Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.

Abstract: An instant color movie screen providing the screening of black and white films to have the appearance of color and also to enhance the color images of color movies, the screen consisting of a flexible soft backed vinyl sheeting wound about a spring loaded roller supported on an adjustable tripod stand and with the sheeting having a multitude of orange colored highly reflective glass or plastic beads affixed to the screen face thereof. A modified embodiment provides for a series of high intensity orange colored lights mounted above the screen to provide orange highlights on a conventional white colored screening to provide black and white films with the appearance of color as well as to enhance the color images of color films projected onto the screen.