Patents by Inventor Adham Bear

Adham Bear has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T-CELL RECEPTORS AND COMPOSITIONS THEREOF FOR TARGETING MUTANT RAS
    Publication number: 20260083847
    Abstract: The present invention provides compositions and methods of treating cancer associated with mutant RAS. In certain aspects, the present invention provides T-cell receptors that bind to specific mutant RAS peptide fragments in the context of specific HLA types. In certain aspects, the present invention provides multispecific (e.g., bispecific) antibodies comprising T-cell receptors that bind to specific mutant RAS peptide fragments in the context of specific HLA types.
    Type: Application
    Filed: September 13, 2023
    Publication date: March 26, 2026
    Inventors: Adham Bear, Beatriz Carreno, Gerald Linette, Robert Vonderheide
  • Compositions and methods for targeting mutant RAS
    Patent number: 12533409
    Abstract: This invention relates to compositions and methods of treating cancer associated with mutant RAS. In certain aspects, the invention relates to antigenic RAS peptide fragments and T-cell receptors that bind to specific mutant RAS peptide fragments in the context of specific HLA types.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: January 27, 2026
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Adham Bear, Robert Vonderheide, Gerald Linette, Beatriz Carreno
  • Compositions and Methods for Targeting Mutant RAS
    Publication number: 20220088190
    Abstract: This invention relates to compositions and methods of treating cancer associated with mutant RAS. In certain aspects, the invention relates to antigenic RAS peptide fragments and T-cell receptors that bind to specific mutant RAS peptide fragments in the context of specific HLA types.
    Type: Application
    Filed: January 24, 2020
    Publication date: March 24, 2022
    Inventors: Adham Bear, Robert Vonderheide, Gerald Linette, Beatriz Carreno