Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

Abstract: A medical device may include a tubular sleeve configured for implantation in a body lumen, the sleeve having a first configuration with a first rigidity and a second configuration with a second rigidity greater than the first rigidity, the sleeve including: a flexible membrane defining an interior lumen; and a channel extending along the membrane.

Abstract: A medical device may include a tubular sleeve configured for implantation in a body lumen, the sleeve having a first configuration with a first rigidity and a second configuration with a second rigidity greater than the first rigidity, the sleeve including: a flexible membrane defining an interior lumen; and a channel extending along the membrane.

Abstract: A vascular occlusion device for deployment within a lumen of a vessel may include a self-expanding frame configured to shift between a collapsed configuration and an expanded configuration, the self-expanding frame defining a perimeter of an interior space disposed within the self-expanding frame, and an occlusive membrane secured to the self-expanding frame. The occlusive membrane may include a suspended portion disposed within the self-expanding frame and spaced apart from the perimeter of the interior space.

Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

Abstract: Embodiments herein relate to implantable medical devices including a fibrous cover layer. In an embodiment, an implantable medical device is included having a housing, an optical chemical sensing element disposed along the housing, and a fibrous electrospun cover layer, wherein the fibrous electrospun cover layer is disposed over the optical chemical sensing element. In another embodiment, a method of making an implantable medical device is included. The method can specifically include depositing an optical chemical sensing element into a sensor optical carrier attached to a housing and applying a fibrous electrospun cover layer over the optical chemical sensing element. Other embodiments are also included herein.

Abstract: Embodiments herein relate to chemical sensing elements including a rolled multilayer structure. In a first aspect, a method of making a chemical sensor element is included, the method including depositing a polymer layer onto a deposition substrate, infusing a chemical sensor composition into the polymer layer, applying a hydrogel layer over the polymer layer to form a multilayer film, rolling the multilayer film down the deposition substrate, and slicing the multilayer film to form the chemical sensor element. Other embodiments are also included herein.

Abstract: A method of making a solution including poly(ethylene terephthalate). The method includes dissolving poly(ethylene terephthalate) in a solvent mixture to form a solution, the solvent mixture including two solvent components. A Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa0.5, a polar HSP of 5.56 MPa0.5, and a hydrogen bonding HSP of 14.27 MPa0.5 is less than about 2 MPa0.5.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for applying ablation therapy to a tissue region. The apparatuses, systems, and methods may include a balloon structure and one or more electrodes arranged on or within the balloon structure and configured to deliver energy to the tissue region.

Abstract: A method of making a solution including poly(ethylene terephthalate). The method includes dissolving poly(ethylene terephthalate) in a solvent mixture to form a solution, the solvent mixture including two solvent components. A Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa0.5, a polar HSP of 5.56 MPa0.5, and a hydrogen bonding HSP of 14.27 MPa0.5 is less than about 2 MPa0.5.

Abstract: A vascular occlusion device for deployment within a lumen of a vessel may include a self-expanding frame configured to shift between a collapsed configuration and an expanded configuration, the self-expanding frame defining a perimeter of an interior space disposed within the self-expanding frame, and an occlusive membrane secured to the self-expanding frame. The occlusive membrane may include a suspended portion disposed within the self-expanding frame and spaced apart from the perimeter of the interior space.

Abstract: An implantable drug eluting medical device includes a polymer substrate having a surface, a first plurality of nanofibers, and at least one antimicrobial drug. Each of the first plurality of nanofibers includes a first portion interpenetrated with the surface of the substrate to mechanically fix the nanofiber to the substrate, and a second portion projecting from the surface. The at least one antimicrobial drug is disposed within or among the second portion of the first plurality of nanofibers.

Abstract: A method of making a solution including poly(ethylene terephthalate). The method includes dissolving poly(ethylene terephthalate) in a solvent mixture to form a solution, the solvent mixture including two solvent components. A Hansen Solubility Parameter Distance between the solvent mixture and HSP coordinates having a dispersion HSP of 18.02 MPa0.5, a polar HSP of 5.56 MPa0.5, and a hydrogen bonding HSP of 14.27 MPa0.5 is less than about 2 MPa0.5.

Abstract: A method for making a device including a polyisobutylene-polyurethane block copolymer. The method includes polymerizing a polyisobutylene diol, a diisocyanate, and a chain extender within a solvent system to form a polyisobutylene-polyurethane block copolymer solution, depositing the polyisobutylene-polyurethane block copolymer solution onto at least a portion of the device, and evaporating the solvent system from the deposited polyisobutylene-polyurethane block copolymer solution.

Abstract: An implantable drug eluting medical device includes a polymer substrate having a surface, a first plurality of nanofibers, and at least one antimicrobial drug. Each of the first plurality of nanofibers includes a first portion interpenetrated with the surface of the substrate to mechanically fix the nanofiber to the substrate, and a second portion projecting from the surface. The at least one antimicrobial drug is disposed within or among the second portion of the first plurality of nanofibers.

Abstract: A medical device may include a tubular sleeve configured for implantation in a body lumen, the sleeve having a first configuration with a first rigidity and a second configuration with a second rigidity greater than the first rigidity, the sleeve including: a flexible membrane defining an interior lumen; and a channel extending along the membrane.

Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods for applying ablation therapy to a tissue region. The apparatuses, systems, and methods may include a balloon structure and one or more electrodes arranged on or within the balloon structure and configured to deliver energy to the tissue region.

Abstract: An implantable medical device includes a polymer substrate and at least one nanofiber. The polymer substrate includes a surface portion extending into the polymer substrate from a surface of the substrate. The at least one nanofiber includes a first portion and a second portion. The first portion is interpenetrated with the surface portion of the substrate, and mechanically fixed to the substrate. The second portion projects from the surface of the substrate.

Abstract: A medical electrical lead includes an insulative lead body extending from a distal region to a proximal region, a conductor disposed within the insulative lead body and extending from the proximal region to the distal region, an electrode disposed on the insulative lead body and in electrical contact with the conductor, and a fibrous matrix disposed on at least part of the electrode. The fibrous matrix includes fibers. The fibers include a polyvinylidene fluoride-based (PVDF-based) polymer and a crystal-modifying additive. The PVDF-based polymer includes an amorphous PVDF phase and a crystalline PVDF phase. The crystalline PVDF phase includes a beta form crystalline structure in an amount exceeding any other crystalline structure form in the crystalline PVDF phase.