Patents by Inventor Adi KLINGER

Adi KLINGER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Somatostatin prodrugs
    Patent number: 11261215
    Abstract: The present invention provides prodrugs of somatostatin peptide and peptide analogs that are tissue permeable and oral bioavailable and enable activity of the somatostatin analog at the circulation or target tissue after cleavage of charge-masking lipophilic moieties. Pharmaceutical compositions comprising these prodrugs and their use in therapy and diagnosis are also provided.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: March 1, 2022
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Amnon Hoffman, Chaim Gilon, Adi Klinger, Johnny Naoum
  • LIPOPHILIC PEPTIDE PRODRUGS
    Publication number: 20220016218
    Abstract: The present invention relates to methods of preparing peptide-based prodrugs having enhanced oral bioavailability and intestinal penetration. Said prodrugs are characterized in improved lipophilicity, reduced electric charge and tendency to undergo biotransformation through enzymatic reaction (e.g. in the blood stream) to form biologically active peptides.
    Type: Application
    Filed: July 9, 2021
    Publication date: January 20, 2022
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Amnon HOFFMAN, Chaim GILON, Joseph FANOUS, Adi KLINGER
  • LIPOPHILIC PEPTIDE PRODRUGS
    Publication number: 20200323962
    Abstract: The present invention relates to methods of preparing peptide-based prodrugs having enhanced oral bioavailability and intestinal penetration. Said prodrugs are characterized in improved lipophilicity, reduced electric charge and tendency to undergo biotransformation through enzymatic reaction (e.g. in the blood stream) to form biologically active peptides.
    Type: Application
    Filed: September 17, 2018
    Publication date: October 15, 2020
    Inventors: Amnon HOFFMAN, Chaim GILON, Joseph FANOUS, Adi KLINGER
  • N-METHYLATED CYCLIC PEPTIDES AND THEIR PRODRUGS
    Publication number: 20200283483
    Abstract: The present invention provides N-methylated cyclic hexapeptides comprising RGD and at least one alanine residue. The present invention further provides prodrugs comprising the cyclic hexapeptides. Pharmaceutical compositions comprising said cyclic hexapeptides are also disclosed as well as methods of their production and use in treating integrin related conditions and diseases.
    Type: Application
    Filed: September 17, 2018
    Publication date: September 10, 2020
    Inventors: Horst Otto KESSLER, Chaim GILON, Amnon HOFFMAN, Michael WEINMULLER, Florian RECHENMACHER, Joseph FANOUS, Adi KLINGER
  • SOMATOSTATIN PRODRUGS
    Publication number: 20200262871
    Abstract: The present invention provides prodrugs of somatostatin peptide and peptide analogs that are tissue permeable and oral bioavailable and enable activity of the somatostatin analog at the circulation or target tissue after cleavage of charge-masking lipophilic moieties. Pharmaceutical compositions comprising these prodrugs and their use in therapy and diagnosis are also provided.
    Type: Application
    Filed: September 17, 2018
    Publication date: August 20, 2020
    Inventors: Amnon HOFFMAN, Chaim GILON, Adi KLINGER, Johnny NAOUM