Patents by Inventor Adil Duran

Adil Duran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of chiral 8-(3-aminopiperidin-1-yl)-xanthines
    Patent number: 9751855
    Abstract: The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: September 5, 2017
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Waldemar Pfrengle, Thorsten Pachur, Thomas Nicola, Adil Duran
  • PROCESS FOR THE PREPARATION OF CHIRAL 8-(3-AMINOPIPERIDIN-1-YL)-XANTHINES
    Publication number: 20170129872
    Abstract: The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines.
    Type: Application
    Filed: January 25, 2017
    Publication date: May 11, 2017
    Inventors: Waldemar PFRENGLE, Thorsten PACHUR, Thomas NICOLA, Adil DURAN
  • PROCESS FOR THE PREPARATION OF CHIRAL 8-(3-AMINOPIPERIDIN-1-YL)-XANTHINES
    Publication number: 20170029402
    Abstract: The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines.
    Type: Application
    Filed: October 11, 2016
    Publication date: February 2, 2017
    Inventors: Waldemar PFRENGLE, Thorsten PACHUR, Thomas NICOLA, Adil DURAN
  • Process for the preparation of chiral 8-(3-aminopiperidin-1-yl)-xanthines
    Patent number: 9499546
    Abstract: The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines.
    Type: Grant
    Filed: October 6, 2014
    Date of Patent: November 22, 2016
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Waldemar Pfrengle, Thorsten Pachur, Thomas Nicola, Adil Duran
  • PROCESS FOR THE PREPARATION OF CHIRAL 8-(3-AMINOPIPERIDIN-1-YL)-XANTHINES
    Publication number: 20150025089
    Abstract: The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 22, 2015
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Waldemar PFRENGLE, Thorsten PACHUR, Thomas NICOLA, Adil DURAN
  • Process for the preparation of chiral 8-(3-aminopiperidin-1-yl)-xanthines
    Patent number: 8883805
    Abstract: The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: November 11, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Waldemar Pfrengle, Thorsten Pachur, Thomas Nicola, Adil Duran
  • Process for the manufacturing of CRR inhibitors
    Patent number: 8680280
    Abstract: The present invention relates to a process for preparing CCR3 inhibitors of formula 1, wherein R1 is H, C1-6-alkyl, C0-4-alkyl-C3-6-cycloalkyl, C1-6-haloalkyl; R2 is H, C1-6-alkyl; X is an anion selected from the group consisting of chloride or ½ dibenzoyltartrate j is 1 or 2.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: March 25, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Adil Duran, Rolf Schmid
  • PROCESS FOR THE MANUFACTURING OF CRR INHIBITORS
    Publication number: 20130261307
    Abstract: The present invention relates to a process for preparing CCR3 inhibitors of formula 1, wherein R1 is H, C1-6-alkyl, C0-4-alkyl-C3-6-cycloalkyl, C1-6-haloalkyl; R2 is H, C1-6-alkyl; X is an anion selected from the group consisting of chloride or ½ dibenzoyltartrate j is 1 or 2.
    Type: Application
    Filed: March 27, 2013
    Publication date: October 3, 2013
    Applicant: Boehringer Ingelehim International GmbH
    Inventors: Adil DURAN, Rolf SCHMID
  • PROCESS FOR THE PREPARATION OF CHIRAL 8-(3-AMINOPIPERIDIN-1-YL)-XANTHINES
    Publication number: 20130178485
    Abstract: The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines.
    Type: Application
    Filed: March 1, 2013
    Publication date: July 11, 2013
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Waldemar PFRENGLE, Thorsten PACHUR, Thomas NICOLA, Adil DURAN
  • Process for the manufacturing of betamimetics
    Patent number: 8420809
    Abstract: The present invention relates to a process for preparing betamimetics of formula 1, wherein n denotes 1 or 2; R1 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R3 denotes hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, O—C1-4-alkylene-COO—C1-4-alkyl.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: April 16, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Thomas Krueger, Uwe Ries, Juergen Schnaubelt, Werner Rall, Zeno A. Leuter, Adil Duran, Rainer Soyka
  • REGIOSELECTIVE PREPARATION OF SUBSTITUTED PYRIMIDINES
    Publication number: 20130079518
    Abstract: The present invention relates to a method of making pyrimidines of formula (III) wherein X1, X2, R1 and R2 have the meanings as defined herein.
    Type: Application
    Filed: November 16, 2012
    Publication date: March 28, 2013
    Inventors: Guenter LINZ, Gerd KRAEMER, Adil DURAN
  • REGIOSELECTIVE PREPARATION OF SUBSTITUTED PYRIMIDINES
    Publication number: 20130079519
    Abstract: The present invention relates to a method of making pyrimidines of formula (III) wherein X1, X2, R1 and R2 have the meanings as defined herein.
    Type: Application
    Filed: November 16, 2012
    Publication date: March 28, 2013
    Inventors: Adil DURAN, Stefan GOEPPER, Joerg HALMER, Michael KONRAD
  • Crystalline, enantiomerically pure salt form of a beta-agonist, and the use thereof as a drug
    Patent number: 8394791
    Abstract: This invention concerns a crystalline, enantiopure hydrochloride salt of N-(5-{2-[3-(4,4-diethyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-1,1-dimethyl-propylamino-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methanesulfonamide, preferably of N-(5-{(R)-2-[3-(4,4-diethyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-1,1-dimethyl-propylamino-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methanesulfonamide and its action as a long acting beta-agonist, alone or in combination with one or multiple other active ingredients for the treatment of respiratory diseases.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: March 12, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Ulrike Werthmann, Marco Santagostino, Adil Duran
  • Regioselective preparation of substituted pyrimidines
    Patent number: 8372974
    Abstract: The present invention relates to a method of making pyrimidines of formula (III), wherein X1, X2, R1 and R2 have the meanings as defined herein.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: February 12, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Guenter Linz, Adil Duran, Gerd Kraemer
  • Regioselective preparation of substituted pyrimidines
    Patent number: 8334383
    Abstract: The present invention relates to a method of making pyrimidines of formula (III), wherein X1, X2, R1 and R2 have the meanings as defined herein.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: December 18, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Adil Duran, Stefan Goepper, Joerg Halmer, Michael Konrad
  • Process for making certain compounds having B1 antagonistic activity
    Patent number: 8207335
    Abstract: The present invention relates to a method of preparing compounds of general formula I wherein m, n, R1 and R2 are defined as mentioned hereinafter, the enantiomers, the diastereomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: June 26, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Adil Duran, Markus Frank, Waldemar Pfrengle, Juergen Schnaubelt
  • CRYSTALLINE, ENANTIOMERICALLY PURE SALT FORM OF A BETA-AGONIST, AND THE USE THEREOF AS A DRUG
    Publication number: 20110262369
    Abstract: The invention relates to a crystalline, enantiomerically pure hydrochloride salt of N-(5-{2-[3-(4,4-diethyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methane sulfonamide, preferably N-(5-{(R)-2-[3-(4,4-diethyl-2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-2-hydroxy-phenyl)-methane sulfonamide, and the effect thereof as a long-term betamimetic agent, alone or combined with at least one other active ingredient, in the treatment of respiratory diseases.
    Type: Application
    Filed: February 17, 2009
    Publication date: October 27, 2011
    Inventors: Ulrike Werthmann, Marco Santagostino, Adil Duran
  • PROCESS FOR THE MANUFACTURING OF BETAMIMETICS
    Publication number: 20110124859
    Abstract: The present invention relates to a process for preparing betamimetics of formula 1, wherein n denotes 1 or 2; R1 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R2 denotes hydrogen, halogen, C1-4-alkyl or O—C1-4-alkyl; R3 denotes hydrogen, C1-4-alkyl, OH, halogen, O—C1-4-alkyl, O—C1-4-alkylene-COOH, O—C1-4-alkylene-COO—C1-4-alkyl.
    Type: Application
    Filed: February 7, 2011
    Publication date: May 26, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Thomas KRUEGER, Uwe RIES, Juergen SCHNAUBELT, Werner RALL, Zeno A. LEUTER, Adil DURAN, Rainer SOYKA
  • REGIOSELECTIVE PREPARATION OF SUBSTITUTED PYRIMIDINES
    Publication number: 20110077403
    Abstract: The present invention relates to a method of making pyrimidines of formula (III), wherein X1, X2, R1 and R2 have the meanings as defined herein.
    Type: Application
    Filed: March 19, 2009
    Publication date: March 31, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Adil Duran, Stefan Goepper, Joerg Halmer, Michael Konrad
  • Process for the manufacture of fused piperazin-2-one derivatives
    Patent number: RE43115
    Abstract: Disclosed are processes for the preparation of fused piperazin-2-one derivatives of general formula (I) wherein the groups R1 to R5, A1 and A2 have the meanings given in the claims and in the description, particularly the preparation of 7,8-dihydro-5H-pteridin-6-one derivatives and intermediates thereof.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: January 17, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Adil Duran, Guenter Linz