wherein the makeweight counterbalances the weight of the window cleaning apparatus by traversing the chassis in the first and second directions as the cleaning apparatus traverses the chassis in the second and first directions, respectively.