Abstract: The present invention relates to methods of screening the efficacy and safety of candidate therapies/immunotherapies/cell therapies using cells containing a first and optionally a second inducible system operable to express a first and optionally a second protein of interest to the desired levels. The invention further relates to inducible systems, especially to one or more chemically induced proximity systems comprising a first plant hormone inducible proximity system and a second plant hormone inducible proximity system, and to methods of controlling the expression of proteins of interest using the systems. The invention further relates to a method of making a cell comprising the systems, and to cells comprising the system.

Abstract: The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta T cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a transmembrane domain, a costimulatory signalling domain with the inclusion or not of a CD3 zeta signalling domain. Expression of CAR sequence omitting the CD3 zeta signalling domain in gamma delta T cells, provides for a CAR-T therapy in vivo, which will effect cytolysis only on target cells providing ligands for activation of the gamma delta T cell receptor (TCR).

Abstract: A method of preparing and using gamma delta T cells in the allogeneic or autologous treatment of subjects suffering from virus infection, fungal infection, protozoal infection and cancer.

Abstract: The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta T cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a transmembrane domain, a costimulatory signalling domain with the inclusion or not of a CD3 zeta signalling domain. Expression of CAR sequence omitting the CD3 zeta signalling domain in gamma delta T cells, provides for a CAR-T therapy in vivo, which will effect cytolysis only on target cells providing ligands for activation of the gamma delta T cell receptor (TCR).

Abstract: A modified T cell is described which is adapted to overexpress SLC1A5, an isoform of SLC1A5 or an alternative tryptophan or glutamine transporter. Further described is the use of such modified T cells in the treatment of disease, in particular cancer, methods to select modified T cells which overexpress SLC1A5 and nucleic acids and vectors to provide for such modified T cells.

Abstract: The present invention provides composition and methods for the treatment of cancer or infectious diseases in a human. The invention includes the generation and administration of gamma delta T cells that express chimeric antigen receptors (CARs) comprising an antigen binding domain, a hinge domain, a transmembrane domain, a costimulatory signalling domain with the inclusion or not of a CD3 zeta signalling domain. Expression of CAR sequence omitting the CD3 zeta signalling domain in gamma delta T cells, provides for a CAR-T therapy in vivo, which will effect cytolysis only on target cells providing ligands for activation of the gamma delta T cell receptor (TCR).

Abstract: A method of preparing and using gamma delta T cells in the allogeneic or autologous treatment of subjects suffering from virus infection, fungal infection, protozoal infection and cancer.