Abstract: Provided herein is a particle made of a protein covalently bound to a prebiotic carbohydrate, thereby forming a conjugate, wherein at least two said conjugates are covalently crosslinked via their carbohydrate units (e.g. by a phospho-di-ester bond). The said particle may be used for selectively promoting probiotic bacteria growth in the colon and may be used to deliver additional probiotic growth factors, or other bioactives and drugs to the colon. Furthermore, provided herein are methods for preparing the particle, and for delivering a substance bound to, or entrapped within the particle, into the gastrointestinal tract of a subject in need thereof.

Abstract: Provided is an edible liquid comprising pomace-derived water soluble polyphenols, alcohol content of less than 3% v/v and potassium content of less than 150 mg/L. The edible liquid is obtained by a method including: mixing pomace with water to obtain an aqueous media including pomace-derived water soluble polyphenols; isolating the aqueous media from particulate matter; and removing potassium from said isolated aqueous media to obtain an edible aqueous liquid. The edible liquid can be process into edible, ready for use products that are rich in beneficiary water soluble, pomace derived polyphenols.

Abstract: Provided herein is a particle made of a protein covalently bound to a prebiotic carbohydrate, thereby forming a conjugate, wherein at least two said conjugates are covalently crosslinked via their carbohydrate units (e.g. by a phospho-di-ester bond). The said particle may be used for selectively promoting probiotic bacteria growth in the colon and may be used to deliver additional probiotic growth factors, or other bioactives and drugs to the colon. Furthermore, provided herein are methods for preparing the particle, and for delivering a substance bound to, or entrapped within the particle, into the gastrointestinal tract of a subject in need thereof.