Abstract: A method for preventing neutropenia or reducing the duration of neutropenia in a patient by administering therapeutically effective amount of a human hybrid (hy) Fc fused granulocyte colony stimulating factor (G-CSF) developed as next-generation G-CSF.

Abstract: A formulation including a stable lyophilized formulation prepared by lyophilizing an aqueous preparation and the lyophilized composition is reconstituted before use is disclosed. The formulation is suitable for administration via a subcutaneous (SC) route and contains an Fc fused to granulocyte colony stimulating factor (G-CSF) molecules via peptide bond. The formulation also contains a stabilizer, surfactant, and buffer, at pH value of the formulation that is between 3.8 and 5.2.

Abstract: A stable form of hybrid Fc fused Granulocyte Colony Stimulating Factor (G-CSF) formulation is disclosed. The formulation includes (i) a therapeutically effective amount of hybrid Fc fusion G-CSF, (ii) a buffer system, (iii) at least one stabilizer and (iv) at least one surfactant, and (v) optionally propylene glycol as organic solvent, suitable for administration via a subcutaneous (SC) route.

Abstract: A method for preventing neutropenia or reducing the duration of neutropenia in a patient by administering therapeutically effective amount of a human hybrid (hy) Fc fused granulocyte colony stimulating factor (G-CSF) developed as next-generation G-CSF.

Abstract: A lock system which is included in shotguns that are used by hunters to hunt game animals, characterized in that it is developed to provide safety storage by disassembling the trigger group from the case when the gun is not used and to provide the trigger group to be easily mounted on the case when the gun is used. This provides easy assembly and disassembly procedures of the trigger group on the case via a lock bolt gap, a contact surface and a locking point created on the case belonging to the gun. A stop gap, fitting surface, lock bolt gap, vertical surface, assembly gap, positioning gap and operating gap are created on the trigger guard of the trigger group. A lock bolt contacted with a cap pin extends through the assembly gap by positioning in the lock bolt gap created on the trigger group.

Abstract: A lock system which is included in shotguns that are used by hunters to hunt game animals, characterized in that it is developed to provide safety storage by disassembling the trigger group through the case when the gun is not used and to provide the trigger group to be easily mounted on the case when the gun is used. This provides easy assembly and disassembly procedures of the trigger group on the case via a latch clearance, a contact surface and a locking clearance created on the case belonging to the gun. A pawl clearance, flange, lock clearance, vertical surface, mounting clearance, positioning clearance and running clearance are created on the rail of the trigger group. A lock bolt contacted with the cap pin got through the mounting clearance by positioning in the lock clearance created on the trigger group.

Abstract: The invention pertains to the rotating head (20) found in the bolt action assembly (A) of the gas-operated, recoil-operated, or bolt action, or lever-action hunting shotguns and is characterized in that it pertains to a fixing shaft (13) with a fixing plane (14) formed at the end of the cam action groove (12) located on the body (10) of the bolt action (A), a spring shaft (22) formed on the rotating head (20) positioned within the passage hole (11) located in the body (10) of the bolt action (A), a mounting hole (23) formed in the spring shaft (22) on the rotating head (20) positioned within the passage hole (11) located in the body (10) of the bolt action (A), a rotation spring (30) with a mounting lug (31) located at one end and a fixing lug (32) at the other end.