Patents by Inventor Adi Goldenzweig

Adi Goldenzweig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VARIANTS OF BETA-GLUCOCEREBROSIDASE FOR USE IN TREATING GAUCHER DISEASE
    Publication number: 20230132790
    Abstract: A genetically modified human beta-glucocerebrosidase (GCase) is disclosed. The genetically modified GCase comprising an amino acid sequence at least 85% identical to SEQ ID NO: 2; and comprising mutations at coordinates L34P, K224N/G, T369E and N370D, where the coordinates correspond to said SEQ ID NO: 2; and capable of catalyzing hydrolysis of a glycolipid glucosylceramide (GlcCer). Pharmaceutical compositions comprising the genetically modified GCase and therapeutic methods of using same are also disclosed.
    Type: Application
    Filed: March 29, 2021
    Publication date: May 4, 2023
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Anthony H. FUTERMAN, Israel SILMAN, Joel L. SUSSMAN, Sarel FLEISHMAN, Adi GOLDENZWEIG, Sarka POKORNA, Yaacov ASHANI, Olga KHERSONSKY
  • Isolated phosphotriesterase polypeptides, polynucleotides encoding same and uses thereof in treating or preventing organophosphate exposure associated damage
    Patent number: 10688330
    Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: June 23, 2020
    Assignees: Yeda Research and Development Co. Ltd., University of Washington
    Inventors: Dan S. Tawfik, Haim Leader, Yaacov Ashani, Izhack Cherny, Moshe Goldsmith, Per Jr. Greisen, Sagar D. Khare, Gustav Oberdorfer, David Baker, Sarel Fleishman, Adi Goldenzweig, Nidhi Aggarwal
  • STABLE PROTEINS AND METHODS FOR DESIGNING SAME
    Publication number: 20200058367
    Abstract: A method for designing and selecting a protein having a stabilized structure compared to a corresponding wild type protein, and proteins having at least six amino acid substitutions with respect to a corresponding wild type protein, designed for improved thermal stability, improved specific activity and/or improved expression levels, are provided herein.
    Type: Application
    Filed: November 4, 2019
    Publication date: February 20, 2020
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Sarel FLEISHMAN, Adi GOLDENZWEIG, Dan S. TAWFIK
  • THERMOSTABLE VARIANTS OF P. FALCIPARUM PFRH5 WHICH CAN BE PRODUCED IN BACTERIAL CELLS
    Publication number: 20190374629
    Abstract: There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising Reticulocyte-binding protein Homologue 5 (PfRH5) antigens. In particular, the invention provides modified PfRH5 antigens rationally designed to produce improved stability and expression profiles whilst maintaining immunogenicity.
    Type: Application
    Filed: September 7, 2017
    Publication date: December 12, 2019
    Inventors: Simon J. Draper, Ivan Campeotto, Matthew K. Higgins, Sarel Fleishman, Adi Goldenzweig
  • Stable proteins and methods for designing same
    Patent number: 10468119
    Abstract: A method for designing and selecting a protein having a stabilized structure compared to a corresponding wild type protein, and proteins having at least six amino acid substitutions with respect to a corresponding wild type protein, designed for improved thermal stability, improved specific activity and/or improved expression levels, are provided herein.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: November 5, 2019
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Sarel Fleishman, Adi Goldenzweig, Dan S. Tawfik
  • ISOLATED PHOSPHOTRIESTERASE POLYPEPTIDES, POLYNUCLEOTIDES ENCODING SAME AND USES THEREOF IN TREATING OR PREVENTING ORGANOPHOSPHATE EXPOSURE ASSOCIATED DAMAGE
    Publication number: 20190083836
    Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.
    Type: Application
    Filed: December 10, 2015
    Publication date: March 21, 2019
    Inventors: Dan S. TAWFIK, Haim LEADER, Yaacov ASHANI, Izhack CHERNY, Moshe GOLDSMITH, Per Jr. GRIESEN, Sagar D KHARE, Gustav Oberdorfer, David Baker, Sarel Fleishman, Adi Goldenzweig, Nidhi Aggarwal
  • STABLE PROTEINS AND METHODS FOR DESIGNING SAME
    Publication number: 20170032079
    Abstract: A method for designing and selecting a protein having a stabilized structure compared to a corresponding wild type protein, and proteins having at least six amino acid substitutions with respect to a corresponding wild type protein, designed for improved thermal stability, improved specific activity and/or improved expression levels, are provided herein.
    Type: Application
    Filed: September 8, 2016
    Publication date: February 2, 2017
    Inventors: Sarel FLEISHMAN, Adi Goldenzweig, Dan S. Tawfik