Patents by Inventor Adeline Gadzinski

Adeline Gadzinski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Subject-specific tumor inhibiting cells and the use thereof
    Patent number: 11766455
    Abstract: This disclosure is directed to a pharmaceutical composition comprises tumor inhibiting cells (TICs) and a method for producing the TICs. The tumor inhibiting cells can be derived from immune cells including T cells, NK cells, or a combination thereof, modified to have inactivated Cbl-b gene alleles and free from Cbl-b bio-function (Cbl-b?/? TICs). The Cbl-b?/? TICs are free from deoxyribonucleic acids exogenous to the immune cells. The immune cells can be isolated using a portable cell isolation and modification device. This disclosure is further directed to a method for treating tumorous conditions in subjects. The pharmaceutical composition can provide a subject-specific tumor treatment.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: September 26, 2023
    Assignees: EZY Biotech LLC, Adaerata, Limited Patnership
    Inventors: Hua Gu, Gang G Xu, Adeline Gadzinski, Haijun Tong
  • Subject-Specific Tumor Inhibiting Cells and the Use Thereof
    Publication number: 20200390810
    Abstract: This disclosure is directed to a pharmaceutical composition comprises tumor inhibiting cells (TICs) and a method for producing the TICs. The tumor inhibiting cells can be derived from immune cells including T cells, NK cells, or a combination thereof, modified to have inactivated Cbl-b gene alleles and free from Cbl-b bio-function (Cbl-b?/? TICs). The Cbl-b?/? TICs are free from deoxyribonucleic acids exogenous to the immune cells. The immune cells can be isolated using a portable cell isolation and modification device. This disclosure is further directed to a method for treating tumorous conditions in subjects. The pharmaceutical composition can provide a subject-specific tumor treatment.
    Type: Application
    Filed: December 14, 2018
    Publication date: December 17, 2020
    Inventors: HUA GU, Gang G Xu, Adeline Gadzinski, Haijun Tong
  • Molecular Complex for Targeting Antigens Towards Cells Comprising Antigens and Uses Thereof for Vaccination
    Publication number: 20190322731
    Abstract: The invention relates to a molecular complex for targeting the antigen towards cells comprising antigens, including at least one antigen associated with at least two ligands of surface molecules of cells comprising antigens, said complex including at least one first ligand of a sulphated sugar of the glycosaminoglycan family and a second ligand of a specific surface molecule of cells comprising antigens, and said first ligand being covalently bonded with said antigen and/or said second ligand.
    Type: Application
    Filed: July 3, 2019
    Publication date: October 24, 2019
    Applicant: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Michel Leonetti, Alexandra Savatier, Adeline Gadzinski, Jean-Claude Boulain
  • Molecular complex for targeting antigens towards cells comprising antigens and uses thereof for vaccination
    Patent number: 10385120
    Abstract: The invention relates to a molecular complex for targeting the antigen towards cells comprising antigens, including at least one antigen associated with at least two ligands of surface molecules of cells comprising antigens, said complex including at least one first ligand of a sulphated sugar of the glycosaminoglycan family and a second ligand of a specific surface molecule of cells comprising antigens, and said first ligand being covalently bonded with said antigen and/or said second ligand.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: August 20, 2019
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Michel Leonetti, Alexandra Savatier, Adeline Gadzinski, Jean-Claude Boulain
  • Molecular Complex for Targeting Antigens Towards Cells Comprising Antigens and Uses Thereof for Vaccination
    Publication number: 20130195908
    Abstract: The invention relates to a molecular complex for targeting the antigen towards cells comprising antigens, including at least one antigen associated with at least two ligands of surface molecules of cells comprising antigens, said complex including at least one first ligand of a sulphated sugar of the glycosaminoglycan family and a second ligand of a specific surface molecule of cells comprising antigens, and said first ligand being covalently bonded with said antigen and/or said second ligand.
    Type: Application
    Filed: February 1, 2011
    Publication date: August 1, 2013
    Inventors: Michel Leonetti, Alexandra Savatier, Adeline Gadzinski, Jean-Claude Boulain